2021
DOI: 10.1101/2021.02.05.429612
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In vivo magnetic resonance spectroscopy of hyperpolarized [1-13C] pyruvate in a male guinea pig model of life-long Western diet consumption and non-alcoholic fatty liver disease development

Abstract: BACKGROUND: Alterations in glycolysis and oxidative pathways are central to the increasing incidence of non-alcoholic fatty liver disease (NAFLD), independent of body composition changes, highlighting a need for in vivo, non-invasive technologies to understand the development of hepatic metabolic aberrations in lean NAFLD. PURPOSE/HYPOTHESIS: To use hyperpolarized magnetic resonance spectroscopy (MRS) and proton density fat fraction (PDFF) MRI techniques to investigate effects of chronic, lifelong exposure to … Show more

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