In vivo Messung der D2 Rezeptorblockade im Striatum durch verschiedene Neuroleptika und Kalziumantagonisten mit [123J]-Jodobenzamid und der SPECT Technik

Brücke, Thomas; Wöber, Ch.; Strobl, Ralf; Wenger, S.; Asenbaum, S.; Wöber‐Bingöl, Çiçek; Podreka, I.

doi:10.1007/978-3-7091-9263-4_116

Biologische Psychiatrie Der Gegenwart 1993

DOI: 10.1007/978-3-7091-9263-4_116

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In vivo Messung der D2 Rezeptorblockade im Striatum durch verschiedene Neuroleptika und Kalziumantagonisten mit [123J]-Jodobenzamid und der SPECT Technik

Thomas Brücke

Ch. Wöber

Ralf Strobl

et al.

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1995

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D2-receptor imaging with [123I]IBZM and Single Photon Emission Tomography in psychiatry: a survey of current status

Schlößer

Schlegel

1995

J. Neural Transmission

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D2-dopamine receptors can be visualized in the human brain in vivo by Single Photon Emission Tomography (SPECT) and the radiolabeled benzamide [123I]IBZM. The present paper reviews the current status of this type of functional brain imaging with respect to basic methodological aspects, data analysis and quantification. The results from published clinical studies in different psychiatric patient populations and normal controls with [123I]IBZM are reviewed. [123I]IBZM-SPECT is a powerful tool for the investigation of D2-dopamine receptor status in psychiatric disorders, different types of drug treatment as well as therapeutic and side effects of pharmacologic agents. However, there still is a need for standardized imaging times and image-processing procedures. Advantages and disadvantages of SPECT with special regard to Positron Emission Tomography (PET) are also discussed.

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D2-receptor imaging with [123I]IBZM and Single Photon Emission Tomography in psychiatry: a survey of current status

Schlößer

Schlegel

1995

J. Neural Transmission

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In vivo Messung der D2 Rezeptorblockade im Striatum durch verschiedene Neuroleptika und Kalziumantagonisten mit [123J]-Jodobenzamid und der SPECT Technik

Cited by 1 publication

References 12 publications

D2-receptor imaging with [123I]IBZM and Single Photon Emission Tomography in psychiatry: a survey of current status

D2-receptor imaging with [123I]IBZM and Single Photon Emission Tomography in psychiatry: a survey of current status

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