In vivo measurement of <sup>32</sup>P in the brain of a freely moving rat

Mayevsky, Avraham; Samuel, David; Friedland, Stephen S.; Ewins, J.H.

doi:10.1002/jnr.490010309

J of Neuroscience Research

1975

DOI: 10.1002/jnr.490010309

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In vivo measurement of ³²P in the brain of a freely moving rat

Avraham Mayevsky

David Samuel

Stephen S. Friedland

et al.

Abstract: A new method for measuring the uptake of materials labeled with radioactive phosphorus (32P) in the brain of a freely moving rat is described. The rate of uptake in the brain of a single animal of 32P-labeled phosphate was compared to the uptake rate in the animal's blood or liver. A comparison was made between the uptake following an intravenous (IV) or an intraperitoneal (IP) injection. The effect of convulsions caused by injections of metrazol on the kinetics of 32P uptake in the brain is described.

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2011

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MITOCHONDRIAL FUNCTION AND TISSUE VIABILITYIN VIVO: FROM ANIMAL EXPERIMENTS TO CLINICAL APPLICATIONS. FORTY YEARS OF FRUITFUL COLLABORATION WITH BRITTON CHANCE

Mayevsky

2011

J. Innov. Opt. Health Sci.

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The involvement of mitochondrial dysfunction in many pathophysiological conditions and human diseases is well documented. In order to evaluate mitochondrial function in vitro, many experimental systems have been developed. Nevertheless the number of in vivo monitoring systems for the evaluation of mitochondrial activities in intact animals and patients is relatively limited. The pioneering development of the conceptual and technological aspects of mitochondrial monitoring, in vitro and in vivo, was done by the late Prof. Britton Chance (July 24, 1913–November 16, 2010) since the early 1950s. It was my privilege to join his laboratory in 1972 and collaborate with him for almost four decades. The main achievements of our collaboration are presented in this paper. Our activities included cycles of technology development, followed by its applications to study various pathophysiological conditions. In the initial stage, the first fiber-optic–based NADH fluorometer was developed. This device enabled us to monitor various organs in anesthetized animals as well as the brain of nonanesthetized small animals. Later on, the addition of various physiological parameters to NADH monitoring enabled us to correlate mitochondrial function with other cellular functions. The application of the developed technology to clinical situations was a major interest of Prof. Chance and indeed this goal was achieved in the last decade. As of today, the basic tool for NADH monitoring and the large database of results are available for large-scale experimental and clinical applications.

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MITOCHONDRIAL FUNCTION AND TISSUE VIABILITYIN VIVO: FROM ANIMAL EXPERIMENTS TO CLINICAL APPLICATIONS. FORTY YEARS OF FRUITFUL COLLABORATION WITH BRITTON CHANCE

Mayevsky

2011

J. Innov. Opt. Health Sci.

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show abstract

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In vivo measurement of ³²P in the brain of a freely moving rat

Cited by 1 publication

References 10 publications

MITOCHONDRIAL FUNCTION AND TISSUE VIABILITYIN VIVO: FROM ANIMAL EXPERIMENTS TO CLINICAL APPLICATIONS. FORTY YEARS OF FRUITFUL COLLABORATION WITH BRITTON CHANCE

MITOCHONDRIAL FUNCTION AND TISSUE VIABILITYIN VIVO: FROM ANIMAL EXPERIMENTS TO CLINICAL APPLICATIONS. FORTY YEARS OF FRUITFUL COLLABORATION WITH BRITTON CHANCE

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In vivo measurement of 32P in the brain of a freely moving rat

Cited by 1 publication

References 10 publications

MITOCHONDRIAL FUNCTION AND TISSUE VIABILITYIN VIVO: FROM ANIMAL EXPERIMENTS TO CLINICAL APPLICATIONS. FORTY YEARS OF FRUITFUL COLLABORATION WITH BRITTON CHANCE

MITOCHONDRIAL FUNCTION AND TISSUE VIABILITYIN VIVO: FROM ANIMAL EXPERIMENTS TO CLINICAL APPLICATIONS. FORTY YEARS OF FRUITFUL COLLABORATION WITH BRITTON CHANCE

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In vivo measurement of ³²P in the brain of a freely moving rat