In vivo NMR of drugs

Komoroski, Richard A.

doi:10.1021/ac00092a002

Cited by 17 publications

(7 citation statements)

References 33 publications

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“…The magnitude of the pharmacologic effect of a drug depends on the concentration at the receptor sites in the target tissue, which may not be reflected in the serum concentration. Thus, the concentration of Li in the brain may be a better measure of Li therapy or toxic effects (2,3). There is a need for a noninvasive, in vivo measure of Li concentration, particularly one that can be applied to humans.…”

Section: Introductionmentioning

confidence: 99%

Lithium Visibility in Rat Brain and Musclein Vivoby7Li NMR Imaging

Komoroski

Pearce

Newton

1998

Journal of Magnetic Resonance

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Section: Introductionmentioning

confidence: 99%

Lithium Visibility in Rat Brain and Musclein Vivoby7Li NMR Imaging

Komoroski

Pearce

Newton

1998

Journal of Magnetic Resonance

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“…The magnitude of the pharmacologic effect of a drug depends on the concentration at the receptor sites in the target tissue, which may not be reflected in the serum concentration. Thus the concentration of Li in the brain may be a better measure of Li therapy (3,4). In addition, regional variations in Li concentration may occur in brain and may be important with regard to the mechanism of action.…”

Section: Introductionmentioning

confidence: 99%

The distribution of lithium in rat brain and muscle in vivo by ⁷Li NMR imaging

Komoroski

Pearce

Newton

1997

Magnetic Resonance in Med

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The regional distribution of lithium (Li) in vivo was determined on a relative basis in the brain and muscle of rats by 7Li NMR imaging. Both high resolution 7Li NMR spectroscopy and atomic absorption spectrophotometry were performed on extracts of brain and muscle tissue from the same rats. The average in vivo results were generally in good agreement with the corresponding average in vitro results, despite the relatively low signal-to-noise ratio of the in vivo images. There was good agreement between the two in vitro methods of analysis, both on average and for individual animals. Significant differences were found in vivo among Li concentration ratios for the various brain regions and muscle by 7Li imaging, as well as by the in vitro methods.

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“…Furthermore investigations for a new screening method of boron determination by NMR with high strength magnetic Strahlenther Onkol 1999;175:Supp111:118-20 field are in progress [14,20]. This would allow a more rapid analysis of drug biodistribution in living, anesthesized animals.…”

Section: Discussionmentioning

confidence: 99%

New drugs for BNCT: An experimental approach

Weissfloch

Bremer

Lemmen³

et al. 1999

Strahlenther Onkol

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New kinds of boron-containing drugs were developed and tested in several murine tumor models. The boron-containing ether lipid B-Et-11-OMe was injected in mammary carcinoma (AT17) and osteosarcoma (OTS-64) bearing mice. Furthermore boron-substituted ferrocenium derivatives were tested. Two were excessively toxic; the third could be investigated. Boron accumulation and time-dependent biodistribution were determined using alpha-particle sensitive films and inductively coupled plasma-atomic emission pectrometry (ICP-AES) and -mass spectrometry (ICP-MS) of tumors, organs and tissues. Additionally, a new method of boron detection by NMR is in preparation.

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In vivo NMR of drugs

Cited by 17 publications

References 33 publications

Lithium Visibility in Rat Brain and Musclein Vivoby7Li NMR Imaging

Lithium Visibility in Rat Brain and Musclein Vivoby7Li NMR Imaging

The distribution of lithium in rat brain and muscle in vivo by ⁷Li NMR imaging

New drugs for BNCT: An experimental approach

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In vivo NMR of drugs

Cited by 17 publications

References 33 publications

Lithium Visibility in Rat Brain and Musclein Vivoby7Li NMR Imaging

Lithium Visibility in Rat Brain and Musclein Vivoby7Li NMR Imaging

The distribution of lithium in rat brain and muscle in vivo by 7Li NMR imaging

New drugs for BNCT: An experimental approach

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The distribution of lithium in rat brain and muscle in vivo by ⁷Li NMR imaging