In vivo human time-exposure study of orally dosed commercial silver nanoparticles

Abstract

Background Human biodistribution, bioprocessing and possible toxicity of nanoscale silver receives increasing health assessment. Methods We prospectively studied commercial 10- and 32-ppm nanoscale silver particle solutions in a single-blind, controlled, cross-over, intent-to-treat, design. Healthy subjects (n=60) underwent metabolic, blood counts, urinalysis, sputum induction, and chest and abdomen magnetic resonance imaging. Silver serum and urine content was determined. Results No clinically important changes in metabolic, hematologic, or urinalysis measures were identified. No morphological changes were detected in the lungs, heart or abdominal organs. No significant changes were noted in pulmonary reactive oxygen species or pro-inflammatory cytokine generation. Conclusion In vivo oral exposure to these commercial nanoscale silver particle solutions does not prompt clinically important changes in human metabolic, hematologic, urine, physical findings or imaging morphology. Further study of increasing time exposure and dosing of silver nanoparticulate silver, and observation of additional organ systems is warranted to assert human toxicity thresholds.

The Effect of Silver Nanoparticles on the Biochemical Parameters of Liver Function in Serum, and the Expression of Caspase-3 in the Liver Tissues of Male Rats

“…Given the increased introduction of new nanoscale products in everyday life (19), this experiment was carried out to evaluate the effect of Ag-NPs on biochemical parameters and the expression of caspase-3 in the liver tissues of male rats.…”

Antimicrobial activity of bone cements embedded with organic nanoparticles

“…The use of metals, predominantly silver, in the form of salts or nanoparticles is a well-established antimicrobial strategy that found applications in creams, 3 wound wrappings, 4 fabrics, 5 and eluting surfaces. [6][7][8] However, concerns regarding the use of silver are growing, particularly its long-term safety linked to accumulation in the environment and the body, 9,10 hence other antimicrobial agents are in urgent need. Chitosan, 11 honey extracts, 12 and phytochemicals 13 are natural compounds that have shown promising results.…”

Permeability of skin to silver nanoparticles after epidermal skin barrier disruption in rats

“…Thus, ionization of silver nanoparticles and ability of Ag + ions to penetrate into or across the skin may result in nanotoxicity. Clinical trials have started, but their scope in limited (Bianco et al, 2015b;Munger et al, 2014;Rigo et al, 2013) In conclusion, this study found that 5 nm Ag nanoparticles cannot pass through rat skin, even after disruption of the epidermal barrier. In contrast, Ag + ions were able to penetrate rat skin after epidermal barrier disruption.…”

“…Percutaneous absorption of silver nanoparticles is still a matter of investigation by researchers because of different view (Ahamed et al, 2010;Bianco et al, 2015a;Munger et al, 2014;Samberg et al, 2010;Stefaniak et al, 2014). Thus, accumulation of reliable data of animal study to examine the penetration of nanoparticles under damaged skin condition should be important for risk assessment.…”