In Vivo Magnetic Resonance Imaging Evaluation of Porous Tantalum Interbody Fusion Devices in a Porcine Spinal Arthrodesis Model

Zhou, Zhiyu; Wei, Fuxin; Huang, Sheng; Gao, Manman; Li, Haisheng; Stødkilde-Jørgensen, Hans; Lind, Martin; Bünger, Cody; Zou, Xuenong

doi:10.1097/brs.0000000000001068

Cited by 12 publications

(6 citation statements)

References 28 publications

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“…The risk of bias for accuracy studies was low in 2 studies 22,23 and high in 1 (Appendix C) 24 . None of the reliability studies met the criteria for “high” quality.…”

Section: Resultsmentioning

confidence: 99%

“…The intraobserver evaluation correlation of 3 observers was 0.602, 0.789, and 0.505 between the Lenke and Bridwell classifications; 0.639, 0.825, and 0.535 between the Lenke and Bratingan-Steffee-Fraser (BSF) classifications; and 0.685, 0.825, and 0.026 between the Bridwell and BSF classifications 29 (see Table II for a description of the classifications). Reported interobserver agreement for the descriptive criteria was usually strong or almost perfect 22,23,25-29 . Interobserver agreement for the classifications was reported poor by one study and good by another 29 .…”

Section: Resultsmentioning

confidence: 99%

“…Seven studies assessed interobserver reliability between observers for descriptive criteria 22,23,25-29 and 2 studies for classifications 24,29 (Table IV). Most studies used κ values.…”

Section: Resultsmentioning

confidence: 99%

“…Other measures of reliability were only reported incidentally. Zhou et al reported an intraclass correlation coefficient for intraobserver reliability of 0.90 (CI 0.85-0.93) for radiolucency around the cage detected from signal intensity measurements on MRI, with an analysis interval of 6 months 23 .…”

Section: Resultsmentioning

confidence: 99%

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Radiologic Assessment of Interbody Fusion

Duits,

van Urk,

Lehr

et al. 2024

JBJS Reviews

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Background: Lumbar interbody fusion (IF) is a common procedure to fuse the anterior spine. However, a lack of consensus on image-based fusion assessment limits the validity and comparison of IF studies. This systematic review aims to (1) report on IF assessment strategies and definitions and (2) summarize available literature on the diagnostic reliability and accuracy of these assessments. Methods: Two searches were performed according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. Search 1 identified studies on adult lumbar IF that provided a detailed description of image-based fusion assessment. Search 2 analyzed studies on the reliability of specific fusion criteria/classifications and the accuracy assessed with surgical exploration. Results: A total of 442 studies were included for search 1 and 8 studies for search 2. Fusion assessment throughout the literature was highly variable. Eighteen definitions and more than 250 unique fusion assessment methods were identified. The criteria that showed most consistent use were continuity of bony bridging, radiolucency around the cage, and angular motion <5°. However, reliability and accuracy studies were scarce. Conclusion: This review highlights the challenges in reaching consensus on IF assessment. The variability in IF assessment is very high, which limits the translatability of studies. Accuracy studies are needed to guide innovations of assessment. Future IF assessment strategies should focus on the standardization of computed tomography–based continuity of bony bridging. Knowledge from preclinical and imaging studies can add valuable information to this ongoing discussion. Level of Evidence: Diagnostic Level III. See Instructions for Authors for a complete description of levels of evidence.

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“…The risk of bias for accuracy studies was low in 2 studies 22,23 and high in 1 (Appendix C) 24 . None of the reliability studies met the criteria for “high” quality.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Seven studies assessed interobserver reliability between observers for descriptive criteria 22,23,25-29 and 2 studies for classifications 24,29 (Table IV). Most studies used κ values.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Radiologic Assessment of Interbody Fusion

Duits,

van Urk,

Lehr

et al. 2024

JBJS Reviews

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“…Moreover, large animal discs for interbody fusion have strong resemblance to human bony structures which allow the insertion of actual clinical instruments into the pedicles [27] , [28] , and are capable of investigating the feasibility of robotic assisted surgery [29] . Also, large animal models provide better evaluation for fusion status when using same setting for CT and MRI assessments [30] . On the other hand, small animal discs are often used to investigate the effect of drug treatment and growth factor supplementation even in ovariectomized model due to short generation time, high metabolic rate, and easy to manipulation for small animals [8] , [31] , [32] .…”

Section: Discussionmentioning

confidence: 99%

Characterization of a novel caudal vertebral interbody fusion in a rat tail model: An implication for future material and mechanical testing

et al. 2017

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BackgroundOf the proposed animal interbody fusion models, rat caudal discs have gained popularity in disc research due to their strong resemblance to human discs with respect to geometry, composition and mechanical properties. The purpose of this study is to demonstrate an efficient, repeatable and easily accessible animal model of interbody fusion for future research into mechanical testing and graft materials.MethodsTwelve 12-week-old female Sprague–Dawley (SD) rats underwent caudal interbody fusion of the third and fourth coccygeal vertebrae of the tail. Serial radiological evaluation, and histological evaluation and manual palpation after sacrifice were performed to assess the fusion quality. Mechanical testing of functional units (FUs) of non-operated and operated segments was compared using a three-point bending test.ResultsAt postoperative 12 weeks, callus formation was observed at the fusion sites in all rats, with the mean radiological evaluations of 2.75/3 according to the Bransford classification. Newly formed bone tissue was also observed in all rats with the mean histological score of 5.85/7, according to the Emery grading system. No palpable gaps and obvious change of bending stiffness was observed in the operated segments. The mean bending stiffness of the FUs was statistically higher than that of the control FUs (26.57 ± 6.71 N/mm vs. 12.45 ± 3.21 N/mm, p < 0.01).ConclusionThe rat caudal disc interbody fusion model proved to be an efficient, repeatable and easily accessible model. Future research into adjuvant treatments like growth factor injection and alternative fusion materials under conditions of osteoporosis using this model would be worthwhile.

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Epidural pressure measurement using a fiber‐optic sensor (proof‐of‐principle in vivo animal trial)

Barz,

Friedemann,

Voigt

et al. 2024

Anim Models and Exp Med

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BackgroundAn increase in epidural pressure around the stenosis has been observed in patients with lumbar spinal stenosis (LSS) with positive signs of sedimentation or redundant nerve roots. Further analysis of the pressure conditions in the stenotic area would be of great interest. We hypothesized that it would be possible to determine the physiological parameters of the epidural pulse wave and its course in pathological stenosis as a basis for objective identification of LSS based on pressure using a new measuring method with continuous spatial and temporal resolution.MethodsWe performed a single‐case proof‐of‐principle in vivo animal trial and used a newly developed hybrid pressure‐measurement probe with a fiber‐tip Fabry–Pérot interferometer and several fiber Bragg gratings (FBG).ResultsWith reproducible precision, we determined the mean epidural pressure to be 7.5 mmHg and the peak‐to‐peak value to be 4–5 mmHg. When analyzing the pressure measured by an FBG array, both the heart and respiratory rates can be precisely determined. This study was the first to measure the pulse wave velocity of the cerebrospinal fluid pressure wave as 0.97 m/s using the newly developed pressure probe. A simulated LSS was detected in real time and located exactly.ConclusionsThe developed fiber‐optic pressure sensor probe enables a new objective measurement of epidural pressure. We confirmed our hypothesis that physiological parameters of the epidural pulse wave can be determined and that it is possible to identify an LSS.

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In Vivo Magnetic Resonance Imaging Evaluation of Porous Tantalum Interbody Fusion Devices in a Porcine Spinal Arthrodesis Model

Abstract: N/A.

Cited by 12 publications

References 28 publications

Radiologic Assessment of Interbody Fusion

Radiologic Assessment of Interbody Fusion

Characterization of a novel caudal vertebral interbody fusion in a rat tail model: An implication for future material and mechanical testing

Epidural pressure measurement using a fiber‐optic sensor (proof‐of‐principle in vivo animal trial)

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