2014
DOI: 10.1167/iovs.14-15127
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In Vivo Evidence of Porcine Cornea Anisotropy Using Supersonic Shear Wave Imaging

Abstract: This preliminary study demonstrates the potential of SSI for the assessment of corneal anisotropy in both ex vivo and in vivo conditions.

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Cited by 58 publications
(47 citation statements)
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“…4 OCE is similar to other elastographic techniques such as ultrasound elastography (USE), 5 magnetic resonance elastography (MRE), 6 and supersonic shear wave imaging (SSI) [7][8][9] where an externally induced deformation is measured by the respective imaging modality. OCE has micrometer scale spatial resolution 10 and millisecond temporal resolution but has a limited penetration depth of a few millimeters in scattering media such as tissue.…”
mentioning
confidence: 99%
“…4 OCE is similar to other elastographic techniques such as ultrasound elastography (USE), 5 magnetic resonance elastography (MRE), 6 and supersonic shear wave imaging (SSI) [7][8][9] where an externally induced deformation is measured by the respective imaging modality. OCE has micrometer scale spatial resolution 10 and millisecond temporal resolution but has a limited penetration depth of a few millimeters in scattering media such as tissue.…”
mentioning
confidence: 99%
“…The high sensitivity of elastography further allows the use of micro-to nano-scale excitation that is nondestructive and therefore causes minimal influence to both structure and resident cells in engineered constructs. Furthermore, elastography has the ability to provide a high resolution 2D or 3D mapping of mechano-functional capacity of the material which can be used to deduce spatial heterogeneity 51,134 and anisotropy, 103,129 which are not accessible through traditional mechanical testing methods.…”
Section: The Value Of Elastography In Biomaterials and Tissuesmentioning
confidence: 99%
“…164 Instead of using shear waves, 103,104 the dispersion of vibration in the cornea was modeled as a surface wave propagating as a Lamb wave on a viscoelastic substrate. This approach is applicable to characterization of biomaterial substrates with thickness of less than 1 mm.…”
Section: Ultrasound Elastographymentioning
confidence: 99%
“…The surface wave equation does not take into account the corneal viscoelastic nonlinearity, 25,28 corneal curvature and thickness, 29 aqueous humor, 30 dispersion of the elastic wave, 31,32 or corneal mechanical anisotropy. 24,33 Additionally, the limited spatial and temporal data points resulted in the large variance in measured corneal biomechanical properties at 20 mmHg (stiff conditions), and the limited bandwidth of the air-pulse induced waves (below 1 kHz) combined with limited number of data points prevented dispersion analysis of the elastic wave. There are still several steps for improvement, which are the focus of our future work.…”
mentioning
confidence: 99%
“…For example, utilizing the both scans of the resonant scanner, 21 dispersion analysis 31,32,34 with a more rigorous mechanical wave model 31 will enable more accurate elasticity measurements. Acoustic techniques can also provide noncontact measurement of corneal biomechanical parameters, 33 but the presence of the coupling medium can be uncomfortable for in vivo corneal applications. In this case, air-coupled acoustic radiation force excitation with ultrafast OCE shows great promise for providing truly noncontact quantification of corneal viscoelasticity.…”
mentioning
confidence: 99%