In vivo measurements of the elastic mechanical properties of human skin by indentation tests

Pailler-Mattéi, C.; Bec, Sandrine; Zahouani, H.

doi:10.1016/j.medengphy.2007.06.011

Cited by 570 publications

(375 citation statements)

References 35 publications

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“…Thus, excising the skin during biopsy and mechanical insults exerted during slicing can potentially affect the hydration status of the skin, as well as causing tension changes within this elastic tissue [66], while removal of the MN array before addition of the dye can also cause skin retraction and, therefore, pore deformation, which will ultimately affect the measured dimensions of the microconduits [5]. Furthermore, it is often difficult to locate the MN perforation in the skin sample due to the irregular nature of this tissue, as illustrated in the figure.…”

Section: Histological Tissue Staining and Sectioningmentioning

confidence: 99%

Microneedle characterisation: the need for universal acceptance criteria and GMP specifications when moving towards commercialisation

Lutton

Moore

Larrañeta

et al. 2015

Drug Deliv. and Transl. Res.

105

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Section: Histological Tissue Staining and Sectioningmentioning

confidence: 99%

Microneedle characterisation: the need for universal acceptance criteria and GMP specifications when moving towards commercialisation

Lutton

Moore

Larrañeta

et al. 2015

Drug Deliv. and Transl. Res.

105

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“…The stress distribution on skin deformation was measured in vivo by tension, torsion, suction and indentation tests [66][67][68][69]. These data were recently used to elaborate skin models for adhesion test, which kept into account the skin deformability [22,[70][71][72] and rugosity [73,74].…”

Section: Prediction Of Patch In Vivo Adhesive Performancesmentioning

confidence: 99%

Adhesive properties: a critical issue in transdermal patch development

Cilurzo

Gennari

Minghetti

2011

Expert Opinion on Drug Delivery

116

113

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“…[7][8][9] The small sample size is another reason which might be related to the samples and multi-layered structure of the skin tissues. 10,11 These limitations trigger bounding the application of biaxial tensile tests in determining the mechanical properties of soft biological tissues. The recently reported constitutive equations showed that the uniaxial tests on 2 orthogonally cut samples enable us to determine the anisotropic mechanical properties of soft biological tissues same as that achieved by biaxial tests.…”

Section: Introductionmentioning

confidence: 99%

“…7,12 The mechanical properties of the skin tissue so far have been measured by applying deformation forces, including traction, tension, suction, torsion or indentation in various ways to the skin samples. 11,13,14 Uniaxial extension setups are beneficial as the can be used to evaluate in-plane directional differences in material properties and can be non-invasive, applicable and easy to use in vivo. 15 Characterization of the mechanical properties of murine (rat or mice) skin would be important to allow its use as an animal model for human skin diseases.…”

Section: Introductionmentioning

confidence: 99%

Mechanical characterization of the rat and mice skin tissues using histostructural and uniaxial data

2015

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The skin tissue has been shown to behave like a nonlinear anisotropic material. This study was aimed to employ a constitutive fiber family equation to characterize the nonlinear anisotropic mechanical behavior of the rat and mice skin tissues in different anatomical locations, including the abdomen and back, using histostructural and uniaxial data. The rat and mice skin tissues were excised from the animals' body and then the histological analyses were performed on each skin type to determine the mean fiber orientation angle. Afterward, the preconditioned skin tissues were subjected to a series of quasi-static axial and circumferential loads until the incidence of failure. The crucial role of fiber orientation was explicitly added into a proposed strain energy density function. The material coefficients were determined using the constrained nonlinear optimization method based on the axial and circumferential extension data of the rat and mice samples at different anatomical locations. The material coefficients of the skins were given with R 2 0.998. The results revealed a significant load-bearing capacity and stiffness of the rat abdomen compared to the rat back tissues. In addition, the mice abdomen showed a higher stiffness in the axial direction in comparison with circumferential one, while the mice back displayed its highest stiffness in the circumferential direction. The material coefficients of the rat and mice skin tissues were determined and well compared to the experimental data. The optimized fiber angles were also compared to the experimental histological data, and in all cases less than 11.85% differences were observed in both the skin tissues.

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In vivo measurements of the elastic mechanical properties of human skin by indentation tests

Cited by 570 publications

References 35 publications

Microneedle characterisation: the need for universal acceptance criteria and GMP specifications when moving towards commercialisation

Microneedle characterisation: the need for universal acceptance criteria and GMP specifications when moving towards commercialisation

Adhesive properties: a critical issue in transdermal patch development

Mechanical characterization of the rat and mice skin tissues using histostructural and uniaxial data

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