In vivo measurement of plaque neovascularisation and thermal heterogeneity in intermediate lesions of human carotid arteries

Toutouzas, Konstantinos; Drakopoulou, Maria; Aggeli, Constantina; Nikolaou, Charalampia; Felekos, Ioannis; Grassos, Haralampos; Synetos, Αndreas; Stathogiannis, Konstantinos; Καρανάσος, Αντώνιος; Tsiamis, Eleftherios; Σιώρης, Ηλίας; Stefanadis, Christodoulos

doi:10.1136/heartjnl-2012-302507

Cited by 19 publications

(17 citation statements)

References 30 publications

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“…Temperature difference (ΔT) of each carotid artery was assigned as the temperature of the target segment minus the minimal temperature of each carotid (reference temperature) as previously determined. 3,6,7 …”

Section: Microwave Radiometry Measurementsmentioning

confidence: 99%

“…Basic principles of MWR have been previously described. 3,6,7 MWR measurements were performed at both culprit and nonculprit carotid arteries over the segments previously defined in ultrasound imaging, including the target segments. Temperature difference (ΔT) of each carotid artery was assigned as the temperature of the target segment minus the minimal temperature of each carotid (reference temperature) as previously determined.…”

Section: Microwave Radiometry Measurementsmentioning

confidence: 99%

“…3,[6][7][8] Both extracranial carotid and vertebral arteries were examined with a high resolution B-mode ultrasound unit (Philips iEE33 ultrasound machine, Philips, Bothell, Washington), using a 7.5-MHz transducer. Carotid plaques were defined according to previously used definitions.…”

Section: Ultrasound Imagingmentioning

confidence: 99%

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Incremental Predictive Value of Carotid Inflammation in Acute Ischemic Stroke

Toutouzas

Benetos

Drakopoulou

et al. 2015

Stroke

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Background and Purpose-Microwave Radiometry (MWR) allows in vivo noninvasive assessment of internal temperature of tissues. The aim of the present study was to evaluate in patients with ischemic stroke and bilateral carotid plaques (1) whether ipsilateral carotid arteries exhibit higher temperature differences (ΔT), as assessed by MWR; (2) the predictive accuracy of MWR in symptomatic carotid artery identification. Methods-Consecutive patients with recent acute anterior circulation ischemic stroke because of large artery atherosclerosis were included in the study. Carotid arteries of all patients were evaluated by carotid ultrasound and MWR. Results-In total, 50 patients were included in the study. Culprit carotid arteries had higher ΔT compared with nonculprit (0.93±0.58 versus 0.58±0.35°C; P<0.001).

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Section: Microwave Radiometry Measurementsmentioning

confidence: 99%

Section: Microwave Radiometry Measurementsmentioning

confidence: 99%

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Incremental Predictive Value of Carotid Inflammation in Acute Ischemic Stroke

Toutouzas

Benetos

Drakopoulou

et al. 2015

Stroke

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“…The basic principles of MR have been described previously. 5,6 Temperature measurements were performed at each carotid artery over the previously defined segments (20 mm each). The method has been validated as described previously.…”

Section: Mr Measurementsmentioning

confidence: 99%

“…Microwave radiometry (MR) is a new method and allows in vivo noninvasive measurement of the temperature of carotid atherosclerotic plaques, reflecting their inflammatory status. [5][6][7] In the present study, we aimed to (1) examine whether the inflammation of carotid artery wall, as assessed by MR, correlates with the presence of CAD, and (2) compare the predictive value of the morphological and functional assessment of carotid plaques in CAD detection. …”

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confidence: 99%

Morphological and Functional Assessment of Carotid Plaques Have Similar Predictive Accuracy for Coronary Artery Disease

Toutouzas

Benetos

Drakopoulou

et al. 2013

Stroke

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C arotid intima-media thickness (IMT) has been widely used as a surrogate marker for coronary artery disease (CAD). [1][2][3][4] The increase of IMT in carotid arterial wall reflects morphological alterations and does not provide information on the functional changes. Microwave radiometry (MR) is a new method and allows in vivo noninvasive measurement of the temperature of carotid atherosclerotic plaques, reflecting their inflammatory status. [5][6][7] In the present study, we aimed to (1) examine whether the inflammation of carotid artery wall, as assessed by MR, correlates with the presence of CAD, and (2) compare the predictive value of the morphological and functional assessment of carotid plaques in CAD detection. Methods Study PopulationConsecutive patients undergoing coronary angiography were prospectively enrolled in the study. Significant CAD was defined as diameter lumen stenosis of ≥50% in ≥1 major coronary artery. Multivessel CAD was defined as the presence of significant stenoses in ≥2 major coronary arteries.All patients underwent carotid ultrasound examination followed by MR measurements, performed by specialists blinded to angiographic results. All participants provided informed consent, and the study was approved by our institution ethical committee. Ultrasound ImagingThe ultrasound protocol included scanning of both carotid arteries from their point of origin throughout their whole length using a 7.5-MHz transducer (Philips iEE33; Philips, Washington). IMT measurements were performed in 3 segments of 20 mm along each carotid artery. For this purpose, the middle segment was the region of common carotid bifurcation and was used as a marker. The regions 20 mm proximal and 20 mm distal to the bifurcation region defined the 2 other segments, namely the common carotid artery segment and the internal carotid artery segment, respectively. The highest IMT value of all segments of both carotid arteries was defined as IMT max .Background and Purpose-Microwave radiometry allows noninvasive in vivo measuring of internal temperature of tissues reflecting inflammation. In the present study, we evaluated the predictive accuracy of this method for the diagnosis of coronary artery disease (CAD). Methods-Consecutive patients (n=287) scheduled for coronary angiography were included in the study. In carotid arteries of both groups, the following measurements were performed: (1) intima-media thickness (IMT max ) and (2) temperature measurements by microwave radiometry (ΔT max ). C-statistic and net reclassification improvement were used to compare the prediction ability of the markers IMT max and ΔT max for the presence of CAD and multivessel CAD. Results-Of 287 patients, 239 had stenoses ≥50% (CAD group), and 48 did not have significant stenoses (NO-CAD group).ΔT max was an independent predictor for the presence of CAD and multivessel CAD, showing similar predictive accuracy to intima-media thickness, as assessed by c-statistic and net reclassification improvement. Conclusions-Local inflammatory activation, as dete...

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Noninvasive detection of increased carotid artery temperature in patients with coronary artery disease predicts major cardiovascular events at one year: Results from a prospective multicenter study

Toutouzas¹,

Benetos²,

Koutagiar³

et al. 2017

Atherosclerosis

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In vivo measurement of plaque neovascularisation and thermal heterogeneity in intermediate lesions of human carotid arteries

Abstract: Carotid plaque neovascularisation on CEUS examination is associated with increased thermal heterogeneity and ultrasound characteristics of plaque vulnerability in intermediate lesions.

Cited by 19 publications

References 30 publications

Incremental Predictive Value of Carotid Inflammation in Acute Ischemic Stroke

Incremental Predictive Value of Carotid Inflammation in Acute Ischemic Stroke

Morphological and Functional Assessment of Carotid Plaques Have Similar Predictive Accuracy for Coronary Artery Disease

Noninvasive detection of increased carotid artery temperature in patients with coronary artery disease predicts major cardiovascular events at one year: Results from a prospective multicenter study

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