In vivo ocular biomechanical compliance in thyroid eye disease

Vellara, Hans; Hart, Richard T.; Gokul, Akilesh; McGhee, Charles N J; Patel, Dipika V.

doi:10.1136/bjophthalmol-2016-309532

Cited by 16 publications

(12 citation statements)

References 11 publications

(17 reference statements)

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“…Thus, hypothesizing the relationship between the ORA-measured CH value and the progression of glaucomatous VF damage relies on the WEM, because the accuracy of the measurement of CH value depends on WEM, the main purpose of this study was to investigate the influence of these WEM parameters on the relationship between CH and glaucomatous VF progression. Further, since mechanical conditions in orbit is known to affect WEM 9 , we also investigated the effect of topical usage of PGA prescribed for glaucoma patients on WEM along with other parameters because PGA induces histological and mechanical changes in not only orbital tissue but also eyelids 10 – 12 , cornea and sclera 13 – 15 .…”

Section: Introductionmentioning

confidence: 99%

The effect of air pulse-driven whole eye motion on the association between corneal hysteresis and glaucomatous visual field progression

Aoki

Murata

Fujino

et al. 2018

Sci Rep

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Corneal hysteresis (CH) measured with Ocular Response Analyzer (Reichert: ORA) has been reported to be closely related to the glaucomatous visual field (VF) progression. The air pulse applied to an eye not only induces corneal deformation, but also whole eye motion (WEM), which may result in an inaccurate measurement of CH. Here we investigated the influence of air pulse-driven WEM measured with the Corivs ST (CST®, OCULUS) on the relationship between CH and VF progression in primary open angle-glaucoma patients. Using the CST parameters of the maximal WEM displacement (WEM-d) and the time to reach that displacement (WEM-t), the eyes were classified into subgroups (WEM-d low- and high-group, and WEM-t short- and long-group). For the whole population and all subgroups, the optimal linear mixed model to describe mean of total deviation (mTD) progression rate with eight reliable VFs was selected from all combinations of seven parameters including CH. As a result, optimal models for the mTD progression rate included CH in the whole population, the WEM-d low- group and the WEM-t short-group, but not in the WEM-d high-group and the WEM-t long-group. Our findings indicated association between CH and glaucomatous progression can be weakened because of large WEM.

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Section: Introductionmentioning

confidence: 99%

The effect of air pulse-driven whole eye motion on the association between corneal hysteresis and glaucomatous visual field progression

Aoki

Murata

Fujino

et al. 2018

Sci Rep

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“…Multiple studies show clinically relevant applications for the Corvis‐ST . Ectatic corneas have been primarily investigated, and associated with higher DAs and lower A1 stiffness parameters than normal corneas .…”

Section: Discussionmentioning

confidence: 99%

“…Multiple studies show clinically relevant applications for the Corvis-ST. [1][2][3][4]11 Ectatic corneas have been primarily investigated, and associated with higher DAs and lower A1 stiffness parameters than normal corneas. 11,27 A corneal biomechanical index (CBI) for the diagnosis of corneal ectatic disease with the Corvis ST has also been created, which incorporates data from both the DA ratios and the A1 stiffness parameter along with the A1 velocity, the SD of DA at HC and Ambrósio's relational thickness to the horizontal profile.…”

Section: Discussionmentioning

confidence: 99%

“…Corneal biomechanics is the study of corneal deformation in response to external forces. Recent research has demonstrated that the measurement of corneal biomechanical parameters in vivo has clinical applications, including detecting and monitoring patients with glaucoma or keratoconus, assessing blood sugar control in diabetes and evaluating the severity of thyroid eye disease …”

Section: Introductionmentioning

confidence: 99%

“…Recent research has demonstrated that the measurement of corneal biomechanical parameters in vivo has clinical applications, including detecting and monitoring patients with glaucoma or keratoconus, 1,2 assessing blood sugar control in diabetes 3 and evaluating the severity of thyroid eye disease. 4 The Corneal Visualisation Scheimpflug Technology (Corvis-ST; Oculus, Wetzlar, Germany) is a recently developed non-contact tonometry system. 5 The Corvis-ST uses a 60 mmHg, 3.05 mm diameter collimated air pulse to deform the cornea while dynamically capturing the resulting corneal curvature changes in space and time using a high-speed Scheimpflug camera at a rate of 4300 frames per second.…”

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confidence: 99%

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Biomechanical changes in the cornea following cataract surgery: A prospective assessment with the Corneal Visualisation Scheimpflug Technology

Wallace

Misra

et al. 2019

Clinical Exper Ophthalmology

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Importance Intraocular pressure (IOP) is often reduced following cataract surgery. Postoperative changes in corneal stiffness are likely to be at least partly responsible for any reduction in IOP measured with applanation tonometry. Background To determine the effect of cataract surgery and corneal incision size on corneal biomechanics. Design Prospective randomized trial. Participants One hundred prospectively enrolled patients qualifying for cataract surgery. Methods Participants were randomized to clear corneal incisions with a 2.20 or 2.85 mm keratome. Corneal Visualisation Scheimpflug Technology (Corvis‐ST) tonometry and dynamic corneal response measurements were obtained preoperatively, and 3 mo postoperatively. Multiple regression analysis was completed using R software. Main Outcome Measures Corvis‐ST biomechanical parameters. Results Ninety‐three eyes of 93 patients were included in the final analysis. Mean Corvis‐ST biomechanically corrected IOP decreased by 3.63 mmHg postoperatively (95% confidence interval = 2.97‐4.35, P ≤ 0.01), and central pachymetry increased by 6.96 μm (4.33‐9.59, P ≤ 0.01). Independent of IOP and pachymetry changes, mean (±SE) corneal first applanation stiffness parameter reduced by 9.761 ± 3.729 (P = 0.01) postoperatively. First applanation velocity increased by 0.007 ± 0.002 ms, second applanation velocity increased by 0.012 ± 0.004 ms (P ≤ 0.01), the first applanation deformation amplitude increased by 0.008 ± 0.002 mm (P ≤ 0.01) and the deflection amplitude at highest concavity increased by 0.030 ± 0.069 (P ≤ 0.01). There were no significant differences between different incision size groups. Conclusions and Relevance Corneal stiffness is reduced 3 mo following cataract surgery and is associated with falsely low IOP measurements. This finding may be important for glaucoma patients and in particular when assessing the effectivity of minimally invasive glaucoma surgery devices.

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Dynamischer Scheimpflug-Analyzer (Corvis ST) zur Bestimmung kornealer biomechanischer Parameter

et al. 2018

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In vivo ocular biomechanical compliance in thyroid eye disease

Abstract: The in vivo ocular biomechanics as measured by the CST reflects a reduced orbital compliance. This method of ocular biomechanical assessment may aid in the categorisation of TED severity and assist in monitoring and/or diagnosing TED.

Cited by 16 publications

References 11 publications

The effect of air pulse-driven whole eye motion on the association between corneal hysteresis and glaucomatous visual field progression

The effect of air pulse-driven whole eye motion on the association between corneal hysteresis and glaucomatous visual field progression

Biomechanical changes in the cornea following cataract surgery: A prospective assessment with the Corneal Visualisation Scheimpflug Technology

Dynamischer Scheimpflug-Analyzer (Corvis ST) zur Bestimmung kornealer biomechanischer Parameter

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