In Vivo Fluorescence Imaging with Ag<sub>2</sub>S Quantum Dots in the Second Near‐Infrared Region

Hong, Guosong; Robinson, Joshua T.; Zhang, Yejun; Diao, Shuo; Antaris, Alexander L.; Wang, Qiangbin; Dai, Hongjie

doi:10.1002/anie.201206059

Cited by 663 publications

(528 citation statements)

References 34 publications

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“…In vivo NIR imaging was achieved over a period of 24 h. The fluorescence emission that lies in the first near-infrared window (NIR-I; 650-900 nm) is far superior to visible wavelengths, but a fluorophore that emits within the second nearinfrared window (NIR-II; 1000-1700 nm) exhibits a greater improvement in imaging quality, such as decreased tissue autofluorescence, reduced photon scattering, and low levels of photon absorption. [63][64][65][66] However, NIR-II fluorophores are often constrained by slow metabolism and long retention in the reticuloendothelial system. Hong et al synthesized a soluble NIR-II emitting probe (5) for imaging the mouse lymphatic vasculature and sentinel lymphatic mapping near the tumor.…”

Section: Nir Imaging Fluorophoresmentioning

confidence: 99%

Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy

et al. 2017

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Surgical resection of solid tumors is currently the gold standard and preferred therapeutic strategy for cancer. Chemotherapy drugs also make a significant contribution by inhibiting the rapid growth of tumor cells and these two approaches are often combined to enhance treatment efficacy. However, surgery and chemotherapy inevitably lead to severe side effects and high systemic toxicity, which in turn results in poor prognosis. Precision medicine has promoted the development of treatment modalities that are developed to specifically target and kill tumor cells. Advances in in vivo medical imaging for visualizing tumor lesions can aid diagnosis, facilitate surgical resection, investigate therapeutic efficacy, and improve prognosis. In particular, the modality of fluorescence imaging has high specificity and sensitivity and has been utilized for medical imaging. Therefore, there are great opportunities for chemists and physicians to conceive, synthesize, and exploit new chemical probes that can image tumors and release chemotherapy drugs in vivo. This review focuses on small molecular ligand-targeted fluorescent imaging probes and fluorescent theranostics, including their design strategies and applications in clinical tumor treatment. The progress in chemical probes described here suggests that fluorescence imaging is a vital and rapidly developing field for interventional surgical imaging, as well as tumor diagnosis and therapy.

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Section: Nir Imaging Fluorophoresmentioning

confidence: 99%

Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy

et al. 2017

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“…17 In particular, the applicability in the second biological window (II-BW) opens up the possibility of not only deep tissue imaging but also of high contrast, autofluorescence free in vivo fluorescence thermal sensing, as it has already been demonstrated in imaging applications. [18][19][20][21][22][23][24][25] As an additional requirement, the multifunctional NPs to be used should operate under infrared radiation single beam excitation at wavelength avoiding any non-selective cellular damage. Recent studies dealing with the heating effects and the light-induced cytotoxicity during in vitro imaging experiments have pointed out 808 nm as an optimal excitation wavelength, since it simultaneously minimizes both the laser-induced thermal loading of the tissue and the intracellular photochemical damage.…”

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confidence: 99%

LaF3 core/shell nanoparticles for subcutaneous heating and thermal sensing in the second biological-window

Ximendes

Rocha

Kumar

et al. 2016

Applied Physics Letters

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We report on Ytterbium and Neodymium codoped LaF 3 core/shell nanoparticles capable of simultaneous heating and thermal sensing under single beam infrared laser excitation. Efficient light-to-heat conversion is produced at the Neodymium highly doped shell due to non-radiative deexcitations. Thermal sensing is provided by the temperature dependent Nd 3þ ! Yb 3þ energy transfer processes taking place at the core/shell interface. The potential application of these core/shell multifunctional nanoparticles for controlled photothermal subcutaneous treatments is also demonstrated. Published by AIP Publishing. [http://dx.doi.org/10.1063/1.4954170] Photothermal therapy (PTT) is a therapeutic strategy in which photon energy is converted into heat to cause irreversible damage at the cellular level and that could efficiently treat a great variety of diseases including cancer tumors. [1][2][3] In particular, nanoparticle (NP) based PTTs are attracting great attention nowadays. They are based on the use of nanoheaters (NHs), which are NPs with large light-to-heat conversion efficiencies. [4][5][6] The selective incorporation of NHs into cancer cells or tumors provides the means by which a subsequent optical excitation produces a temperature increment that will only affect the tissues aimed to be treated. The net effects caused on cancer tumors during PTTs strongly depend on both the magnitude of the heating as well as the treatment duration. [7][8][9][10] In this regard, in order to achieve an efficient treatment and keep the collateral damage at minimum it is extremely necessary to have a temperature reading during NP based PTTs. As a consequence, there has been an increasing interest in the design of multifunctional luminescent NPs capable of simultaneous heating and thermal sensing under single power excitation as they would constitute significant building blocks toward the achievement of real controlled PTTs as well as subcutaneous studies. 11 Despite the continuously growing list of systems that could operate as simultaneous NHs and nanothermometers (NThs), including polymeric NPs, quantum dots, nanodiamonds, metallic NPs, and rare earth-doped NPs, only a few of them show real potential of working subcutaneously. 12-14 This is so because most of them operate in the visible spectrum domain, where optical penetration into tissues is minimal. To avoid this limitation, it is necessary to shift their operation spectral range from the visible to the spectral infrared ranges where tissues become partially transparent (due to simultaneous attenuation in both tissue absorption and scattering), lying in the so-called biological windows (BWs). 15,16 Traditionally, three biological windows are defined: the first extending from 650 up to 950 nm, the second covering the infrared region about 1000-1350 nm and the third extending from 1500 up to 1750 nm. 17 In particular, the applicability in the second biological window (II-BW) opens up the possibility of not only deep tissue imaging but also of high contrast, autofluorescence free in ...

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“…Materials : NMP, Na 2 CO 3 , NaH 2 PO 4 , Na 2 HPO 4 , NaCl, KCl, AgNO 3 O were purchased from Sinopharm Chemical Reagent Co., Ltd (China). MitoTracker Red, LysoTracker Green, and rhodamine 6G were purchased from Molecular Probes (Life Technologies, USA).…”

Section: Methodsmentioning

confidence: 99%

“…[1][2][3] Thus far, various materials-including organic dyes, fl uorescent proteins and fl uorescent semiconductor nanocrystals-have been such as exerting the fl uorescence effi ciency, increasing water solubility and biocompatibility, increasing surface passivation or modifi cation with macromolecules. [ 9,18 ] In addition, the carbon dots (CDs) prepared by previous methods have seldom been exploited for imaging cancer in vitro and in vivo, especially not for the targeting imaging of glioma due to biological barriers such as the blood-brain barrier (BBB).…”

Section: Introductionmentioning

confidence: 99%

Direct Solvent-Derived Polymer-Coated Nitrogen-Doped Carbon Nanodots with High Water Solubility for Targeted Fluorescence Imaging of Glioma

Wang

Meng

Wang

et al. 2015

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Cancer imaging requires biocompatible and bright contrast-agents with selective and high accumulation in the tumor region but low uptake in normal tissues. Herein, 1-methyl-2-pyrrolidinone (NMP)-derived polymer-coated nitrogen-doped carbon nanodots (pN-CNDs) with a particle size in the range of 5-15 nm are prepared by a facile direct solvothermal reaction. The as-prepared pN-CNDs exhibit stable and adjustable fluorescence and excellent water solubility. Results of a cell viability test (CCK-8) and histology analysis both demonstrate that the pN-CNDs have no obvious cytotoxicity. Most importantly, the pN-CNDs can expediently enter glioma cells in vitro and also mediate glioma fluorescence imaging in vivo with good contrast via elevated passive targeting.

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In Vivo Fluorescence Imaging with Ag₂S Quantum Dots in the Second Near‐Infrared Region

Cited by 663 publications

References 34 publications

Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy

Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy

LaF3 core/shell nanoparticles for subcutaneous heating and thermal sensing in the second biological-window

Direct Solvent-Derived Polymer-Coated Nitrogen-Doped Carbon Nanodots with High Water Solubility for Targeted Fluorescence Imaging of Glioma

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In Vivo Fluorescence Imaging with Ag2S Quantum Dots in the Second Near‐Infrared Region

Cited by 663 publications

References 34 publications

Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy

Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy

LaF3 core/shell nanoparticles for subcutaneous heating and thermal sensing in the second biological-window

Direct Solvent-Derived Polymer-Coated Nitrogen-Doped Carbon Nanodots with High Water Solubility for Targeted Fluorescence Imaging of Glioma

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In Vivo Fluorescence Imaging with Ag₂S Quantum Dots in the Second Near‐Infrared Region