In vivo evaluation of the biocompatibility of a new resin-based obturation system

The influence of three endodontic sealers on bone healing: an experimental study

“…Similar observations were made by Onay et al [12] or Batista et al [1], concluding that the two materials (AH Plus and Epiphany) are biocompatible.…”

Histological analysis of biocompatibility of ionomer cements with an acid-base reaction

“…Moreover, the analysis should be performed by means of qualitative and quantified evaluation. [11][12]15 Biocompatibility studies [22][23] have used polyethylene tubes as controls, 22 because they are considered harmless to the epithelial and conjunctive tissue. For this reason, they were used as such in this experiment.…”

“…7 These acids have been pointed out as being substances capable of causing oxidative stress within the cells and interfering in cellular response. 19 Moreover, the low pH of these materials, especially when recently prepared, may have an influence on the potential inflammatory response, [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] as supported by Ribeiro et al 7 These authors demonstrated that Ketac Cem cement powder did not induce alteration in cell DNA, whereas measurable genotoxicity was found for Ketac Cem liquid, composed of tartaric and benzoic acid, in all the dilutions tested in cell cultures.…”

“…15,22 In addition to the inflammatory infiltrate, circulatory alterations (edema) and multinucleated giant cells proved expressively greater with the Meron cement at 7 days, contrary to the respective results observed for the other cements. This was a proportional response of the body to the presence of aluminum and/or iron ions, [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] whereby giant cells are released in the tissue to promote phagocytosis, a process by which the ions are surrounded and contained. Moreover, leachable substances from the GICs may also affect the epithelial cell rate of progression through the cellular cycle.…”

Resilon: A Comprehensive Literature Review

“…126-129 Resilon has manifested less periradicular inflammation than gutta-percha. 2,130 However, some studies have shown that Resilon is more cytotoxic than gutta-percha and its cytotoxicity increases after 48 hours.…”