In Vivo Measurements of Vascular Oxygen Tension in Tumors Using MRI of a Fluorinated Blood Substitute

Fishman, Joel E.; Joseph, Peter M.; Carvlin, Mark J.; Saadi-Elmandjra, Mohamed; Mukherji, Biswanath; Sloviter, Henry A.

doi:10.1097/00004424-198901000-00014

Cited by 61 publications

(65 citation statements)

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“…Following IV infusion, a typical blood substitute emulsion circulates in the vasculature with a half-life of 12 h providing substantial clearance within 2 days [227]. Some investigators have examined tissue vascular pO 2 , while PFC remained in the blood [206,[232][233][234][235]. Flow can generate artifacts and correction algorithms have been proposed [236,237].…”

Section: U N C O R R E C T E D P R O O Fmentioning

confidence: 99%

VatuximabTM: Optimizing Therapeutic Strategies for Prostate Cancer Based on Dynamic MR Tumor Oximetry

Mason¹

2007

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Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS.

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Section: U N C O R R E C T E D P R O O Fmentioning

confidence: 99%

VatuximabTM: Optimizing Therapeutic Strategies for Prostate Cancer Based on Dynamic MR Tumor Oximetry

Mason¹

2007

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“…To overcome the above restrictions, I engaged in the development of fundamental techniques towards innovative molecular imaging technologies. This review focuses on two topics from our recent studies: (1) smart 19 F magnetic resonance imaging (MRI) probes that detect enzyme activities and (2) a versatile protein labeling technology that combines proteins of interest (POIs) with various functional molecules. The former study aims towards in vivo imaging applications by exploiting the MRI apparatus, whereas the latter connects protein engineering technology with a large number of functional imaging probes.…”

Section: Introductionmentioning

confidence: 99%

“…Overview of 19 F MRI Studies Real-time imaging of enzyme activities in vivo offers valuable information on living systems and aids in the development of medicine for various types of diseases. General fluorescence imaging methods are not suitable for in vivo studies because fluorescence does not transmit well through animal bodies and strong autofluorescence hinders the probe's fluorescence signals.…”

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confidence: 99%

“…For this purpose, some groups have reported smart 1 H MRI probes that detect pH, 6,7) metal ions, 8,9) or enzyme activities. [10][11][12][13] 19 F MRI has been studied for several decades. In the 1970s, the first example of 19 F MRI, which involved images of NaF and perfluoro compounds, was reported.…”

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confidence: 99%

“…[10][11][12][13] 19 F MRI has been studied for several decades. In the 1970s, the first example of 19 F MRI, which involved images of NaF and perfluoro compounds, was reported. 15) Since then, a significant number of 19 F MRI studies have been reported.…”

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Development of Molecular Imaging Tools to Investigate Protein Functions by Chemical Probe Design

Mizukami

2011

CHEMICAL & PHARMACEUTICAL BULLETIN

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Molecular imaging technologies, which enable the visualization of the behaviors or functions of biomolecules in living systems, have received considerable attention from life scientists. Novel imaging technologies that overcome the limitations of current imaging techniques are desired. In this review, two independent technologies that were recently developed by the authors are described. The first technology is for smart 19 F magnetic resonance imaging (MRI) probes that were developed for in vivo applications. These probes were developed by exploiting paramagnetic relaxation enhancement in order to detect hydrolase activity. With respect to cellular applications, gene expression in cells was visualized using one of the 19 F MRI probes. It was confirmed that this probe design principle is effective for various hydrolases, and broad applications are expected. The second technology is for practical protein labeling. This labeling method is based on a mutant b b -lactamase and its specific labeling probes. Since the probe is fluorescence resonance energy transfer (FRET)-based, this labeling method achieves both specific and fluorogenic labeling of target proteins. In addition, derivatization of the probe enabled the labeling of intracellular proteins and the modification of various functional molecules.

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Hexafluorobenzene: a Sensitive19F NMR Indicator of Tumor Oxygenation

1996

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In Vivo Measurements of Vascular Oxygen Tension in Tumors Using MRI of a Fluorinated Blood Substitute

Cited by 61 publications

References 0 publications

VatuximabTM: Optimizing Therapeutic Strategies for Prostate Cancer Based on Dynamic MR Tumor Oximetry

VatuximabTM: Optimizing Therapeutic Strategies for Prostate Cancer Based on Dynamic MR Tumor Oximetry

Development of Molecular Imaging Tools to Investigate Protein Functions by Chemical Probe Design

Hexafluorobenzene: a Sensitive19F NMR Indicator of Tumor Oxygenation

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