In Vivo Performance of a Novel, Anatomically Shaped, Total Meniscal Prosthesis Made of Polycarbonate Urethane: A 12-Month Evaluation in Goats

Vrancken, A.C.T.; Hannink, Gerjon; Madej, Wojciech; Tienen, T.G. van; Buma, P.

doi:10.1177/0363546517713687

Cited by 19 publications

(24 citation statements)

References 44 publications

(67 reference statements)

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“…It should be taken in to account that animal species differ not only in gross joint anatomy but also in details, such as chondrocyte density, cartilage thickness and metabolic differences, which will influence the outcome of the specific OA model 59,60 . Spontaneous OA has been reported for multiple large animal models and should be taken into account 54,61,62 .…”

Section: Discussionmentioning

confidence: 99%

The protective effect of anterior cruciate ligament reconstruction on articular cartilage: a systematic review of animal studies

Deckers

Stephan

Wever

et al. 2019

Osteoarthritis and Cartilage

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s u m m a r yObjective: It is unclear if anterior cruciate ligament (ACL) reconstruction can prevent the onset of degenerative changes in the knee. Previous studies were inconclusive on this subject. The aim of this study was to systematically review all studies on the effect of ACL reconstruction on articular cartilage in animals. Design: Pubmed and Embase were searched to identify all original articles concerning the effect of ACL reconstruction on articular cartilage compared with both its positive (ACL transection) and negative (sham and/or non-operated) control in animals. Subsequently a Risk of bias and meta analysis was conducted based on five outcomes (gross macroscopic assessment, medical imaging, histological histochemical grading, histomophometrics and biomechanical characterization) related to articular cartilage. Results: From the 19 included studies, 29 independent comparisons could be identified which underwent ACL reconstruction with an average timing of data collection of 23 weeks (range 1e104 weeks). Due to limited data availability meta-analysis could only be conducted for gross macroscopic damage. ACL reconstruction caused significant gross macroscopic damage compared with intact controls (SMD 2.0 [0.88; 3.13]). These findings were supported by individual studies reporting on histomorphometrics, histology and imaging. No significant gross macroscopic damage was found when ACL reconstruction was compared with ACL transection (SMD À0.64 [À1.85; 0.57]). Conclusion: This systematic review with an average follow up of included studies of 23 weeks (range 1 e104 weeks) demonstrates that, in animals, ACL reconstruction does not protect articular cartilage from degenerative changes. The consistency of the direction of effect, provides some reassurance that the direction of effect in humans might be the same.

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Section: Discussionmentioning

confidence: 99%

The protective effect of anterior cruciate ligament reconstruction on articular cartilage: a systematic review of animal studies

Deckers

Stephan

Wever

et al. 2019

Osteoarthritis and Cartilage

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“…Non-degradable synthetic solid polyurethane scaffolds were originally designed as total meniscus replacements, however a 2- year follow up study using dogs indicated that the polyurethane implant was not chondroprotective [82] , possibly due to the lack of scaffold degradation at 24 months [92] . Vrancken et al tested a synthetic solid, non-degradable, anatomically shaped polycarbonate urethane scaffold and compared it to the use of MAT in a biomechanical human cadaver model [93] and then a goat animal model [94] . Twelve-month follow-up after total meniscal replacement indicated that while the implant could not prevent the cartilage degeneration, the progression of damage was similar to MAT, in keeping with the results from the ex vivo human cadaver study.…”

Section: Biomaterials For Meniscus Tissue Engineeringmentioning

confidence: 99%

Current Concepts in Meniscus Tissue Engineering and Repair

Bilgen

Jayasuriya

Owens

2018

Adv Healthcare Materials

108

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The meniscus is the most commonly injured structure in the human knee. Meniscus deficiency has been shown to lead to advanced osteoarthritis (OA) due to abnormal mechanical forces, and replacement strategies for this structure have lagged behind other tissue engineering endeavors. The challenges include the complex 3D structure with individualized size parameters, the significant compressive, tensile and shear loads encountered, and the poor blood supply. In this progress report, a review of the current clinical treatments for different types of meniscal injury is provided. The state-of-the-art research in cellular therapies and novel cell sources for these therapies is discussed. The clinically available cell-free biomaterial implants and the current progress on cell-free biomaterial implants are reviewed. Cell-based tissue engineering strategies for the repair and replacement of meniscus are presented, and the current challenges are identified. Tissue-engineered meniscal biocomposite implants may provide an alternative solution for the treatment of meniscal injury to prevent OA in the long run, because of the limitations of the existing therapies.

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“…The application of a prosthetic meniscus device is yet another area of research in the field 101. Implants of this type, however, are highly difficult to design in view of the complicated biomechanical behaviour of the meniscus 13.…”

Section: Specific Populationmentioning

confidence: 99%

Meniscal transplantation: state of the art

et al. 2017

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Meniscal resection is the most common surgical procedure in orthopaedics. When a large meniscal loss becomes clinically relevant, meniscal allograft transplantation (MAT) is a feasible option. However, although this technique has evolved since the ‘80s, there are still several controversial issues related to MAT. Most importantly, its chondroprotective effect is still not completely proven. Its relatively high complication and reoperation rate is another reason for this procedure not yet being universally accepted. Despite its controversial chondroprotective effect, nevertheless, MAT has become a successful treatment for pain localised in a previously meniscectomised knee, in terms of pain relief and knee function. We conducted a careful review of the literature, highlighting the most relevant studies in various aspects of this procedure. Precise indications, how it behaves biomechanically, surgical techniques, return to sport and future perspectives are among the most relevant topics that have been included in this state-of-the-art review.

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In Vivo Performance of a Novel, Anatomically Shaped, Total Meniscal Prosthesis Made of Polycarbonate Urethane: A 12-Month Evaluation in Goats

Abstract: This novel polycarbonate urethane implant may have the potential to become an alternative treatment for symptomatic patients with total meniscectomy.

Cited by 19 publications

References 44 publications

The protective effect of anterior cruciate ligament reconstruction on articular cartilage: a systematic review of animal studies

The protective effect of anterior cruciate ligament reconstruction on articular cartilage: a systematic review of animal studies

Current Concepts in Meniscus Tissue Engineering and Repair

Meniscal transplantation: state of the art

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