In Vivo Performance and Biocompatibility of an Intelligent Artificial Anal Sphincter System

Ding, Han; Yan, Guozheng; Zhao, Kai

doi:10.1145/3383783.3383808

Cited by 1 publication

(1 citation statement)

References 19 publications

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“…Only in vivo animal experimentations are present in the literature, whose surgical outputs seemed to greatly manage the hyperplasia, by replacing nylon‐12 with titanium alloy or polyetheretherketone in the prosthetic device, but the duration is still unsatisfactory for clinical applications (almost 8 months) 86 . The internal artificial anal sphincter (IASS) device proposed by Han et al 87 had the same PAAS technology and design, but the pressure sensors were located in the inner wall of the rings in order to reduce the measurement errors caused by tube deformation, displacement, and abnormal contraction of the intra‐abdominal muscles. Moreover, sleep mode and temperature compensation to reduce burns were added.…”

Section: Novel Devicesmentioning

confidence: 99%

Artificial sphincters: An overview from existing devices to novel technologies

et al. 2022

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Artificial sphincters (ASs) are used to replace the function of the biological sphincters in case of severe urinary and fecal incontinence (UI and FI), and gastroesophageal reflux disease (GERD). The design of ASs is established on different mechanisms, e.g., magnetic forces or hydraulic pressure, with the final goal to achieve a implantable and durable AS. In clinical practice, the implantation of in‐commerce AS is considered a reasonable solution, despite the sub‐optimal clinical outcomes. The failure of these surgeries is due to the malfunction of the devices (between 46 and 51%) or the side effects on the biological tissues (more than 38%), such as infection and atrophy. Concentrating on this latter characteristic, particular attention has been given to the interaction between the biological tissues and AS, pointing out the closing mechanism around the duct and the effect on the tissues. To analyze this aspect, an overview of existing commercial/ready‐on‐market ASs for GERD, UI, and FI, together with the clinical outcomes available from the in‐commerce AS, is given. Moreover, this invited review discusses ongoing developments and future research pathways for creating novel ASs. The application of engineering principles and design concepts to medicine enhances the quality of healthcare and improves patient outcomes. In this context, computational methods represent an innovative solution in the design of ASs, proving data on the occlusive force and pressure necessary to guarantee occlusion and avoid tissue damage, considering the coupling between different device sizes and individual variability.

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Section: Novel Devicesmentioning

confidence: 99%