In Vivo Imaging of Abdominal Aortic Aneurysms:<b>Increased FDG Uptake Suggests Inflammation in the Aneurysm Wall</b>

Truijers, Maarten; Kurvers, H. A. J. M.; Bredie, S.J.H.; Oyen, Wim J.G.; Blankensteijn, Jan D.

doi:10.1583/08-2447.1

Cited by 83 publications

(72 citation statements)

References 23 publications

(27 reference statements)

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“…They compared the SUVmax between these two groups. Those with AAA had a significantly higher SUV-max compared to the control group (26). These findings were reproducible and reported by other groups as well (36,37 (23).…”

Section: Clinical Studies Of Fdg-pet Imaging Of Inflammation In Abdomsupporting

confidence: 89%

Role of molecular imaging with positron emission tomographic in aortic aneurysms

et al. 2017

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Aortic aneurysms (AA) are often asymptomatic before the occurrence of acute, potentially fatal complications including dissection and/or rupture. Beyond aortic size, the ability to assess aortic wall characteristics and processes contributing to aneurysm development may allow improved selection of patients who may benefit from prophylactic surgical intervention. Current risk stratification for aneurysms relies upon routine noninvasive imaging of aortic size without assessing the underlying pathophysiologic processes, including features such as inflammation, which may be associated with aneurysm development and progression. The use of molecular imaging modalities with positron emission tomographic (PET) scan allows characterization of aortic wall inflammatory activity. Elevated uptake of Fuorine-2-deoxy-D-glucose (FDG), a radiotracer with elevated avidity in highly-metabolic cells, has been correlated with the development and progression of both abdominal and thoracic AA in a number of animal models and clinical studies. Other novel PET radiotracers targeting matrix metalloproteinases (MMPs), mitochondrial translocator proteins (TSPO) and endothelial cell adhesion molecules are being investigated for clinical utility in identifying progression of disease in AA. By further defining the activation of molecular pathways in assessing aortic regions at risk for dilatation, this imaging modality can be integrated into future clinical decision-making models.

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Section: Clinical Studies Of Fdg-pet Imaging Of Inflammation In Abdomsupporting

confidence: 89%

Role of molecular imaging with positron emission tomographic in aortic aneurysms

et al. 2017

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“…Therefore, functional imaging has been increasingly advocated, lately by the use of 18 F-FDG-PET. [10][11][12][13][14] The sensitivity of imaging techniques for detection and activity assessment in patients with A/CP depends on the stage Owing to the low n-number (n 5 3), treated aortitis patients were not included in the statistical analysis.…”

Section: Discussionmentioning

confidence: 99%

Perfusion-based assessment of disease activity in untreated and treated patients with aortitis and chronic periaortitis: correlation with CT morphological, clinical and serological data

Bier¹,

Henes²,

Eulenbruch³

et al. 2015

BJR

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Objective: To evaluate the role of perfusion-based assessment of inflammatory activity in patients with treated and untreated aortitis and chronic periaortitis as compared with clinical and serological markers. Methods: 35 patients (20 females; median age 66 years) with (peri) aortitis were retrospectively evaluated. All patients had clinical symptoms prompting at the time of imaging. All patients first underwent whole-body contrastenhanced CT and subsequently segmental volume perfusion CT for assessment of the degree of vascularization of (peri) aortitis as a surrogate marker for inflammatory activity. Blood flow, blood volume, volume transfer constant (k-trans), time to peak and mean transit time were determined. The thickness of the increased connective tissue formation was measured. Perfusion data were correlated with clinical symptoms and acute-phase inflammatory parameters such as C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and leukocyte number.Results: 21 of 35 patients were untreated and 14 of 35 had previous/ongoing immunosuppression. The interobserver agreement was good (k 5 0.78) for all perfusion parameters. Average values of perfusion parameters were higher in untreated patients but remained abnormally elevated in treated patients as well. Perfusion data and ESR and CRP correlated well both in aortitis (p , 0.05) and in periaortitis (p , 0.05). In periaortitis, perfusion parameters agreed well with ESR and CRP values (p , 0.05) only in untreated patients. Conclusion: Perfusion CT parameters in untreated aortitis and chronic periaortitis correlate well with serological markers with respect to disease activity assessment. However, in treated periaortitis, correlations were weak, suggesting an increased role for (perfusion-based) imaging. Advances in knowledge: Volume perfusion CT may be used for diagnosis of aortitis/periaortitis.

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“…Therefore, use of 18 F-FDG uptake on 50-minute to stratification patients with AA dissection may be useful for predicting short-term and mid-term prognosis and achieving better management (68). Additionally, many previous studies have shown that FDG in the AA group has higher uptake than that the normal aortic group (63,65,69 F-FDG samples (71). Therefore, 18 F-FDG might be a new pathway to study the mechanical of AA and to predict the risk of rupture.…”

Section: Metabolism Activitiesmentioning

confidence: 99%

“…Growing evidence show that an increase in 18 F-FDG uptake is a latent signal in the aorta with active atherosclerotic inflammation (59,60). Many studies have attempted to use 18 F-FDG to evaluate aortic diseases (61)(62)(63)(64)(65)(66)(67).…”

Section: Metabolism Activitiesmentioning

confidence: 99%

Molecular targets in aortic aneurysm for establishing novel management paradigms

Zhu

et al. 2017

J. Thorac. Dis.

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Aortic aneurysm (AA) is a lethal disease and presents a large challenge for surgeons in the clinic.Although surgical management remains the major choice of AA, operative mortality remains high. With advances in understanding of the mechanisms of AAs, molecular targets, such as matrix metalloproteinases (MMPs), D-dimer, and inflammation markers, including C-reactive protein, interleukins and phagocytes, are important in the pathology of development of AA. These markers may become important for improving the diagnostic quality and provide more therapeutic choices for treatment of AA. Although these new markers require long-term trials before they can be translated into the clinic, they can still be helpful in determining new directions. The main aim of this review is to discuss the current findings of molecular targets in progression of AA and discuss the potential application of these new targets for managing this disease.

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In Vivo Imaging of Abdominal Aortic Aneurysms:Increased FDG Uptake Suggests Inflammation in the Aneurysm Wall

Cited by 83 publications

References 23 publications

Role of molecular imaging with positron emission tomographic in aortic aneurysms

Role of molecular imaging with positron emission tomographic in aortic aneurysms

Perfusion-based assessment of disease activity in untreated and treated patients with aortitis and chronic periaortitis: correlation with CT morphological, clinical and serological data

Molecular targets in aortic aneurysm for establishing novel management paradigms

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