In Vivo Imaging, Tracking, and Targeting of Cancer Stem Cells

Abstract

Our results demonstrate that reduced 26S proteasome activity is a general feature of CICs that can easily be exploited to identify, track, and target them in vitro and in vivo.

Application of Stem Cells in Targeted Therapy of Breast Cancer: A Systematic Review

“…Nine out of 32 studies, with heterogeneous study design, met the predefined inclusion criteria and all were reviewed Of these, six studies were phase I (Dwyer et al, 2007;Woodward et al, 2007;Vlashi et al, 2009;Grisendi et al, 2010;Dwyer et al, 2011;Milane et al, 2011)and three were phase II clinical trials (Table 1) (Ueno et al, 2009;Resetkova et al, 2010;Viens et al, 2010). There was no published paper regarding phase III clinical trial on stem cell targeted therapy of breast cancer within the period of this study.…”

“…Therefore reduced 26S proteasome activity couldbe applied for identification, tracking, and targeting of this subpopulation (Vlashi et al, 2009).…”

“…In the second group of studies, cancer stem cells were targeted via their characteristics such as markers or signaling pathways. In a study by Vlashi et al (2009) the 26S proteasome as the main regulator of many processes within a proliferating cell has been applied for imaging, tracking and targeting of CSCs. Reduced proteasome activity may occur simultaneously with the expression of stem cell markers and lack of differentiation markers (Vlashi et al, 2009).…”

“…In a study by Vlashi et al (2009) the 26S proteasome as the main regulator of many processes within a proliferating cell has been applied for imaging, tracking and targeting of CSCs. Reduced proteasome activity may occur simultaneously with the expression of stem cell markers and lack of differentiation markers (Vlashi et al, 2009). CSCs may be either immunologically silent or express antigens leading to failure in current targeted immunotherapy approaches.…”

Extracellular ATP reduces tumor sphere growth and cancer stem cell population in glioblastoma cells

“…The concept of cancer stem cells (CSCs) brought a change of paradigm in cancer biology and therapeutics [2,3], suggesting that specifically targeting these cells for destruction [4] or differentiation [5] may be the best therapeutic strategy to follow for several aggressive types of cancers. This, however, may not be easy, since CSCs have shown to present less reactive oxygen species [6] and to be more resistant to ionizing radiation [7], vincristine [8], hypoxia, and other chemotherapeutics [9] when compared to nonCSCs.…”