In vivo functional imaging of the human middle ear with a hand-held optical coherence tomography device

Lui, Christopher; Kim, Wihan; Dewey, James B.; Macías-Escrivá, Frank D.; Ratnayake, Kumara; Oghalai, John S.; Applegate, Brian E.

doi:10.1364/boe.430935

Cited by 28 publications

(19 citation statements)

References 43 publications

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“…The anterior region was thicker than the posterior region as measured with confocal microscopy 13 and optical coherence tomography 12 . Hand‐held OCT device can offer superior ease of use 24 . Low coherence interferometry is another technique used for in vivo measurements of the thickness of the TM.…”

Section: Discussionmentioning

confidence: 99%

“…Computing the thickness of the TM is challenging because of its cone‐shaped structure. The thickness measurements at each voxel on the membrane must be taken orthogonal to the surface of the membrane 24 . From this aspect measurements based on post‐mortem specimens and sectioned TM allow easier thickness measurements.…”

Section: Discussionmentioning

confidence: 99%

“… 12 Hand‐held OCT device can offer superior ease of use. 24 Low coherence interferometry is another technique used for in vivo measurements of the thickness of the TM. Pande et al 25 found that the mean and pooled standard deviation of the thickness of the different regions of the pars tensa of the TM, computed over all TMs, were found to be 137.7 ± 56.1 μm for the posterosuperior quadrant, 93.4 ± 23.9 μm for the posteroinferior quadrant, 76.4 ± 20.5 μm for the anterosuperior quadrant, and 79.2 ± 20.0 μm for the anteroinferior quadrant.…”

Section: Discussionmentioning

confidence: 99%

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Possible clinical implications of the structural variations between the tympanic membrane quadrants

Kassem

Dagan

Biadsee

et al. 2022

Laryngoscope Investig Oto

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Introduction Retraction pockets and marginal perforations of the pars tensa of the tympanic membrane (TM) are most commonly found at superior posterior quadrant (SPQ). The patulous Eustachian tube tends to manifest in the same quadrant. Variation in the structure of the TM may explain these observations. Material and Methods A line defined by the manubrium was used to divide the pars tensa into anterior and posterior portions. A transverse line centered on the umbo divides the pars tensa into superior and inferior parts, resulting in four quadrants. Surface areas of each of the TM quadrants were measured in a sample of 23 human adult formalin‐fixed temporal bones. The TMs were completely excised, faced medially, and placed against graph paper to maintain scale measurements, photoed, and measured. TM thickness was measured on a different set of 20 human temporal bones (TB) preparations with normal external and middle ears. Four random loci were chosen from each pars tensa's TM quadrant. The thickness was measured using high‐magnification power microscopy. Results The SPQ was the largest and thinnest of the four quadrants. It occupies 31% of the pars tensa area. It is 69 μm as compared to approximately 85 μm in the other quadrants. The radial lines between the umbo and the annulus are in descending order from superior posterior toward the anterior‐superior radials. Conclusion The SPQ has the largest vibratory area and is the thinnest of the four TM quadrants. Variation in the thickness of the middle, fibrous layer accounts for the variation in the thickness of the TM. These findings may explain the tendency of pathologies related to Eustachian tube dysfunction to preferentially manifest in or originate from the SPQ. Level of evidence: 5

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Possible clinical implications of the structural variations between the tympanic membrane quadrants

Kassem

Dagan

Biadsee

et al. 2022

Laryngoscope Investig Oto

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“…This flexibility opens up the possibility to image the retina of immobile/bedridden patients or infants, skin areas that are not accessible easily, ear-nose-throat measurements, or even large animals [31] and plants [32] can be imaged. In the last decade, handheld probes have proven their value in imaging the retina [33][34][35][36][37][38][39][40][41][42][43][44][45][46], hair follicles [47] and the tympanic membrane in the ear [30,48,49], to detect and monitor skin cancer [50,51] or skin and mucosal lesions [52][53][54][55][56][57][58], and as an imaging tool to assist in surgery [59,60].…”

Section: Oct Using Handheld Probes and Home/self-octmentioning

confidence: 99%

Miniaturizing optical coherence tomography

Rank

Agneter

Schmoll

et al. 2022

Transl Biophotonics

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Optical coherence tomography (OCT) has revolutionized ophthalmic diagnosis as a non-invasive, cross-sectional imaging technique in the last 30 years and hence is one of the fastest adopted advanced imaging technologies in the history of medicine. A miniaturization of OCT devices would not only reduce size but ideally also reduce costs and therefore create potential new markets. OCT systems based on photonic integrated circuits (PIC) could enable a significant miniaturization of complex systems with high degree of integration as well as low costs of goods. These therefore have a potential to enable portable, cost-effective, high performing, real handheld OCT devices. This review identifies three main categories towards miniaturized OCT devices: Handheld imaging probes interfaced to a (mobile) base station, compact home/self-OCT and PICbased OCT. Imaging performance parameters and technical readiness levels of the identified miniaturized OCT systems for (non-) ophthalmic applications are presented. Special attention is paid to PIC-based OCT applications and their progress.Picture: First in vivo human retinal tomogram using a PIC-based subcomponent (arrayed waveguide grating, AWG) of a spectral domain OCT system.

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“…Here, we showed that noise exposures with intensities sufficient to produce cochlear synaptopathy also result in endolymphatic hydrops which can be detected using OCT. Although the use of OCT for cochlear imaging is currently not performed in humans, an OCT device that images the cochlea through the ear canal may allow translation of this technology to humans (Monroy et al, 2017;Kim et al, 2018b;Kim et al, 2019b;Burwood et al, 2019;Lui et al, 2021).…”

Section: Applications To Acoustic Trauma In Humansmentioning

confidence: 99%

Endolymphatic Hydrops is a Marker of Synaptopathy Following Traumatic Noise Exposure

Badash

Quinones

Oghalai

et al. 2021

Front. Cell Dev. Biol.

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After acoustic trauma, there can be loss of synaptic connections between inner hair cells and auditory neurons in the cochlea, which may lead to hearing abnormalities including speech-in-noise difficulties, tinnitus, and hyperacusis. We have previously studied mice with blast-induced cochlear synaptopathy and found that they also developed a build-up of endolymph, termed endolymphatic hydrops. In this study, we used optical coherence tomography to measure endolymph volume in live CBA/CaJ mice exposed to various noise intensities. We quantified the number of synaptic ribbons and postsynaptic densities under the inner hair cells 1 week after noise exposure to determine if they correlated with acute changes in endolymph volume measured in the hours after the noise exposure. After 2 h of noise at an intensity of 95 dB SPL or below, both endolymph volume and synaptic counts remained normal. After exposure to 2 h of 100 dB SPL noise, mice developed endolymphatic hydrops and had reduced synaptic counts in the basal and middle regions of the cochlea. Furthermore, round-window application of hypertonic saline reduced the degree of endolymphatic hydrops that developed after 100 dB SPL noise exposure and partially prevented the reduction in synaptic counts in the cochlear base. Taken together, these results indicate that endolymphatic hydrops correlates with noise-induced cochlear synaptopathy, suggesting that these two pathologic findings have a common mechanistic basis.

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In vivo functional imaging of the human middle ear with a hand-held optical coherence tomography device

Cited by 28 publications

References 43 publications

Possible clinical implications of the structural variations between the tympanic membrane quadrants

Possible clinical implications of the structural variations between the tympanic membrane quadrants

Miniaturizing optical coherence tomography

Endolymphatic Hydrops is a Marker of Synaptopathy Following Traumatic Noise Exposure

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