In vivo optical coherence tomography of basal cell carcinoma

Gambichler, Thilo; Orlikov, Alexej; Vasa, R; Moussa, Georg; Hoffmann, Klaus; Stücker, Markus; Altmeyer, Peter; Bechara, Falk G.

doi:10.1016/j.jdermsci.2006.11.012

Cited by 144 publications

(141 citation statements)

References 15 publications

(24 reference statements)

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“…Previous studies demonstrate OCT images of BCC, SCC, and actinic keratoses (AK) and have correlated these findings with standard histology. [17][18][19][20][21][22][23][24][25] The ability of OCT to differentiate NMSC lesions from normal skin has also been assessed in the clinical setting using observer-blinded evaluation by dermatologists and pathologists. 26 To date, however, most of the clinical investigations in skin disease using OCT have used two-dimensional (2-D) images or relatively low resolution.…”

Section: Introductionmentioning

confidence: 99%

Three-dimensional imaging of normal skin and nonmelanoma skin cancer with cellular resolution using Gabor domain optical coherence microscopy

et al. 2012

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Abstract. We investigate morphological differences in three-dimensional (3-D) images with cellular resolution between nonmelanoma skin cancer and normal skin using Gabor domain optical coherence microscopy. As a result, we show for the first time cellular optical coherence images of 3-D features differentiating cancerous skin from normal skin. In addition, in vivo volumetric images of normal skin from different anatomic locations are shown and compared.

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Section: Introductionmentioning

confidence: 99%

Three-dimensional imaging of normal skin and nonmelanoma skin cancer with cellular resolution using Gabor domain optical coherence microscopy

et al. 2012

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“…must be taken into account [207,211]. Many studies have, however, reported high correlation between OCT images and histology, suggesting that OCT can be used to recognize NMSC lesions [212][213][214].…”

Section: Dermatologymentioning

confidence: 99%

Optical coherence tomography—current technology and applications in clinical and biomedical research

et al. 2011

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Optical coherence tomography (OCT) is a non-invasive imaging technique providing real-time twoand three-dimensional images of scattering samples with micrometer resolution. Mapping the local reflectivity, OCT visualizes the morphology of the sample. In addition, functional properties such as birefringence, motion or the distribution of certain substances can be detected with high spatial resolution. The main field of application is bio-medical imaging and diagnostics. In ophthalmology, OCT is accepted as a clinical standard for diagnosing and monitoring treatment of a number of retinal diseases, and OCT is becoming an important instrument for clinical cardiology. New applications are emerging in various medical fields, e. g. early-stage cancer detection, surgical guidance, and early diagnosis of musculoskeletal diseases. OCT has also proven its value as a tool for developmental biology. The number of companies involved in manufacturing OCT systems has increased substantially during the last years-especially due to its success in opthalmology-and this technology can be expected to continue to spread into various fields of application.

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“…It has also been suggested as an in vivo technique in skin cancer detection [46][47][48][49]. Based on the fact that in basal cell carcinoma the normal appearance of tumorous tissue is altered, polarization-sensitive optical coherence tomography was used to distinguish 2.…”

Section: Optical Coherence Tomographymentioning

confidence: 99%

“…In the studies that have been done using optical coherence tomography, it is expected to detect changes in normal skin architecture and any kind of disorder in the shape of epidermis and upper dermis by means of this technique. For instance Gambichler et al have been able to observe features in the images provided from basal cell carcinoma such as large plug-like signalintense structures, honeycomb-like signal-free structures, and prominent signal free cavities in the upper dermis, which are correlated with histology examination [48]. However, one of the deficiencies in diagnosis based on this technique is a lack of specificity.…”

Section: Optical Coherence Tomographymentioning

confidence: 99%

“…However, one of the deficiencies in diagnosis based on this technique is a lack of specificity. For example, there are statistically insignificant differences between skin cancers of types such as nodular, multifocal superficial, and infiltrative basal cell carcinomas [48]. Despite this, specificity is high in differentiating between normal and cancerous skin tissues [49].…”

Section: Optical Coherence Tomographymentioning

confidence: 99%

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Skin cancer detection using laser imaging

Mowla¹

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Endeavors to develop a non-invasive and reliable device to detect different types of skin cancer in its early stages have been undertaken over the past few years. Although some advances have been made towards such developments, there remains great scope for the development of a non-expensive, compact, reliable, safe, easy to use, fast, sensitive, and non-invasive device. This project will apply the innovative laser feedback interferometry (LFI) technique to skin cancer detection via laser imaging using near-infrared vertical cavity surface emitting lasers (VCSELs). In this project, the science behind lighttissue interactions has been explored and skin imaging modalities have been elaborately studied. As a result, LFI has been exploited in various configurations to image different modalities such as Doppler flowmetry and confocal reflectance. In addition to single modality imaging, dual-modality imaging has also been proposed and conducted experimentally, to image Doppler flowmetry and confocal reflectance at the same time, using an integrated LFI system. It is shown that dual-modality imaging can yield images with higher contrast which provide more information about morphological and functional characteristics of a target under test.In addition to two-dimensional LFI imaging, three-dimensional imaging systems have also been studied and employed in the laboratory. A tomographic image identifies tissue volume with altered optical properties due to cancerous or other malignant tissue processes. We applied the three-dimensional imaging system to different types of keratinocyte skin cancer phantoms and results show high level of sensitivity in providing tomographic images. Using high numerical aperture lenses, making images at resolutions down to micrometer scales is possible, which is promising for microscopy of biological structures.Furthermore, parallel LFI imaging using an array of 24 VCSELs was also studied theoretically and experimentally as a part of this work. A VCSEL array was used in a parallel read-out LFI imaging system to develop a fast and high resolution device, which eliminates the need to scan mechanically in one dimension.Investigating the complex interactions of the laser beam and tissue requires a powerful and robust simulation technique. Monte Carlo was used as a simulation technique to model the light-tissue interactions occurring in the optical systems in this work. Firstly, we tested and validated the Monte Carlo main engine which was developed in the group, by studying morphological aspects of the simulated and experimental signals in a laser Doppler velocimetry system, and deep insight into the nature of the LFI Doppler spectrum and further conclusions were drawn. Secondly, the Monte Carlo engine was used in iii modeling and analyzing of optical systems, in this work.We developed tissue phantom making techniques which were used to examine the experimental ideas in place of biological samples which are difficult to obtain and work with. Therefore, tissue phantom techniques were studie...

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In vivo optical coherence tomography of basal cell carcinoma

Cited by 144 publications

References 15 publications

Three-dimensional imaging of normal skin and nonmelanoma skin cancer with cellular resolution using Gabor domain optical coherence microscopy

Three-dimensional imaging of normal skin and nonmelanoma skin cancer with cellular resolution using Gabor domain optical coherence microscopy

Optical coherence tomography—current technology and applications in clinical and biomedical research

Skin cancer detection using laser imaging

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