In vivo hepatoprotective activity and the underlying mechanism of chebulinic acid from Terminalia chebula fruit

Feng, Xin-Hong; Xu, Haiyan; Wang, Jian‐Ye; Duan, Shen; Wang, Yingchun; Ma, Cui

doi:10.1016/j.phymed.2021.153479

Cited by 21 publications

(10 citation statements)

References 25 publications

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“…Ojeaburu and Oriakhi (45) demonstrated that Gallic acid lowered the level of serum markers (AST/ALT) and also decreased the levels of malondialdehyde (MDA) that were raised in rats treated with CCl 4 . Chebulinic acid signi cantly reduced the toxicity of CCl 4 , as the application of chebulinic acid decreased the level of MDA in male ICR mice (46). In the animals of group II, the protein and reduced glutathione content were also found to be reduced.…”

Section: Discussionmentioning

confidence: 92%

Amelioration of oxidative stress by trans-Anethole via modulating phase I and phase II enzymes against hepatic damage induced by CCl4 in male Wistar rats

Pandit

Kumar

Kaur

et al. 2021

Environ Sci Pollut Res

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The current study was designed to assess the in vivo hepatoprotective properties of trans-Anethole and it is a principal aromatic component of star anise possessed several therapeutic properties. Results showed that CCl 4 treatment elevated the levels of different serum markers like serum glutamate oxaloacetate transaminase (SGOT) by 4.74 fold, serum glutamate pyruvate transaminase (SGPT) by 3.47 fold, aspartate alkaline phosphatase (ALP) by 3.55 fold, direct bilirubin by 3.48 fold and total bilirubin by 2.38 fold in contrast with control. It was observed that decreased levels of various liver antioxidant enzymes viz. CAT, GR, and GSH were signi cantly ameliorated by the pre-administration of rats with different doses (40, 80, and 160 mg kg -1 bw) of trans-Anethole. Furthermore, pre-treatment of trans-Anethole reduced phase I enzymes level, whereas elevated level of phase II detoxifying enzymes. Furthermore, histopathological examination showed that the treatment with trans-Anethole was potent in defending the liver from CCl 4 toxic injury and restored normal hepatic architecture. Also, trans-Anethole regulated p53 and Cyclin D1 expressions in liver tissue relative to group II treated with CCl 4 . Collectively, the ndings of the study showed a strong e ciency of trans-Anethole in ameliorating the effects caused by CCl 4 through modulation of antioxidants and xenobiotic-metabolizing enzymes.

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Section: Discussionmentioning

confidence: 92%

Amelioration of oxidative stress by trans-Anethole via modulating phase I and phase II enzymes against hepatic damage induced by CCl4 in male Wistar rats

Pandit

Kumar

Kaur

et al. 2021

Environ Sci Pollut Res

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“…Nuclear-factor erythroid 2-related factor 2 (Nrf2), known as the "main regulator" of antioxidant response, regulates a series of antioxidant and cytoprotective dependent protein genes by interacting with the antioxidant response element (ARE) sequences of antioxidant and cytoprotective genes (Kaspar et al, 2009), for example, heme oxygenase-1 (HO-1), quinone oxidoreductase1 (NQO1), glutathione-S-transferase (GST) (Tang et al, 2014). The enhanced activation of Nrf2 by pharmacologic molecules or genetic engineering has been shown to protect the liver in different oxidative stress models (Feng et al, 2021;Lim et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Midazolam Ameliorates Acute Liver Injury Induced by Carbon Tetrachloride via Enhancing Nrf2 Signaling Pathway

et al. 2022

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Oxidative stress contributes greatly to initiation and progression of liver injury. Activation of nuclear-factor erythroid 2-related factor 2 (Nrf2) has been considered as an attractive strategy for preventing and treating the oxidative damage related to liver injury. This study aimed to find an efficacious agent to activate Nrf2/HO-1 signaling pathway from clinically used therapeutic agents and to characterize the usefulness for preventing and treating CCl4-induced acute liver injury. For this purpose, a series of clinically used therapeutic agents were collected and their activation potentials on Nrf2 were assayed by using 293T-Nrf2-luc cell line. Among all tested therapeutic agents, midazolam was found with good Nrf2 activation effect and this agent could significantly ameliorate CCl4-induced damage to HepG2 cells. In vivo animal tests showed that pretreatment with midazolam reduced the liver pathological tissue damage and the serum levels of ALT and AST in CCl4-induced liver injury mice. Further investigations showed that midazolam could strongly up-regulate the expression of both Nrf2 and HO-1 in the mice liver, accompanied by increasing of the levels of antioxidant enzyme SOD and reducing the production of MDA, as well as reducing the pro-inflammatory cytokines (IL-6, TNF-α) secretion. Collectively, our results clearly demonstrate that midazolam can ameliorate CCl4-induced acute liver injury and oxidative stress via activating the Nrf2 signaling pathway.

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“…Considering P. meliocarpoides , all of the different extracts present as the most abundant constituents’ hydrolysable tannins. Nevertheless, chebulic acid (a tricarboxylic acid forming specific ellagitannin derivatives), as well as chebulinic acid (an ellagitannin), were specifically detected only in this species and, to the best of our knowledge, this is the first report of these derivatives in Prangos , while previous identification of such compounds occurred in Terminalia spp and in Phyllantus emblica [ 54 , 55 ]. P. uechtritzii is characterized by the presence of flavonoid glycosides and coumarins, while it contains a negligible amount of condensed or hydrolysable tannin.…”

Section: Resultsmentioning

confidence: 76%

Phytochemical Screening, Antioxidant, and Enzyme Inhibitory Properties of Three Prangos Species (P. heyniae, P. meliocarpoides var. meliocarpoides, and P. uechtritzii) Depicted by Comprehensive LC-MS and Multivariate Data Analysis

et al. 2022

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The aim of the present study was to identify/quantify bioactive compounds and determine the antioxidant activity and enzyme inhibitory effects of various solvent extracts (n-hexane, ethyl acetate, methanol, and water) of Prangos heyniae H. Duman and M.F. Watson, Prangos meliocarpoides var. meliocarpoides, and Prangos uechtritzii Boiss. and Hausskn. This is the first time such a report has been designed to validate the phytochemical composition and bioactivity (especially enzyme inhibitory properties) of these plants. A combined approach of liquid chromatography (LC) with mass spectrometry (HR-MS and MSn) allowed to identify that P. heyniae contains condensed tannins; P. meliocarpoides is rich in hydrolysable tannins; and P. uechtritzii possesses coumarins, flavonoids, and hydroxycinnamic acids. Different extracts were tested for antioxidant activities using a battery of assays, such as 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), ferric reducing antioxidant power (FRAP), cupric reducing antioxidant capacity (CUPRAC), total antioxidant capacity (TAC) (phosphomolybdenum), and metal chelating. Enzyme inhibitory effects were investigated using acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosinase, α-amylase, and α-glucosidase as target enzymes. The obtained results depended on the extraction solvents used for each Prangos species. The methanol extract of P. meliocarpoides var. meliocarpoides exhibited significant radical scavenging activity (DPPH: 52.27 mg Trolox equivalent (TE)/g; ABTS: 92.84 mg TE/g), the most potent-reducing potential (CUPRAC: 154.04 mg TE/g; FRAP: 104.34 mg TE/g), and high TAC (2.52 mmol TE/g). Moreover, the strongest BChE (7.97 mg galantamine equivalent/g), α-amylase (0.46 mmol acarbose equivalent/g), and tyrosinase (81.15 mg kojic acid equivalent/g) inhibitory effects were observed for the hexane extract of P. meliocarpoides var. meliocarpoides. Correlation analysis showed a significant positive correlation between hydrolysable tannins and antioxidant activities. The same trend was also observed between the same class of compounds and the inhibitory effects on enzymatic activities. These results suggest a principal role of hydrolysable tannins in the observed bioactivities of Prangos. Our results suggested that the tested Prangos species could be valuable as sources of natural agents in the development of health-promoting applications.

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In vivo hepatoprotective activity and the underlying mechanism of chebulinic acid from Terminalia chebula fruit

Cited by 21 publications

References 25 publications

Amelioration of oxidative stress by trans-Anethole via modulating phase I and phase II enzymes against hepatic damage induced by CCl4 in male Wistar rats

Amelioration of oxidative stress by trans-Anethole via modulating phase I and phase II enzymes against hepatic damage induced by CCl4 in male Wistar rats

Midazolam Ameliorates Acute Liver Injury Induced by Carbon Tetrachloride via Enhancing Nrf2 Signaling Pathway

Phytochemical Screening, Antioxidant, and Enzyme Inhibitory Properties of Three Prangos Species (P. heyniae, P. meliocarpoides var. meliocarpoides, and P. uechtritzii) Depicted by Comprehensive LC-MS and Multivariate Data Analysis

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