“…Genes involved in the biosynthesis of BCAAs have also been identified as in vivo induced or essential for survival in IVET, microarray and signature-tagged mutagenesis (STM) studies in Neisseria meningitidis (ilvI, ilvD) (Sun et al, 2000), Pseudomonas aeruginosa (ilvA) (Wang et al, 1996), Pasteurella multocida (ilvD, ilvH, ilvM, yjgF) (Fuller et al, 2000;Boyce et al, 2002Boyce et al, , 2004 and Staphylococcus aureus (thrB) (Mei et al, 1997). IlvI mutants of Burkholderia mallei and Burkholderia pseudomallei (Atkins et al, 2002;Ulrich et al, 2005) and leuD mutants of Mycobacterium bovis (McAdam et al, 1995) and Mycobacterium tuberculosis (Bange et al, 1996;Hondalus et al, 2000) are attenuated. Furthermore, inhibitors of BCAA biosynthetic enzymes can prevent the growth of M. tuberculosis in the lungs (Grandoni et al, 1998;Zohar et al, 2003).…”