In vivo mapping of pulmonary lymphatic pathways: A new technique

Bethune, Drew; Chiu, Ray Chu‐Jeng; Mulder, David S.; Rosenthal, Leonard

doi:10.1016/0022-4804(79)90042-8

Cited by 6 publications

(2 citation statements)

References 7 publications

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“…Since Braithwaite's finding of blackened ileocaecal lymph nodes in a patient with appendicitis14, and Gray's conclusion following lymphography that focal lymph glands will be the ‘first and most likely seat of glandular metastases’15, lymphatic mapping has been steadily developed from blue dye mapping of gastric16 and breast17 cancers, to the identification of a ‘primary complex’ of lymph nodes draining penile carcinoma18. This technique was developed further in canine19 and feline20 models and led to the concept of selective lymphadenectomy. Following the success of Morton et al 21 with vital dye mapping, sentinel node mapping has been developed in malignant melanoma using a combination of lymphoscintigraphy and blue dye22–26.…”

Section: Introductionmentioning

confidence: 99%

Sentinel lymph node mapping in colorectal cancer

Mulsow

Winter

O’Keane

et al. 2003

British Journal of Surgery

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Section: Introductionmentioning

confidence: 99%

Sentinel lymph node mapping in colorectal cancer

Mulsow

Winter

O’Keane

et al. 2003

British Journal of Surgery

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“…Braithwaite injected blue dye in various locations of the abdominal cavity in human patients and described "glands sentinel" as the recipients of lymph flow from the injected location [1]. Several other investigators experimented with colored dyes, radiopaque contrast, and radioactive material [2][3][4][5][6][7][8][9][10][11][12][13]. The current concepts of the utility of the SN were reported by Cabanas in 1977 [14].…”

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confidence: 99%

Radiolabeled Sentinel Node Biopsy: Collaborative Trial with the National Cancer Institute

et al. 2001

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The objective of this study was to maximize the success rate of sentinel node (SN) localization in breast cancer patients with the tracer that demonstrated the highest initial success during a preliminary evaluation. Altogether, 145 patients with operable invasive breast cancer and clinically negative lymph nodes were studied. Technetium 99m (99mTc)-sulfur colloid was injected into the breast parenchyma surrounding the invasive cancer or the biopsy cavity. Variable volumes of tracer, amounts of 99mTc, and duration of time between injection and surgery were evaluated. A hand-held gamma detector was used at surgery to locate and guide resection of all radioactive sentinel nodes (SNs), including those that were extraaxillary. A conventional lymphadenectomy was then performed in all cases. Based on previous studies, unfiltered sulfur colloid provided a higher success rate of SN identification than the other tracer types. Further evaluation with 99mTc-sulfur colloid demonstrated that increased volume increased the success rate of SN identification. An injection volume of 8 ml resulted in a success rate of 98%. SNs were not exclusively located in the axilla: In 8.6% of cases SNs were removed from an internal mammary location. The overall accuracy of patients with SNs resected was 98.4%, and the false-negative rate was 4.4%. It was concluded that (1) unfiltered 99mTc-sulfur colloid at a volume of 8 ml resulted in a high success rate for SN identification; (2) a significant number of the SNs were extraaxillary in location; and (3) the accuracy of the SNs for determining whether regional metastases had occurred was high. The U.S. National Cancer Institute is funding a randomized phase III clinical trial to evaluate SN resection compared to conventional axillary lymphadenectomy in clinical node-negative breast cancer patients. Major endpoints of this trial include long-term regional control and survival.

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Other applications of interstitial lymphoscintigraphy

McConnell

Kim

1983

Seminars in Nuclear Medicine

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In vivo mapping of pulmonary lymphatic pathways: A new technique

Cited by 6 publications

References 7 publications

Sentinel lymph node mapping in colorectal cancer

Sentinel lymph node mapping in colorectal cancer

Radiolabeled Sentinel Node Biopsy: Collaborative Trial with the National Cancer Institute

Other applications of interstitial lymphoscintigraphy

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