In vivo fluid accumulation-inhibitory, anticolonization and anti-inflammatory and in vitro biofilm-inhibitory activities of methyl gallate isolated from Terminalia chebula against fluoroquinolones resistant Vibrio cholerae

Bag, Prasanta K.; Roy, Nivedita; Acharyya, Saurabh; Saha, Dhira Rani; Koley, Hemanta; Sarkar, Piyali; Bhowmik, Poulami

doi:10.1016/j.micpath.2018.12.037

Cited by 15 publications

(12 citation statements)

References 24 publications

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“…Methyl gallate ( 87 ) is a phenolic compound found in a variety of plant species such as Sedum aizoon L. (Crassulaceae) and Terminalia chebula Retz. (Combretaceae). , It is an ester of gallic acid and is biosynthesized from dehydroshikimate . Methyl gallate has high activity against the growth of S. aureus and moderate activity against V. cholerae and E. coli . , In a mouse model of cholera, oral administration of nontoxic doses (23.80–95.23 mg/kg) of methyl gallate significantly decreased inflammation, V. cholerae colonization and fluid accumulation in the intestines .…”

Section: Plant-derived Compounds With Antibacterial Propertiesmentioning

confidence: 99%

Ethnobotany and the Role of Plant Natural Products in Antibiotic Drug Discovery

et al. 2020

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The crisis of antibiotic resistance necessitates creative and innovative approaches, from chemical identification and analysis to the assessment of bioactivity. Plant natural products (NPs) represent a promising source of antibacterial lead compounds that could help fill the drug discovery pipeline in response to the growing antibiotic resistance crisis. The major strength of plant NPs lies in their rich and unique chemodiversity, their worldwide distribution and ease of access, their various antibacterial modes of action, and the proven clinical effectiveness of plant extracts from which they are isolated. While many studies have tried to summarize NPs with antibacterial activities, a comprehensive review with rigorous selection criteria has never been performed. In this work, the literature from 2012 to 2019 was systematically reviewed to highlight plant-derived compounds with antibacterial activity by focusing on their growth inhibitory activity. A total of 459 compounds are included in this Review, of which 50.8% are phenolic derivatives, 26.6% are terpenoids, 5.7% are alkaloids, and 17% are classified as other metabolites. A selection of 183 compounds is further discussed regarding their antibacterial activity, biosynthesis, structure−activity relationship, mechanism of action, and potential as antibiotics. Emerging trends in the field of antibacterial drug discovery from plants are also discussed. This Review brings to the forefront key findings on the antibacterial potential of plant NPs for consideration in future antibiotic discovery and development efforts.

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Section: Plant-derived Compounds With Antibacterial Propertiesmentioning

confidence: 99%

Ethnobotany and the Role of Plant Natural Products in Antibiotic Drug Discovery

et al. 2020

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“…[19]. Moreover, in vitro biofilm-inhibiting activity by C1-MG, isolated from Terminalia chebula against fluoroquinolone-resistant Vibrio cholera , has been reported [20]. C8-OG has shown significant antiviral, antifungal, and antibacterial potential [21,22,23] and has been used as an antioxidant and preservative [24,25].…”

Section: Introductionmentioning

confidence: 99%

Suppressive Effects of Octyl Gallate on Streptococcus mutans Biofilm Formation, Acidogenicity, and Gene Expression

et al. 2019

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The accumulation of biofilm by Streptococcus mutans bacteria on hard tooth tissues leads to dental caries, which remains one of the most prevalent oral diseases. Hence, the development of new antibiofilm agents is of critical importance. The current study reports the results from testing the effectiveness of octyl gallate (C8-OG) against: (1) S. mutans biofilm formation on solid surfaces (polystyrene, glass), (2) acidogenicity, (3) and the expression of biofilm-related genes. The amount of biofilm formed by S. mutans bacteria was evaluated using the colorimetric method and optical profilometry. The pH of the biofilm growth medium was measured with microelectrode. A quantitative reverse transcription-polymerase chain reaction (RT-qPCR) was used to assess the expression of genes encoding glucan binding protein B (gbpB), glucosyltransferases B, -C, -D (gtfB, -C, -D), and the F-ATPase β subunit of the F1 protein (atpD). The results show that C8-OG significantly diminished biofilm formation by exposed S. mutans on solid surfaces and suppressed acidogenicity in a dose-dependent manner, compared to unexposed bacteria (p < 0.05). The C8-OG concentration of 100.24 µM inhibited S. mutans biofilm development on solid surfaces by 100% and prevented a decrease in pH levels by 99%. In addition, the RT-qPCR data demonstrate that the biofilm-producing bacteria treated with C8-OG underwent a significant reduction in gene expression in the case of the four genes under study (gbpB, gtfC, gtfD, and atpD), and there was a slight decrease in expression of the gtfB gene. However, C8-OG treatments did not produce significant expression change compared to the control for the planktonic cells, although there was a significant increase for the atpD gene. Therefore, C8-OG might be a potent antibiofilm and/or anticaries agent for oral formulations that aim to reduce the prevalence of dental caries.

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“…The anti-Vibrio effects of RDRC could be due to the combined mode of action of different plant extracts present in the pill. Methyl gallate, one of the active ingredients of T. chebula Retz., a major component of RDRC has been found to act as an effective agent for the treatment of severe secretory and inflammatory diarrheal diseases caused by multidrug-resistant strains of V. cholerae (29). A high level of antibacterial activity was reported for V. parahaemolyticus by the use of extracts of Phytolacca americana Linn.…”

Section: Resultsmentioning

confidence: 99%

Anti-vibrio effects of the precious Tibetan pill, Rinchen Drangjor Rilnag Chenmo (RDRC)

et al. 2021

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Tibetan precious pills are an integral part of TTM (Traditional Tibetan Medicine). Among them, Rinchen Drangjor Rilnag Chenmo (RDRC) has been named “King of Precious Pills” due to its efficacy in treating a multitude of human disorders. RDRC has a complex formulation with about 140 ingredients, mostly from medicinal plants and a few precious stones and metals. Not many studies have been done on the experimental validation of antimicrobial properties of this important pill. The current study investigated the antimicrobial activity of the extracts of RDRC. Both aqueous and chloroform extracts were evaluated for their antibacterial potential against a total of seven different bacterial species, which are pathogenic, including three species of Vibrio, viz. V. vulnificus, V. parahaemolyticus and V. harveyi using the well-diffusion method and also by assessing MIC and MBC values. Its antifungal potential was also studied against two fungal strains Aspergillus niger and Talaromyces islandicus. It was found that the chloroform extract of RDRC exerted a positive antibacterial effect on all the Vibrio species tested, and the least MIC of 3.33 mg/ml was observed for V. parahaemolyticus. This is the first study of its kind on the anti-Vibrio effect of the Tibetan precious pill, Rinchen Drangjor Rilnag Chenmo.

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In vivo fluid accumulation-inhibitory, anticolonization and anti-inflammatory and in vitro biofilm-inhibitory activities of methyl gallate isolated from Terminalia chebula against fluoroquinolones resistant Vibrio cholerae

Cited by 15 publications

References 24 publications

Ethnobotany and the Role of Plant Natural Products in Antibiotic Drug Discovery

Ethnobotany and the Role of Plant Natural Products in Antibiotic Drug Discovery

Suppressive Effects of Octyl Gallate on Streptococcus mutans Biofilm Formation, Acidogenicity, and Gene Expression

Anti-vibrio effects of the precious Tibetan pill, Rinchen Drangjor Rilnag Chenmo (RDRC)

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