In vivo evidence that bezafibrate prevents oxidative stress and mitochondrial dysfunction caused by 3-methylglutaric acid in rat liver

Rosa-Junior, Nevton Teixeira da; Parmeggiani, Belisa; Glänzel, Nícolas Manzke; Alvorcem, Leonardo de Moura; Frusciante, Marina Rocha; Filho, Carlos Severo Dutra; Wajner, Moaçir; Leipnitz, Guilhian

doi:10.1016/j.biochi.2020.03.007

Cited by 10 publications

(3 citation statements)

References 42 publications

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“…Therefore, the decrease of vitamin D concentration in the light group may be the reason for the decrease of AMH hormone and melatonin in follicular fluid. In addition, continuous light exposure led to an increase in the concentrations of three microbial metabolites of glutaric acid, homovanillic acid and methylglutaric acid that cause oxidative stress in the intestinal tract 22–24 . After the three metabolites are absorbed into the blood, they would reach the ovary along with the blood circulation, causing oxidative stress in the ovary, increasing the ROS level of the oocyte, and eventually leading to the decline of oocyte quality.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, continuous light exposure led to an increase in the concentrations of three microbial metabolites of glutaric acid, homovanillic acid and methylglutaric acid that cause oxidative stress in the intestinal tract. [22][23][24] After the three metabolites are absorbed into the blood, they would reach the ovary along with the blood circulation, causing oxidative stress in the ovary, increasing the ROS level of the oocyte, and eventually leading to the decline of oocyte quality. Vaccaro et al found a similar phenomenon, with sleep deprivation increasing ROS level in the gut and ultimately leading to a significantly shorter lifespan in fruit flies.…”

Section: Discussionmentioning

confidence: 99%

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Gut microbiota–bile acid‐vitamin D axis plays an important role in determining oocyte quality and embryonic development

Li,

Song

et al. 2023

Clinical & Translational Med

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ObjectiveTo reveal whether gut microbiota and their metabolites are correlated with oocyte quality decline caused by circadian rhythm disruption, and to search possible approaches for improving oocyte quality.DesignA mouse model exposed to continuous light was established. The oocyte quality, embryonic development, microbial metabolites and gut microbiota were analyzed. Intragastric administration of microbial metabolites was conducted to confirm the relationship between gut microbiota and oocyte quality and embryonic development.ResultsFirstly, we found that oocyte quality and embryonic development decreased in mice exposed to continuous light. Through metabolomics profiling and 16S rDNA‐seq, we found that the intestinal absorption capacity of vitamin D was decreased due to significant decrease of bile acids such as lithocholic acid (LCA), which was significantly associated with increased abundance of Turicibacter. Subsequently, the concentrations of anti‐Mullerian hormone (AMH) hormone in blood and melatonin in follicular fluid were reduced, which is the main reason for the decline of oocyte quality and early embryonic development, and this was rescued by injection of vitamin D3 (VD3). Secondly, melatonin rescued oocyte quality and embryonic development by increasing the concentration of lithocholic acid and reducing the concentration of oxidative stress metabolites in the intestine. Thirdly, we found six metabolites that could rescue oocyte quality and early embryonic development, among which LCA of 30 mg/kg and NorDCA of 15 mg/kg had the best rescue effect.ConclusionThese findings confirm the link between ovarian function and gut microbiota regulation by microbial metabolites and have potential value for improving ovary function.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Gut microbiota–bile acid‐vitamin D axis plays an important role in determining oocyte quality and embryonic development

Li,

Song

et al. 2023

Clinical & Translational Med

View full text Add to dashboard Cite

show abstract

“…Additionally, the antioxidant capacity of PPAR-α agonist is related to elevating the expression of antioxidant enzymes and molecules such as catalase, superoxide dismutase, and GSH which directly protect the liver from the deleterious effects of hepatotoxicants [ 52 ]. In an animal study investigating hepatic mitochondrial damage and oxidative stress induced by 3-methyl glutaric acid, bezafibrate demonstrated protective effects by mitigating lipid peroxidation and preserving mitochondrial function [ 53 ]. The histopathological findings aided the biochemical results with maximum protection achieved by the combination group.…”

Section: Discussionmentioning

confidence: 99%

Study of the effect of bezafibrate with ginkgo biloba extracts in an animal model of hepatotoxicity induced by doxorubicin

Abdalla,

Abtar,

Kareem

et al. 2023

Biochemistry and Biophysics Reports

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Mitochondrial Dysfunction and Redox Homeostasis Impairment as Pathomechanisms of Brain Damage in Ethylmalonic Encephalopathy: Insights from Animal and Human Studies

2020

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In vivo evidence that bezafibrate prevents oxidative stress and mitochondrial dysfunction caused by 3-methylglutaric acid in rat liver

Cited by 10 publications

References 42 publications

Gut microbiota–bile acid‐vitamin D axis plays an important role in determining oocyte quality and embryonic development

Gut microbiota–bile acid‐vitamin D axis plays an important role in determining oocyte quality and embryonic development

Study of the effect of bezafibrate with ginkgo biloba extracts in an animal model of hepatotoxicity induced by doxorubicin

Mitochondrial Dysfunction and Redox Homeostasis Impairment as Pathomechanisms of Brain Damage in Ethylmalonic Encephalopathy: Insights from Animal and Human Studies

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