In vivo imaging of insulin receptors by PET: preclinical evaluation of iodine-125 and iodine-124 labelled human insulin

Iozzo, Patricia; Osman, Safiye; Glaser, Matthias; Knickmeier, Markus; Ferrannini, Ele; Pike, Victor W.; Camici, Paolo G.; Law, Marilyn P.

doi:10.1016/s0969-8051(01)00286-4

Cited by 34 publications

(27 citation statements)

References 36 publications

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“…By using dynamic 18 F-FDG PET, Iozzo et al were the first to show that physiologic hyperinsulinemia enhances hepatic glucose uptake in humans and pigs (34); in agreement with these findings, the authors visualized insulin receptors in the rat liver using 124 I-labeled human insulin and PET (35). They also demonstrated an inverse relationship between hepatic glucose uptake and liver fat content (36).…”

Section: Hepatic Metabolism Studied By Petmentioning

confidence: 87%

Bringing Physiology into PET of the Liver

Keiding¹

2012

J Nucl Med

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Several physiologic features make interpretation of PET studies of liver physiology an exciting challenge. As with other organs, hepatic tracer kinetics using PET is quantified by dynamic recording of the liver after the administration of a radioactive tracer, with measurements of time–activity curves in the blood supply. However, the liver receives blood from both the portal vein and the hepatic artery, with the peak of the portal vein time–activity curve being delayed and dispersed compared with that of the hepatic artery. The use of a flow-weighted dual-input time–activity curve is of importance for the estimation of hepatic blood perfusion through initial dynamic PET recording. The portal vein is inaccessible in humans, and methods of estimating the dual-input time–activity curve without portal vein measurements are being developed. Such methods are used to estimate regional hepatic blood perfusion, for example, by means of the initial part of a dynamic 18F-FDG PET/CT recording. Later, steady-state hepatic metabolism can be assessed using only the arterial input, provided that neither the tracer nor its metabolites are irreversibly trapped in the prehepatic splanchnic area within the acquisition period. This is used in studies of regulation of hepatic metabolism of, for example, 18F-FDG and 11C-palmitate.

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Section: Hepatic Metabolism Studied By Petmentioning

confidence: 87%

Bringing Physiology into PET of the Liver

Keiding¹

2012

J Nucl Med

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“…Although the radiolabelling method in PET is considerably more elaborated, some drugs have been used for PET studies as aerosols, including: 11 C-triamcinolone (Berridge et al, 2000a), 11 C-formoterol (Visser et al, 1998), 18 Finsulin (Guenther et al, 2006), 124 I-insulin, and 125 I-insulin (Iozzo et al, 2002). Alternatively, the lung physiology can be studied by using aerosols of 18 F-Fluorodeoxyglucose (FDG -Dolovich, 2009).…”

Section: Positron Emission Tomography (Pet)mentioning

confidence: 99%

Influence of particle size on regional lung deposition – What evidence is there?

Carvalho

Peters

Williams

2011

International Journal of Pharmaceutics

465

268

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“…Iozzo et al [30] prepared 124 I-labeled human insulin by direct electrophilic iodination at the A14-tyrosine residue. It retains receptor binding properties and biological activity as the native hormone.…”

Section: Clinical Applications Of 124imentioning

confidence: 99%

¹²⁴Iodine: A Longer-Life Positron Emitter Isotope—New Opportunities in Molecular Imaging

Cascini

Asabella

Notaristefano

et al. 2014

BioMed Research International

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124Iodine (124I) with its 4.2 d half-life is particularly attractive for in vivo detection and quantification of longer-term biological and physiological processes; the long half-life of 124I is especially suited for prolonged time in vivo studies of high molecular weight compounds uptake. Numerous small molecules and larger compounds like proteins and antibodies have been successfully labeled with 124I. Advances in radionuclide production allow the effective availability of sufficient quantities of 124I on small biomedical cyclotrons for molecular imaging purposes. Radioiodination chemistry with 124I relies on well-established radioiodine labeling methods, which consists mainly in nucleophilic and electrophilic substitution reactions. The physical characteristics of 124I permit taking advantages of the higher PET image quality. The availability of new molecules that may be targeted with 124I represents one of the more interesting reasons for the attention in nuclear medicine. We aim to discuss all iodine radioisotopes application focusing on 124I, which seems to be the most promising for its half-life, radiation emissions, and stability, allowing several applications in oncological and nononcological fields.

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In vivo imaging of insulin receptors by PET: preclinical evaluation of iodine-125 and iodine-124 labelled human insulin

Cited by 34 publications

References 36 publications

Bringing Physiology into PET of the Liver

Bringing Physiology into PET of the Liver

Influence of particle size on regional lung deposition – What evidence is there?

¹²⁴Iodine: A Longer-Life Positron Emitter Isotope—New Opportunities in Molecular Imaging

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In vivo imaging of insulin receptors by PET: preclinical evaluation of iodine-125 and iodine-124 labelled human insulin

Cited by 34 publications

References 36 publications

Bringing Physiology into PET of the Liver

Bringing Physiology into PET of the Liver

Influence of particle size on regional lung deposition – What evidence is there?

124Iodine: A Longer-Life Positron Emitter Isotope—New Opportunities in Molecular Imaging

Contact Info

Product

Resources

About

¹²⁴Iodine: A Longer-Life Positron Emitter Isotope—New Opportunities in Molecular Imaging