In vivo normobaric hyperoxia preconditioning induces different degrees of antioxidant enzymes activities in rat brain tissue

Bigdeli, Mohammad Reza; Rasoulian, Bahram; Meratan, Ali Akbar

doi:10.1016/j.ejphar.2009.03.034

Cited by 32 publications

(31 citation statements)

References 38 publications

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“…Third, normobaric hyperoxia can increase antioxidant enzyme activities (superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase). 34 Finally, antioxidant treatment has been proven to protect the spinal GABA neurons from impairment of oxidative stress and subsequently inhibit the development of neuropathic pain. 35 There are also some limitations to our study.…”

Section: Discussionmentioning

confidence: 99%

“…Most studies on oxygen therapy in treatment with pain ranged from 15 to 70 min, [14][15][16] and most studies of InHO in neuroscience designated 4 h per day for six consecutive days (almost a week) as their treatment. 21,22,34 We regarded daily term (1 h per day, 2 h per day and 4 h per day) and weeks (1 week, 2 weeks and 4 weeks) of InHO therapy as factors. This meant that 10 groups of patients were required for our trial.…”

Section: Discussionmentioning

confidence: 99%

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Effect of intermittent normobaric hyperoxia for treatment of neuropathic pain in Chinese patients with spinal cord injury

Gui

Zhao

et al. 2014

Spinal Cord

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Study design: Prospective, randomized and controlled study. Objectives: The aim of the study was to investigate the effect of intermittent normobaric hyperoxia (InHO) for treatment of neuropathic pain in patients with spinal cord injury (SCI). Setting: The First Affiliated Hospital of Nanhua University, Hengyang, Hunan Province, China. Methods: Patients with SCI from Hunan Province were recruited from the First Affiliated Hospital of Nanhua University. History, duration, localization and characteristics of pain were recorded. Visual analog scale (VAS), the Patient Global Impression of Change (PGIC) and Short Form-36 walk-wheel (SF-36ww) was used to investigate the effect of InHO. Patients were randomly assigned to study and control groups. In study group, patients were exposed to pure oxygen via non-rebreathing reservoir mask, which increased the provided oxygen at a rate of 7 l min − 1 for 1 or 4 h daily in 2 weeks. While in control group, patients breathed air via non-rebreathing reservoir mask at the same rate. Results: A total of 62 SCI patients with neuropathic pain were included in the study. The mean age of the patients was 36.85 ± 10.71 years. Out of 62 patients, 21 were tetraplegic and 41 were paraplegic. Overall, 14 patients had complete SCI while 48 patients had incomplete injuries. Three groups were similar with respect to age, gender, duration, smoker or not, level and severity of injury. In the 4 h per day InHO groups, a statistically significant reduction of the VAS values was observed (Po0.05). Significant difference was also found in SF-36ww pain scores and PGIC (Po0.05). However, such an effect was not evident in the control group. In one-third of those, the pain is severe. 3 Chronic neuropathic pain is often associated with conditions such as depression and anxiety, and strongly affects daily functioning and overall quality of life. 4,5 Many people with SCI rate chronic neuropathic pain as one of the most difficult problems to manage. Pharmacotherapy includes anticonvulsants, antidepressants, opioids and local anesthetics, 6,7 but responses vary and side effects limit compliance. Non-pharmacological treatments such as physical therapy, relaxation, hyperbaric oxygen and acupuncture are suggested. [8][9][10][11][12][13] Oxygen therapy has been clinically used for the treatment of chronic obstructive pulmonary disease and severe oxygen desaturation. Recent researches have reported that oxygen therapy appears to be effective in the pain management and show same effectiveness as hyperbaric oxygen. [14][15][16] Though studies have revealed the analgesic effect of hyperbaric oxygen in both rats and human with neuropathic pain, 13,17-19 costs and poor availability limit the use of hyperbaric oxygen. These prompt us to investigate the effect of intermittent normobaric hyperoxia (InHO) in the treatment of neuropathic pain.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of intermittent normobaric hyperoxia for treatment of neuropathic pain in Chinese patients with spinal cord injury

Gui

Zhao

et al. 2014

Spinal Cord

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“…14 Some studies suggest that intermittent and prolonged normobaric hyperoxia induces brain ischemic tolerance. 15,16 Bigdeli et al showed the intermittent and prolonged normobaric hyperoxia resulted in increase antioxidant enzymes activities. 15 It is known that normobaric hyperoxia can lead to enhanced ROS generation.…”

mentioning

confidence: 99%

“…15,16 Bigdeli et al showed the intermittent and prolonged normobaric hyperoxia resulted in increase antioxidant enzymes activities. 15 It is known that normobaric hyperoxia can lead to enhanced ROS generation. ROS may stimulate the activation of antioxidant enzymes including superoxide dismutase, glutathione peroxidase, catalase, and glutathione reductase, which play an important role in the brain ischemic tolerance.…”

mentioning

confidence: 99%

“…ROS may stimulate the activation of antioxidant enzymes including superoxide dismutase, glutathione peroxidase, catalase, and glutathione reductase, which play an important role in the brain ischemic tolerance. 15 Although ROS production has several theoretical adverse effects, HBO has been successfully used in experimental models of ischemic reperfusion injury including myocardium, skeletal muscle, small intestine, and the liver. 17 Lipid peroxidation occurs in the presence of ischemic reperfusion injury due to the release of ROS.…”

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confidence: 99%

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Normobaric hyperoxia preconditioning ameliorates cisplatin nephrotoxicity

Saadat¹,

Maghani²,

Rahimi³

et al. 2013

Renal Failure

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Background: Cisplatin is a potent anticancer drug, but its nephrotoxicity limits the clinical use of it. To reduce the Cisplatin-induced nephrotoxicity, various interventions have been implicated. The aim of this study was to examine whether preconditioning with normobaric hyperoxia would prevent Cisplatin-induced nephrotoxicity in patient with solid tumor. Methods: In a prospective study, 80 adult patients with solid tumor who were treated with Cisplatin between February 2011 and December 2011 were included. Forty-three patients were exposed to pure oxygen via non-rebreathing reservoir mask which increased the provided oxygen rate to 60% oxygen for 2 hours at 48, 24, and 6 hours before intravenous administration of Cisplatin and 37 patients received only Cisplatin as a control group. Estimated glomerular filtration rate (eGFR) calculated in all patients on day 1 before and on days 1, 3, 6, 30 after Cisplatin exposures. Results: Patients treated with Cisplatin and 60% oxygen showed a mild improvement in eGFR and mild reduction of serum creatinine after 30 days with statistically mild significant differences (p ¼ 0.048). Conclusion: This study showed that normobaric and intermittent precondition of 60% oxygen prior to Cisplatin treatment had an acute transient adverse effect on renal function; however, the improvement of renal function will be seen after 30 days. Thus, it may help to prevent Cisplatin nephrotoxicity.

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Preconditioning for SAH

Ostrowski

Zhang

2012

Innate Tolerance in the CNS

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In vivo normobaric hyperoxia preconditioning induces different degrees of antioxidant enzymes activities in rat brain tissue

Cited by 32 publications

References 38 publications

Effect of intermittent normobaric hyperoxia for treatment of neuropathic pain in Chinese patients with spinal cord injury

Effect of intermittent normobaric hyperoxia for treatment of neuropathic pain in Chinese patients with spinal cord injury

Normobaric hyperoxia preconditioning ameliorates cisplatin nephrotoxicity

Preconditioning for SAH

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