In vivo observations and in vitro experiments on the oral phase of swallowing of Newtonian and shear-thinning liquids

Mowlavi, Saviz; Engmann, Jan; Burbidge, Adam; Lloyd, Robert; Hayoun, Pascaline; Révérend, Benjamin Le; Ramaioli, Marco

doi:10.1016/j.jbiomech.2016.10.011

Cited by 36 publications

(62 citation statements)

References 19 publications

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“…The geometrical, kinematic 160 and dynamic agreement of the bolus flow can be qualitatively appreciated in Figure 2. A more detailed comparison will be the object of another publication (Mowlavi et al, 2015) .…”

Section: Theorymentioning

confidence: 99%

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A model experiment to understand the oral phase of swallowing of Newtonian liquids

Hayoun

Engmann

Mowlavi

et al. 2015

Journal of Biomechanics

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Section: Theorymentioning

confidence: 99%

“…Given the fast dynamics, this study assumes that no active control takes place during 295 swallowing and that the process takes place under the action of an imposed force. A more detailed comparison of the dynamics of model experiments and in vivo flow will be the focus of another publication (Mowlavi et al, 2015).…”

mentioning

confidence: 99%

A model experiment to understand the oral phase of swallowing of Newtonian liquids

Hayoun

Engmann

Mowlavi

et al. 2015

Journal of Biomechanics

Self Cite

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“…In particular, the inertial regime, below t = 0.1s, is still well predicted by the theory and the theoretical curves are close to the initial slope of the experimental data. Experiments at reduced external forces (2 N) have been previously demonstrated to best match in vivo ultrasound observations [8] and are therefore the conditions closest to a human swallow. The in vitro results show that angular velocity decreases, when increasing the size of the spherical inclusion.…”

Section: Resultsmentioning

confidence: 83%

“…Building on the results obtained in previous studies [7] and [8], this article proposes a novel approach to study the swallowing dynamics of hard particles in liquids with high viscosity during the oropharyngeal phase of human swallowing. Spherical and non-spherical inclusions in size ranging 4.8 to 10 mm were considered.…”

Section: Discussionmentioning

confidence: 99%

A model experiment to study swallowing of spherical and elongated particles

et al. 2017

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Abstract. Swallowing disorders are not uncommon among elderly and people affected by neurological diseases. For these patients the ingestion of solid grains, such as pharmaceutical oral solid formulations, could result in choking. This generally results in a low compliance in taking solid medications. The effect of the solid medication size on the real or perceived ease of swallowing is still to be understood from the mechanistic viewpoint. The interplay of the inclusion shape and the rheology of the liquid being swallowed together with the medication is also not fully understood. In this study, a model experiment was developed to study the oropharyngeal phase of swallowing, replicating the dynamics of the bolus flow induced by the tongue (by means of a roller driven by an applied force). Experiments were performed using a wide set of solid inclusions, dispersed in a thick Newtonian liquid. Predictions for a simple theory are compared with experiments. Results show that an increase in the grain size results in a slower dynamics of the swallowing. Furthermore, the experiments demonstrated the paramount role of shape, as flatter and more streamlined inclusions flow faster than spherical. This approach can support the design of new oral solid formulations that can be ingested more easily and effectively also by people with mild swallowing disorders.

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“…That solution well-matched the experimental results in the case of pure Newtonian liquids. Later, Mowlavi et al extended the investigation to shear thinning liquids [13]. In their model, the drag force can be described by the mathematical expression presented in Eq.…”

Section: Theorymentioning

confidence: 99%

Transient peristaltic transport of grains in a liquid

et al. 2017

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Abstract. Pumping suspensions and pastes has always been a significant technological challenge in a number of industrial applications ranging from food processing to mining. Peristaltic pumps have become popular to pump and/or dose complex fluids, due to their robustness. During the transport of suspensions with peristaltic pumps, clogging issues may arise, particularly during transient operations. That is a matter of particular concern whenever the pumping device is used intermittently to generate flow only on demand. Further understanding of the transient dynamics of such systems and of the conditions that can lead to jamming would result in more robust peristaltic pump design. To achieve these goals, an experimental setup that simplifies the statorrotor assembly of a peristaltic hose pump was used. In this setup, a roller transfers momentum to a liquid suspension, upon application of a constant load. The evolution of the velocity of the roller was recorded for different concentrations of mono-dispersed spheres of different diameters. The flow is found not to be strongly dependent on the dispersed particle volume fraction, if the size of the suspended phase is comparable with the hose diameter. Conversely, the flow is strongly slowed down when their size is small and the particle concentration is increased. These findings could help improving the design of peristaltic pumps by a more appropriate sizing, given the diameter of the hose and that of the particles to be transported.

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In vivo observations and in vitro experiments on the oral phase of swallowing of Newtonian and shear-thinning liquids

Cited by 36 publications

References 19 publications

A model experiment to understand the oral phase of swallowing of Newtonian liquids

A model experiment to understand the oral phase of swallowing of Newtonian liquids

A model experiment to study swallowing of spherical and elongated particles

Transient peristaltic transport of grains in a liquid

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