In vivo intravascular photoacoustic imaging of plaque lipid in coronary atherosclerosis

Iskander-Rizk, Sophinese; Wu, Min; Springeling, Geert; Beusekom, Heleen M.M. van; Mastik, Frits; Hekkert, Maaike te Lintel; Beurskens, Robert; Hoogendoorn, Ayla; Hartman, Eline M J; Steen, Antonius F.W. van der; Wentzel, Jolanda J.; Soest, Gijs van

doi:10.4244/eij-d-19-00318

Cited by 17 publications

(15 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A study in an atherosclerotic animal model is ongoing. 33 Can the assessment of local haemodynamic forces improve the identification of vulnerable plaques and patients?…”

Section: Imaging Of the High-risk/culprit Coronary Plaquementioning

confidence: 99%

Vulnerable plaques and patients: state-of-the-art

Tomaniak

Katagiri

Modolo

et al. 2020

European Heart Journal

Self Cite

120

View full text Add to dashboard Cite

Despite advanced understanding of the biology of atherosclerosis, coronary heart disease remains the leading cause of death worldwide. Progress has been challenging as half of the individuals who suffer sudden cardiac death do not experience premonitory symptoms. Furthermore, it is well-recognized that also a plaque that does not cause a haemodynamically significant stenosis can trigger a sudden cardiac event, yet the majority of ruptured or eroded plaques remain clinically silent. In the past 30 years since the term ‘vulnerable plaque’ was introduced, there have been major advances in the understanding of plaque pathogenesis and pathophysiology, shifting from pursuing features of ‘vulnerability’ of a specific lesion to the more comprehensive goal of identifying patient ‘cardiovascular vulnerability’. It has been also recognized that aside a thin-capped, lipid-rich plaque associated with plaque rupture, acute coronary syndromes (ACS) are also caused by plaque erosion underlying between 25% and 60% of ACS nowadays, by calcified nodule or by functional coronary alterations. While there have been advances in preventive strategies and in pharmacotherapy, with improved agents to reduce cholesterol, thrombosis, and inflammation, events continue to occur in patients receiving optimal medical treatment. Although at present the positive predictive value of imaging precursors of the culprit plaques remains too low for clinical relevance, improving coronary plaque imaging may be instrumental in guiding pharmacotherapy intensity and could facilitate optimal allocation of novel, more aggressive, and costly treatment strategies. Recent technical and diagnostic advances justify continuation of interdisciplinary research efforts to improve cardiovascular prognosis by both systemic and ‘local’ diagnostics and therapies. The present state-of-the-art document aims to present and critically appraise the latest evidence, developments, and future perspectives in detection, prevention, and treatment of ‘high-risk’ plaques occurring in ‘vulnerable’ patients.

show abstract

“…A study in an atherosclerotic animal model is ongoing. 33 Can the assessment of local haemodynamic forces improve the identification of vulnerable plaques and patients?…”

Section: Imaging Of the High-risk/culprit Coronary Plaquementioning

confidence: 99%

Vulnerable plaques and patients: state-of-the-art

Tomaniak

Katagiri

Modolo

et al. 2020

European Heart Journal

Self Cite

120

View full text Add to dashboard Cite

show abstract

“…In contrast to these transabdominal imaging approaches described above, several studies have also utilized catheter-based approaches ex vivo [ 47 , 53 , 54 ], in animal models [ 48 , 55 ] or human samples [ 49 , 50 ], with laser illumination around 930 nm for detecting the peak absorption of lipids in the first NIR window ( Figure 1 ). Other studies aimed to increase the specificity of OAI for identification of carotid atherosclerosis by targeted approaches.…”

Section: Optoacoustic Imaging Of Inflammation: Applicationsmentioning

confidence: 99%

Optoacoustic Imaging in Inflammation

et al. 2021

View full text Add to dashboard Cite

Optoacoustic or photoacoustic imaging (OAI/PAI) is a technology which enables non-invasive visualization of laser-illuminated tissue by the detection of acoustic signals. The combination of “light in” and “sound out” offers unprecedented scalability with a high penetration depth and resolution. The wide range of biomedical applications makes this technology a versatile tool for preclinical and clinical research. Particularly when imaging inflammation, the technology offers advantages over current clinical methods to diagnose, stage, and monitor physiological and pathophysiological processes. This review discusses the clinical perspective of using OAI in the context of imaging inflammation as well as in current and emerging translational applications.

show abstract

“…Recently, Iskandder-Risk et al demonstrated IVPA in vivo imaging of swine coronary artery. The quality of images were adjudicated using OCT and histology ( 79 ).…”

Section: Photoacoustic Imagingmentioning

confidence: 99%

Intravascular Molecular Imaging: Near-Infrared Fluorescence as a New Frontier

Khraishah

Jaffer

2020

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

Despite exciting advances in structural intravascular imaging [intravascular ultrasound (IVUS) and optical coherence tomography (OCT)] that have enabled partial assessment of atheroma burden and high-risk features associated with acute coronary syndromes, structural-based imaging modalities alone do not comprehensively phenotype the complex pathobiology of atherosclerosis. Near-infrared fluorescence (NIRF) is an emerging molecular intravascular imaging modality that allows for in vivo visualization of pathobiological and cellular processes at atheroma plaque level, including inflammation, oxidative stress, and abnormal endothelial permeability. Established intravascular NIRF imaging targets include macrophages, cathepsin protease activity, oxidized low-density lipoprotein and abnormal endothelial permeability. Structural and molecular intravascular imaging provide complementary information about plaque microstructure and biology. For this reason, integrated hybrid catheters that combine NIRF-IVUS or NIRF-OCT have been developed to allow co-registration of morphological and molecular processes with a single pullback, as performed for standalone IVUS or OCT. NIRF imaging is approaching application in clinical practice. This will be accelerated by the use of FDA-approved indocyanine green (ICG), which illuminates lipid- and macrophage-rich zones of permeable atheroma. The ability to comprehensively phenotype coronary pathobiology in patients will enable a deeper understanding of plaque pathobiology, improve local and patient-based risk prediction, and usher in a new era of personalized therapy.

show abstract

In vivo intravascular photoacoustic imaging of plaque lipid in coronary atherosclerosis

Cited by 17 publications

References 5 publications

Vulnerable plaques and patients: state-of-the-art

Vulnerable plaques and patients: state-of-the-art

Optoacoustic Imaging in Inflammation

Intravascular Molecular Imaging: Near-Infrared Fluorescence as a New Frontier

Contact Info

Product

Resources

About