In vivo magnetic resonance evaluation of associations between aortic atherosclerosis and both risk factors and coronary artery disease in patients referred for coronary angiography

Taniguchi, Hiroaki; Momiyama, Yukihiko; Fayad, Zahi A.; Ohmori, Reiko; Ashida, Kazuhiro; Kihara, Teruyoshi; Hara, Akiko; Arakawa, Koh; Kameyama, Akira; Noya, Kumiko; Nagata, Masayoshi; Nakamura, Haruo; Ohsuzu, Fumitaka

doi:10.1016/j.ahj.2004.03.008

Cited by 68 publications

(70 citation statements)

References 31 publications

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“…The imaging parameters were TR 2 RR intervals, TE 10 ms (PDW) and 60 ms (T2W), 20-cm FOV, 4-mm slice thickness, 8-mm inter-slice gap, 256x256 acquisition matrix, and 32 echo-train. As in our previous studies 14,15) , 9 slices of the thoracic aorta and 9 slices of the abdominal aorta were obtained at 12-mm intervals, which each covering about a 10-cm portion of the thoracic aorta below the aortic arch and a 10-cm portion of the abdominal aorta above the bifurcation of the common iliac artery (Fig. 1).…”

Section: Mri Of the Aortamentioning

confidence: 99%

“…Our study consisted of 136 patients (105 man; mean age 64 9 years, range 40 to 85 years) undergoing elective coronary angiography for suspected or known CAD at the National Defense Medical College Hospital, of whom 102 were included in our previous study 14) . Patients with acute coronary syndrome, with a history of cardiovascular surgery, with aortic disease, valvular heart disease or congenital heart disease, or with any inflammatory disease or malignancy were excluded from our study, which was approved by the institutional ethics committee.…”

Section: Study Patientsmentioning

confidence: 99%

“…In humans, we reported that MRI evaluation of thoracic aorta closely correlated with transesophageal echocardiography (TEE) findings 13) . Using MRI, we previously investigated the associations of thoracic and abdominal aortic plaque with atherosclerotic risk factors and plasma hsCRP levels in 102 patients 14) , and that hsCRP levels correlated with the extent of thoracic and abdominal aortic plaque. Therefore, the present study extended our previous study by showing the associations between plasma hsCRP levels and the severities of both coronary and aortic atherosclerosis in 136 patients undergoing coronary angiography and aortic MRI and by elucidating which severity of coronary or aortic atherosclerosis is more closely related to hsCRP levels.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, magnetic resonance imaging (MRI) has become a useful tool for non-invasively evaluating atherosclerotic plaques in both the thoracic and abdominal aortas [13][14][15][16] . We 17,18) and others 19) have shown good correlations regarding the aortic plaque extent between in vivo and ex vivo MRI findings and histopathology in animal models.…”

Section: Introductionmentioning

confidence: 99%

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Associations Between Plasma C-reactive Protein Levels and the Severities of Coronary and Aortic Atherosclerosis

Momiyama¹,

Ohmori²,

Fayad³

et al. 2010

JAT

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Aim:Limited correlations between C-reactive protein (CRP) and coronary artery disease (CAD) have been reported. Recently, MRI became a useful tool for non-invasively evaluating atherosclerotic plaques in thoracic and abdominal aortas. Methods: To elucidate the associations between plasma CRP levels and the severities of coronary and aortic atherosclerosis, we performed aortic black-blood MRI in 136 patients undergoing coronary angiography. For each patient, 9 slices of thoracic aorta and 9 slices of abdominal aorta were obtained at 12-mm intervals, and the plaque extent in each slice was scored. The degree of aortic atherosclerosis is represented as the sum of scores. The degree of coronary atherosclerosis is represented as the number of 50% stenotic vessels and 25% stenotic segments.

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Section: Mri Of the Aortamentioning

confidence: 99%

Section: Study Patientsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Associations Between Plasma C-reactive Protein Levels and the Severities of Coronary and Aortic Atherosclerosis

Momiyama¹,

Ohmori²,

Fayad³

et al. 2010

JAT

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“…[19][20][21][22] Fibrinogen is especially associated with atherosclerosis and vascular occlusive pathologies. 20,23 In the South African population, hypertension is more prevalent in urban black Africans compared to Caucasians, Indians and those of mixed origin. 24,25 This is also the case in African Americans and Caribbean Africans living in the UK.…”

Section: Introductionmentioning

confidence: 99%

Inflammation, obesity and cardiovascular function in African and Caucasian women from South Africa: the POWIRS study

et al. 2006

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The integrated relationship between inflammation, obesity and cardiovascular disease is currently a subject of much research interest. These specific relationships, however, have not been studied in-depth in South African population groups in order to determine the role of ethnicity. It is known that Africans, compared to Caucasians, suffer from a high prevalence of hypertension. It was therefore hypothesized that the levels of inflammatory markers (high-sensitivity C-reactive protein (hsCRP), fibrinogen and leptin) are higher in Africans compared to Caucasians and are notably associated with cardiovascular dysfunction in Africans. Apparently healthy African (N ¼ 102) and Caucasian (N ¼ 115) women, matched for age and body mass index (BMI), were recruited. Leptin, hsCRP, fibrinogen and lipid levels, waist circumference (WC), BMI, systolic and diastolic blood pressure, cardiac output (CO), total peripheral resistance (TPR) and Windkessel compliance were measured. Results showed that the levels of leptin, hsCRP and fibrinogen were significantly higher (Po0.05) in the African women. The inflammatory markers correlated strongly with cardiovascular parameters, age and obesity (BMI, WC) in both groups, but after adjusting for age and obesity, none of the correlations were significant anymore. Multiple regression analyses (with leptin, hsCRP or fibrinogen as dependent variable) showed that only leptin levels of African women were explained by cardiovascular parameters (BP, TPR and CO). In conclusion, even though African women had significantly higher leptin, hsCRP, fibrinogen and blood pressure levels than Caucasian women, no cardiovascular parameters explained the variation in the inflammatory markers (except for leptin levels of African women).

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Atherosclerotic Plaque Imaging

et al. 2005

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Coronary artery disease imaging has traditionally been based on luminal angiography, but it has become evident that this tool, although extremely useful in diagnosing obstructive disease, is insufficient to define the presence and extent of atherosclerotic disease in the vessel wall. Progression of coronary artery disease was also initially evaluated using quantitative coronary angiography, and evidence soon accumulated that minor regression or nonprogression of luminal disease was associated with a favorable cardiovascular outcome. In recent years, however, several other techniques have been developed to image atherosclerosis and are emerging as useful tools in preventive cardiovascular medicine. These techniques provide new methods to assess the burden of atherosclerosis, gauge the risk of cardiovascular events, and offer a means to test the efficacy of therapeutic approaches to atherosclerosis. Furthermore, noninvasive coronary angiography can be performed with some of the new imaging modalities, potentially reducing the number of unnecessary invasive tests. This review focuses on techniques such as cardiac computed tomography, carotid artery intima-media thickness, cardiovascular magnetic resonance imaging, and intravascular ultrasonography as emerging tools in cardiovascular disease prevention.

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In vivo magnetic resonance evaluation of associations between aortic atherosclerosis and both risk factors and coronary artery disease in patients referred for coronary angiography

Cited by 68 publications

References 31 publications

Associations Between Plasma C-reactive Protein Levels and the Severities of Coronary and Aortic Atherosclerosis

Associations Between Plasma C-reactive Protein Levels and the Severities of Coronary and Aortic Atherosclerosis

Inflammation, obesity and cardiovascular function in African and Caucasian women from South Africa: the POWIRS study

Atherosclerotic Plaque Imaging

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