In vivo human retinal imaging by Fourier domain optical coherence tomography

Abstract

We present what is to our knowledge the first in vivo tomograms of human retina obtained by Fourier domain optical coherence tomography. We would like to show that this technique might be as powerful as other optical coherence tomography techniques in the ophthalmologic imaging field. The method, experimental setup, data processing, and images are discussed.

Clinical Application of Rapid Serial Fourier-Domain Optical Coherence Tomography for Macular Imaging

“…A state-of-the-art FD OCT system similar to that previously described by Wojtkowski et al 6 and further improved by Nassif et al 7 was used to image the 5 patients. This system was constructed and developed at University of California-Davis in collaboration with Duke University.…”

Optical coherence tomography imaging in uveitis

“…In 2002, a third generation time-domain (TD) OCT 3 (Stratus OCT; Carl Zeiss Meditec) became available with an axial resolution of 10 lm and a scan velocity of 400 axial scans/sec. Since 2004, higher resolution spectral-domain OCT (SD OCT) has entered clinical practice with reported resolutions of 3-5 lm as well as improved visualization of retinal morphologic and pathologic features [7][8][9][10][11][12][13][14]. SD OCT is the current gold standard for posterior segment retinal tomography.…”

“…It may use either a superluminescent diode or femtosecond titaniumsapphire laser as a light source. In contrast to TD OCT, the reference mirror for SD OCT remains stationary, and the depth information is acquired by analyzing the interference patterns in a spectrum of mixed reflected lights [7][8][9][10][11][12][13][14]. SD OCT technology uses low-coherence interferometry to detect light echoes, relying on a spectrometer and high-speed camera and based on the mathematical premise of Fourier transformation.…”

Extended scan depth optical coherence tomography for evaluating ocular surface shape

“…Both SD-OCT and SS-OCT have been widely applied in the ophthalmic imaging of the posterior and anterior segments. 6,16,17,19,20 Compared with SS-OCT, SD-OCT has the advantage of higher resolution and increased phase stability for functional imaging. 23 Despite rapid advances in SD-OCT, the limited imaging range due to finite resolution of spectrometer remains a major drawback.…”

“…13 It can be used to capture a cross sectional or three dimensional volume images. 6,[14][15][16][17][18][19][20] Compared with conventional time domain OCT, Fourier domain OCT (FD-OCT) offers significant advantages in imaging speed and sensitivity. 21,22 There are two primary types of FD-OCT implementations, depending on the light source and detector configuration.…”