In Vivo Measurement of H2S, Polysulfides, and “SSNO− Mix”-Mediated Vasoactive Responses and Evaluation of Ten Hemodynamic Parameters from Rat Arterial Pulse Waveform

Kristek, F; Grman, Marian; Ondriaš, Karol

doi:10.1007/978-1-4939-9528-8_8

Cited by 6 publications

(7 citation statements)

References 19 publications

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“…This work is a continuation of our previous studies examining the hypothesis that it is possible to characterize cardiovascular system in many patho-physiological conditions just from the shape of APW [22,23,27]. For the characterization of the cardiovascular system, numerous "patterns" of HPs and their cross-relationships derived from APW must be known in order to create a database of unique patterns for various cardiovascular conditions.…”

Section: Discussionmentioning

confidence: 93%

Characterization of Rat Cardiovascular System by Anacrotic/Dicrotic Notches in the Condition of Increase/Decrease of NO Bioavailability

Tomášová

Misak

Kurakova

et al. 2020

IJMS

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We characterized modes of action of NO-donor S-nitrosoglutathione (GSNO) and NO-synthase inhibitor l-NAME derived from dicrotic (DiN) and anacrotic (AnN) notches of rat arterial pulse waveform (APW) in the condition of increased/decreased NO bioavailability. The cross-relationship patterns of DiN and AnN with 34 hemodynamic parameters (HPs) induced by GSNO and l-NAME are presented. After GSNO bolus administration, approximate non-hysteresis relationships were observed in the difference between DiN–AnN (mmHg) blood pressure (BP) and other 19 HPs, suggesting that these HPs, i.e., their signaling pathways, responding to NO concentration, are directly connected. Hysteresis relationships were observed between DiN-AnN (mmHg) and other 14 HPs, suggesting that signaling pathways of these HPs are indirectly connected. The hysteresis relationships were only observed between the time interval DiN-AnN (ms) and other 34 HPs, indicating no direct connection of signaling pathways. The cross-relationship patterns of DiN-AnN (mmHg), but not DiN-AnN (ms), induced by l-NAME were in accordance to the increased NO bioavailability induced by GSNO. In conclusion, we found the non-hysteresis/hysteresis cross-relationship “patterns” of DiN-AnN intervals to other HPs in the presence of GSNO that revealed their direct or indirect signaling pathways connections. This may contribute to our understanding of biological effects of natural substances that modulate NO production and/or NO signaling pathways.

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Section: Discussionmentioning

confidence: 93%

Characterization of Rat Cardiovascular System by Anacrotic/Dicrotic Notches in the Condition of Increase/Decrease of NO Bioavailability

Tomášová

Misak

Kurakova

et al. 2020

IJMS

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“…Using the sensitive fibre‐optic probe allowed us to obtain APW at high pressure and time resolutions (details shown in Figure ; Kristek et al., ). We wrote an analysing program in the MATLAB programming language (The MathWorks Inc., Natick, MA, USA) to identify 10 specific points on APW (marked as a–j in Figure ) from which 35 HPs were defined (Table ).…”

Section: Methodsmentioning

confidence: 99%

“…Several APW parameters have been introduced to characterize the cardiovascular system and the connection of pathological conditions with haemodynamic parameters, e.g. the augmentation index, dicrotic notch position, reflection time and cardiac output (Avolio, Butlin, & Walsh, ; Kristek, Grman, & Ondrias, ; Lee et al., ; Lekakis et al., ; Marchais et al., ; Oliver & Webb, ; O'Rourke, Pauca, & Jiang, ; Zhang, Critchley, & Huang, ; Žikić, ).…”

Section: Introductionmentioning

confidence: 99%

“…Studies in this field have been focused on the relationships between particular APW parameters and the function of specific components of the cardiovascular system. Until now, few APW parameters have been used to study the relationships (Avolio et al., ; Chowienczyk et al., ; Codreanu et al., ; Kristek et al., ; Lee et al., ; Nelson et al., ; Stoner et al., ; Sueta et al., ; Vlachopoulos & O'Rourke, ; Zhang et al., ).…”

Section: Introductionmentioning

confidence: 99%

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Mathematical relationships of patterns of 35 rat haemodynamic parameters for conditions of hypertension resulting from decreased nitric oxide bioavailability

Kurakova

Misak

Tomášová

et al. 2020

Experimental Physiology

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Information obtained from the arterial pulse waveform (APW) using haemodynamic parameters (HPs) is useful for characterization of the cardiovascular system in particular (patho)physiological conditions. Our goal was to find out whether the relationships between rat HPs could be described by simple mathematical functions and to find mathematical parameters for conditions of high blood pressure (BP) resulting from decreased NO bioavailability. The right jugular vein of anaesthetized Wistar rats was cannulated for I.V. administration of N -nitro-L-arginine methyl ester (L-NAME). The left common carotid artery was cannulated to detect the APW. From 10 points on the rat APW we defined 35 HPs (some were known already) and found 595 crossrelationships between HPs showing unique patterns for particular cardiovascular conditions.Here we show parallel time-dependent changes of 35 HPs and some of their cross-relationships in condition of high BP induced by L-NAME. We found that most of the time-dependent changes of 35 HPs and their relationships were very well fitted by simple mathematical functions, e.g. a linear function, exponential growth, exponential decay or exponential rise to maximum. The results may enable the mathematical functions to be assigned for decreased NO bioavailability, which may have predictive or diagnostic value for conditions of high BP.Using this approach, it may be possible to find unique cross-relationship patterns of HPs and mathematical functions between HPs for different cardiovascular (patho)physiological or drugmodulating conditions. This knowledge can be used in studying the molecular mechanisms of particular (patho)physiological conditions or drug actions and may have predictive or diagnostic value. K E Y W O R D Smathematical relationships, NO bioavailability, pulse waveform parameters INTRODUCTIONThe information obtained from an arterial pulse waveform (APW) analysis, as shape, amplitude and duration of the waveform, can provide insight into many diseases, including hypertension, coronary artery disease, diabetes and diastolic dysfunction (Nelson et al.,The APW gives useful information on details of the cardiovascular system, e.g. mechanical properties of the arterial tree, arterial stiffness, ventricular-vascular interaction and endothelial function. Several APW parameters have been introduced to characterize the cardiovascular system and the connection of pathological conditions with haemodynamic parameters, e.g. the augmentation index, dicrotic notch position, reflection time and cardiac output (Avolio, Butlin, & Walsh, 312 wileyonlinelibrary.com/journal/eph Experimental Physiology. 2020;105:312-334. 2 MATERIALS AND METHODS 2.1 Ethical approval All procedures were approved by the State Veterinary and Food Administration of the Slovak Republic (No: Ro-1545/15-221) according to the guidelines of Directive 2010/63/EU of the European Parliament. The procurement of animals, the husbandry and the experiments conform to the 'European Convention for the Protection

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“…They proposed that S-nitrosothiols are transient intermediates that react with thiols to form stable persulfides [72]. The direct interaction between H 2 S and NO results in the formation of biologically active nitrosopersulfide and polysulfides [73][74][75][76]. In addition, H 2 S may interact with other reactive species, e.g., oxygen, nitrogen, sulfur and selenium species.…”

Section: H 2 S Signalingmentioning

confidence: 99%

Hydrogen Sulfide in Pharmacotherapy, Beyond the Hydrogen Sulfide-Donors

et al. 2020

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Hydrogen sulfide (H2S) is one of the important biological mediators involved in physiological and pathological processes in mammals. Recently developed H2S donors show promising effects against several pathological processes in preclinical and early clinical studies. For example, H2S donors have been found to be effective in the prevention of gastrointestinal ulcers during anti-inflammatory treatment. Notably, there are well-established medicines used for the treatment of a variety of diseases, whose chemical structure contains sulfur moieties and may release H2S. Hence, the therapeutic effect of these drugs may be partly the result of the release of H2S occurring during drug metabolism and/or the effect of these drugs on the production of endogenous hydrogen sulfide. In this work, we review data regarding sulfur drugs commonly used in clinical practice that can support the hypothesis about H2S-dependent pharmacotherapeutic effects of these drugs.

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In Vivo Measurement of H2S, Polysulfides, and “SSNO− Mix”-Mediated Vasoactive Responses and Evaluation of Ten Hemodynamic Parameters from Rat Arterial Pulse Waveform

Cited by 6 publications

References 19 publications

Characterization of Rat Cardiovascular System by Anacrotic/Dicrotic Notches in the Condition of Increase/Decrease of NO Bioavailability

Characterization of Rat Cardiovascular System by Anacrotic/Dicrotic Notches in the Condition of Increase/Decrease of NO Bioavailability

Mathematical relationships of patterns of 35 rat haemodynamic parameters for conditions of hypertension resulting from decreased nitric oxide bioavailability

Hydrogen Sulfide in Pharmacotherapy, Beyond the Hydrogen Sulfide-Donors

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