In vivo normative atlas of the hippocampal subfields using multi‐echo susceptibility imaging at 7 Tesla

Abstract

We constructed a high-resolution atlas of the hippocampal subfields for use in voxel-based studies and demonstrated in vivo quantification of susceptibility and R2* in the subfields. This work is the first in vivo quantification of susceptibility values within the hippocampal subfields at 7 T.

The spectrum of structural and functional imaging abnormalities in temporal lobe epilepsy

“…6,[34][35][36] To increase spatial resolution and diagnostic sensitivity, a few studies have subdivided the hippocampus 29 or targeted its substructure using high-fields systems at 3T and beyond. [37][38][39] These assessments did reveal anomalies not otherwise detected on conventional imaging. Although the current work similarly took advantage of submillimetric data acquisition and hippocampal subfield segmentations, 19 our approach was further extended by feeding data into a surface postprocessing that minimized partial volume effects during multiparameter sampling, while ensuring shape-intrinsic across-subject correspondence along the anatomical continuum of individual subregions.…”

Relevance of hippocampal integrity for memory outcome after surgical treatment of mesial temporal lobe epilepsy

“…Since hippocampal cell counts cannot be determined before epilepsy surgery, presurgical biomarkers of the structural and functional integrity of the hippocampus would be appreciated that would advance individual risk-benefit evaluations before elective epilepsy surgery (e.g. high-field MRI [44,45], volumetric and FLAIR analysis [46], spectroscopy [47], relaxometry [48], diffusion tensor imaging [49], memory fMRI [50], and EEGanalyses [51,52]). …”

Cortical microarchitecture changes in genetic epilepsy

“…39,40 The neuronal network changes described here would be expected to lead to alterations in connectivity in patients and are amenable to quantification using these new approaches. 39,40 The neuronal network changes described here would be expected to lead to alterations in connectivity in patients and are amenable to quantification using these new approaches.…”