In-vivo Lens Biometry Using the Novel Ultrasound Biomicroscopy

Abstract

Background and AimTo assess the reproducibility of the novel ultrasound biomicroscopy, Insight 100 and its agreement with a swept-source optical coherence tomography, CASIA2.MethodsA total of 96 volunteers (96 eyes) were enrolled. The radius of anterior lens curvature (RAL), the radius of posterior lens curvature (RPL), lens thickness (LT), and lens diameter (LD) were measured with Insight 100 and CASIA2. A semiautomated software was used to adjust the measurement of LT (LTS) and LD (LDS) by Insight 100. Intraobserver and interobserver reproducibility of Insight 100 measurements, and the agreement of results from Insight 100 and CASIA2 were assessed with 95% limit of agreement (LoA), intraclass correlation coefficient (ICC), Pearson correlation, and linear regression.ResultsFor Insight 100 measurements, the intraobserver ICCs of RAL, RPL, LTS, and LDS measurement were 0.996, 0.973, 0.936, and 0.889, and the interobserver ICCs were 0.987, 0.890, 0.974, and 0.816, respectively. There was an excellent correlation in LT measurements (R = 0.961, P < 0.001) but poor agreements in other parameters between the two devices. The LD measurements tended to be larger (95% CI: 0.768–0.928) in CASIA2 when compared with Insight 100.ConclusionInsight 100 could obtain highly repeatable lens biometry in vivo. With better signal penetration, it shows promising potential in future clinical applications.

The relationships between lens diameter and ocular biometric parameters: an ultrasound biomicroscopy-based study

“…And since the lens shape was dependent on the accommodation force, the extracted lens without any accommodation was not comparable to the lens in vivo (17). Compared with previous studies based on cadaver eyes, our study avoided the postmortem changes of cadaver lens from its physiological shape, rendering our findings more precise and compelling (12,13). Besides, the primitive methods of measurement may lack accuracy, and the sample sizes of both studies was relatively small.…”

“…As evidenced by recent studies, measurements of lens diameters with Insight 100 were notably shorter compared to those obtained using OCT. This disparity suggests that the enhanced accuracy offered by Insight 100 could carry considerable implications in guiding more informed surgical decisions ( 12 , 13 ). Besides, compared with conventional UBM, the newly developed Insight 100 exhibits superior signal penetration and reduced invasiveness using a disposable eyepiece, indicating the potential for broader applications ( 11–13 ).…”

“…As evidenced by recent studies, measurements of lens diameters with Insight 100 were notably shorter compared to those obtained using OCT. This disparity suggests that the enhanced accuracy offered by Insight 100 could carry considerable implications in guiding more informed surgical decisions (12,13).…”

“…Here we introduced a newly developed very high frequency (VHF) ultrasound biomicroscopy (UBM), ArcScan Insight 100. Compared with conventional UBM, it offers superior signal penetration and better ability to capture the entire anterior segment in a single image, and is less invasive by using a disposable eyepiece, which allows to measure the LD more accurately and conveniently (11)(12)(13).…”

Exploring Nomograms for Implantable Collamer Lens Size Selection in Myopia: A Literature-based Compilation

“…Three clear images from OCT and UBM including one image from a very high frequency UBM called ArcScan Insight ® 100 (ArcScan Inc., Golden, CO, USA) were selected that depict the anterior and posterior chamber structures ( Figures 2 and 3 ). 19 , 20 Images with excessive labelling or zoom were excluded. Images selected were from open-access articles that allowed modification of images.…”