In vivo fluorescence navigation of gastric and upper gastrointestinal tumors by 5-aminolevulinic acid mediated photodynamic diagnosis with a laser-equipped video image endoscope

Isomoto, Hajime; Nanashima, Atsushi; Senoo, Takemasa; Ogiwara, Kumi; Hashisako, Mikiko; Ohnita, Ken; Yamaguchi, Naoyuki; Kitajima, Masaki; Hidaka, Shigekazu; Fukuda, Hiroko; Ishii, Hiroyuki; Matsushima, Kayoko; Minami, Hitomi; Akazawa, Yuko; Takeshima, Fuminao; Fukuoka, Junya; Nagayasu, Takeshi

doi:10.1016/j.pdpdt.2015.03.006

Cited by 21 publications

(21 citation statements)

References 24 publications

(51 reference statements)

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“…Early gastric cancer (EGC) detection is not completely satisfactory in the vast gastric cavity . We studied the feasibility of laser‐based photodynamic endoscopic diagnosis (LPDED) using a prototype endoscope (SieP1; Fujifilm Co., Tokyo, Japan) . Five‐aminolevulinic acid (5‐ALA) is metabolized into protoporphyrin IX (Pp IX), which tends to accumulate in tumor cells.…”

Section: Brief Explanationmentioning

confidence: 99%

“…We were able to achieve LPDED as well as conventional observation by instant switching upon pushing a button (Figs ). This all‐in‐one endoscope equipped with both modes, integrated with laser light source, however, should be modified with a band pass filter designed to cut off the blue light . This would limit the drawback of dark images and would enable its general application.…”

Section: Brief Explanationmentioning

confidence: 99%

“…We present the modified LPDED for EGC in a 74‐year‐old man. As described previously, the patient was given 5‐ALA orally and, after 3 h, LPDED was conducted on the day of ESD. A IIa‐type lesion was identified and demarcated with pink fluorescence accompanied by non‐tumor bluish purple background mucosa.…”

Section: Brief Explanationmentioning

confidence: 99%

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Modified laser‐based photodynamic endoscopic diagnosis for early gastric cancer

Sakaguchi

Kinoshita

Isomoto

2019

Digestive Endoscopy

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Section: Brief Explanationmentioning

confidence: 99%

Section: Brief Explanationmentioning

confidence: 99%

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Modified laser‐based photodynamic endoscopic diagnosis for early gastric cancer

Sakaguchi

Kinoshita

Isomoto

2019

Digestive Endoscopy

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“…A Japanese study showed that laser-based endoscopy detected upper GI tumors as red fluorescent navigation (PDD-positive) in 23 of 27 lesions [37]. Interestingly, all but one of the intestinal type carcinomas were significantly PDD-positive, whereas signet ring cell carcinomas were PDD-negative.…”

Section: Gastric Cancermentioning

confidence: 99%

Application of photodynamic therapy in gastrointestinal disorders: an outdated or re-emerging technique?

Lee

Choi

Hasan

2017

Korean J Intern Med

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Photodynamic therapy (PDT) is a promising therapeutic modality that involves the administration of a photosensitizer followed by local illumination with a specific wavelength of light in the presence of oxygen. PDT is minimally invasive, has high selectivity for cancer, and has good patient compliance due to the simplicity of the procedure; therefore, PDT is widely used as a palliative and salvage treatment in patients with various gastrointestinal malignancies. When used as a salvage treatment for locoregional failures after definitive chemoradiotherapy for esophageal cancer, favorable results have been reported. PDT in conjunction with biliary stenting is a promising palliative treatment for unresectable cholangiocarcinoma, and can be used as an advanced diagnostic and therapeutic strategy in peritoneal dissemination of gastric cancer. Recent clinical reports of PDT for treating non-resectable pancreatic cancer also show promising results. To widen the application of PDT, the integration of PDT with molecular imaging and nanotechnology is being extensively studied. Based on these new developments, PDT is likely to re-emerge as a valuable technique in the treatment of diverse gastrointestinal diseases.

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“…Em neoplasias gástricas, utiliza-se um endoscópio que possua um laser acoplado, permitindo assim, a diferenciação de lesões malignas e benignas por meio de uma endoscopia simples e pouco invasiva (ISOMOTO et al, 2015;KISHI et al, 2014;NAKAMURA & OINUMA, 2014;NAMIKAWA et al, 2015).…”

Section: Oncologiaunclassified

Diagnóstico Fotodinâmico: Princípios E Aplicações

Oliveira¹,

Teles²,

Bezerra³

et al. 2015

Enciclopédia Biosfera

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RESUMONos últimos anos, houve um crescimento na utilização de técnicas baseadas em fluorescência. Entretanto, na Medicina Veterinária tais técnicas são pouco difundidas e utilizadas. Diante da necessidade de um maior esclarecimento na utilização dessas técnicas para auxiliar o diagnóstico de enfermidades, o objetivo principal deste trabalho foi englobar as principais aplicações do fotodiagnóstico, bem como os fotossensibilizadores mais utilizados neste processo. O diagnóstico fotodinâmico baseia-se na forma em que tecidos normais e anormais absorvem a luz, permitindo então a visualização de fluorescência diferencial nestes tecidos quando em contato com fluoróforos. Estes fluoróforos podem ser endógenos ou exógenos, e emitem fluorescência ao serem excitados por um comprimento de onda específico da luz visível dentro da gama do espectro. Os fluoróforos exógenos são chamados de fotossensibilizadores e possuem um papel fundamental no fotodiagnóstico, pois são moléculas capazes de interagir com luz e gerar fluorescência ou espécies reativas do oxigênio. Esta técnica pode ser aplicada para o diagnóstico de diversas enfermidades, como, por exemplo, no diagnóstico de fungos de pele, na detecção da cárie dentária, cálculos e biofilmes bacterianos, na detecção de pequenas lesões no trato digestório e principalmente no diagnóstico precoce do câncer e no tratamento de neoplasias. Por ser uma técnica inovadora, que apresenta uma alta sensibilidade e especificidade, não ser invasiva, além de ser uma técnica rápida e de fácil realização, o diagnóstico fotodinâmico apresenta um enorme potencial de utilização na Medicina Veterinária.

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In vivo fluorescence navigation of gastric and upper gastrointestinal tumors by 5-aminolevulinic acid mediated photodynamic diagnosis with a laser-equipped video image endoscope

Cited by 21 publications

References 24 publications

Modified laser‐based photodynamic endoscopic diagnosis for early gastric cancer

Modified laser‐based photodynamic endoscopic diagnosis for early gastric cancer

Application of photodynamic therapy in gastrointestinal disorders: an outdated or re-emerging technique?

Diagnóstico Fotodinâmico: Princípios E Aplicações

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