In vivo evidence for an inhibitory glutamatergic control of serotonin release in the cat caudate nucleus: involvement of GABA neurons

Identification and Role of Serotonin 5‐HT1A and 5‐HT1B Receptors in Primary Cultures of Rat Embryonic Rostral Raphe Nucleus Neurons

“…TTX, known to block sodium channels and therefore action potentials, has already been used in vivo to determine whether glutamate and acetylcholine control 5-HT release directly or indirectly via interneuronal processes in the cat caudate nucleus (Becquet et al, 1988(Becquet et al, , 1990b. Moreover, Hjorth and Magnusson (1988) reported that inhibition of 5-HT synthesis and release induced by subcutaneous administration of 8-OH-DPAT was dependent on intact impulse flow in central serotoninergic neurons.…”

“…Information about the location of the 5-HT,, and 5-HT,, receptors involved in autoregulatory mechanisms was obtained using tetrodotoxin (TTX), which blocks the firing propagation from cell bodies to nerve endings. TTX has already been used in in vivo experiments to determine the location of receptors involved in the regulation of 5-HT release (Becquet et al, 1988(Becquet et al, , 1990b as well as in cell cultures to determine the electrical properties of oxytocin neurons (Jourdain et al, 1996) and the dynamic regulation of calcium influx by G proteins (Park and Dunlap, 1998). This firing blockade should enable us to determine whether 5-HT receptor agonists act at the somatodendritic or axon terminal level.…”

Increased striatal serotonin synthesis following cortical resection in children with intractable epilepsy

“…The effect of glutamatergic impairment on striatal serotonergic function is currently not well understood. Based on the findings that local administration of glutamate onto the caudate nucleus decreases serotonin release, presumably via GABAergic interneurons (Becquet et al, 1990), one might presume that the removal of glutamatergic neurons would increase serotonin release. Serotonergic innervation of the striatum is provided by the dorsal raphe nucleus, which also sends serotonergic projections to several other forebrain regions, including the frontal cortex (Vertes, 1991).…”

Dopamine receptor activation reveals a novel, kynurenate-sensitive component of striatal N-methyl-d-aspartate neurotoxicity

“…Because of the discrete pre-and postsynaptic, and intraand extrasynaptic, localization of the various receptor subunits (Bernard and Bolam, 1998;Wang and Pickel, 2000;Dunah and Standaert, 2003;Galvan et al, 2006), striatal NMDA receptor stimulation has multiple and complex functional effects. Moderate activation of NMDA receptors controls, for example, monoaminergic, cholinergic, glutamatergic and peptidergic neurotransmission (Becquet et al, 1990;Young and Bradford, 1993;Knauber et al, 1999;Hathway et al, 2001;Radke et al, 2001;Marti et al, 2005) and, as a consequence, affects synaptic plasticity (Centonze et al, 2004;Dang et al, 2006), motor function (Hallett et al, 2005;Gardoni et al, 2006) and cellular bioenergetics (Moncada and Bolanos, 2006 Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript.…”