Abstract:The temporal and concentration response of microdialysis probes in vivo was characterized. The temporal response was monitored using step changes in dopamine (DA) concentration which were followed with one minute sampling using smallbore HPLC. The response under three conditions was examined: in vitro sampling of DA, in vitro infusion of DA, and local infusion of DA. The dialysate DA concentration stabilized within two minutes after each change. These results suggest that relatively fast changes in DA levels i… Show more
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