In Vivo Neutrophil Dysfunction in Cirrhotic Patients with Advanced Liver Disease

Fiuza, Carmen; Salcedo, Magdalena; Clemente, G.; Tellado, Jose M.

doi:10.1086/315742

Cited by 176 publications

(144 citation statements)

References 47 publications

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“…Furthermore in two of these four patients complications related to liver cirrhosis as hepatocellular carcinoma, portosystemic encephalopathy and spontaneous bacterial peritonitis, were present. Patients with decompensated liver cirrhosis have an increased susceptibility to develop opportunistic infections as rhinocerebral mucormycosis for an alteration of neutrophils chemotaxis and phagocytosis [8,9]. Neutrophil metabolic activity diminishes together with the intensification of liver failure and the metabolic potential of phagocytizing neutrophils is significantly lower in liver cirrhosis patients.…”

Section: Discussionmentioning

confidence: 99%

Liver cirrhosis and rhino-orbital mucormycosis, a possible but rare association: description of a clinical case and literature review

Pellicelli

D’Ambrosio²,

Villani³

et al. 2009

Braz J Infect Dis

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Section: Discussionmentioning

confidence: 99%

Liver cirrhosis and rhino-orbital mucormycosis, a possible but rare association: description of a clinical case and literature review

Pellicelli

D’Ambrosio²,

Villani³

et al. 2009

Braz J Infect Dis

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“…22,23 Several other abnormalities of the immune system cells have been described, including impaired phagocytosis, myeloperoxidase production and chemotaxis of neutrophils to the infection site; dysfunction and reduction of B cell lymphocytes; presence of T cell lymphopenia with impairment of cell mediated immunity. 11,21,[24][25][26] In patients with LC dysregulated bacterial translocation is facilitated by three factors: i) bacteria overgrowth, ii) the impairment of intestinal barrier function and iii) the dysfunction of local immune defenses.…”

Section: Pathophysiology Of Bsis In Patients With Liver Cirrhosis: Inmentioning

confidence: 99%

Bloodstream infections in patients with liver cirrhosis

et al. 2016

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Bloodstream infections are a serious complication in patients with liver cirrhosis. Dysregulated intestinal bacterial translocation is the predominant pathophysiological mechanism of infections in this setting. For this reason enteric Gram-negative bacteria are commonly encountered as the first etiological cause of infection. However, through the years, the improvement in the management of cirrhosis, the recourse to invasive procedures and the global spread of multidrug resistant pathogens have importantly changed the current epidemiology. Bloodstream infections in cirrhotic patients are characterized by high mortality rate and complications including metastatic infections, infective endocarditis, and endotipsitis (or transjugular intrahepatic portosystemic shunt-related infection). For this reason early identification of patients at risk for mortality and appropriated therapeutic management is mandatory. Liver cirrhosis can significantly change the pharmacokinetic behavior of antimicrobials. In fact hypoproteinaemia, ascitis and third space expansion and impairment of renal function can be translated in an unpredictable drug exposure.

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“…Delineating the molecular mechanisms that coordinate this process is crucial for understanding the normal response to tissue damage. Furthermore, abnormalities in this early response have been linked to the pathogenesis of several diseases [3][4][5][6], and its modulation by pharmacological agents has important therapeutic implications.…”

Section: Introductionmentioning

confidence: 99%

Modified skin window technique for the extended characterisation of acute inflammation in humans

et al. 2007

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Objective-To modify the skin window technique for extended analysis of acute inflammatory responses in humans, and demonstrate its applicability for investigating disease.Subjects-15 healthy subjects and 5 Crohn's patients.Treatment-Skin windows, created by dermal abrasion, were overlaid for various durations with filter papers saturated in saline, 100 ng/ml muramyl dipeptide (MDP) or 10 μg/ml interleukin-8 (IL-8).Methods-Exuded leukocytes were analyzed by microscopy, immunoblot, DNA-bound transcription factor arrays and RT-PCR. Inflammatory mediators were quantified by ELISA.Results-Infiltrating leukocytes were predominantly neutrophils. Numerous secreted mediators were detectable. MDP and IL-8 enhanced responses. Many signalling proteins were phosphorylated with differential patterns in Crohn's patients, notably PKC α/β hyperphosphorylation (11.3 ± 3.1 vs 1.2 ± 0.9 units, P < 0.02). Activities of 44 transcription factors were detectable, and sufficient RNA isolated for expression analysis of over 400 genes.Conclusions-The modifications enable broad characterisation of inflammatory responses and administration of exogenous immunomodulators.

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In Vivo Neutrophil Dysfunction in Cirrhotic Patients with Advanced Liver Disease

Cited by 176 publications

References 47 publications

Liver cirrhosis and rhino-orbital mucormycosis, a possible but rare association: description of a clinical case and literature review

Liver cirrhosis and rhino-orbital mucormycosis, a possible but rare association: description of a clinical case and literature review

Bloodstream infections in patients with liver cirrhosis

Modified skin window technique for the extended characterisation of acute inflammation in humans

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