In vivo evaluation of the HeartWare MVAD Pump

McGee, Edwin C.; Chorpenning, Katherine; Brown, Mary Jane; Breznock, Eugene M.; LaRose, Jeffrey A.; Tamez, Daniel

doi:10.1016/j.healun.2013.10.003

Cited by 44 publications

(22 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…No electrical components are housed inside the pump, which contains only the stator core and the wires of the driveshaft connecting the motor to the controller. The housing of the pump is made of a titanium alloy and ceramic, and the impeller is made of magnetized platinum cobalt (4,5). With no sensitive electrical components inside the pump, there is significantly less risk of interference or pump failure.…”

Section: Discussionmentioning

confidence: 99%

“…As a result, VADs have been used as a bridge until a heart transplant becomes available or as a destination therapy (5-7). The MVAD Ò pump (currently for investigational use only; HeartWare Ò , Inc.) is a mechanical assist device with continuous, axial blood flow (5,8). The miniaturized design allows implantation in smaller patients, as well as allowing a potentially shorter hospital stay through use of less invasive surgery such as a thoracotomy (9,10).…”

mentioning

confidence: 99%

See 1 more Smart Citation

In Vitro PET Imaging of a Miniature Ventricular Assist Device

Gossman¹,

Graham

Depot

et al. 2016

J. Nucl. Med. Technol.

Self Cite

View full text Add to dashboard Cite

Interactions between the life-sustaining ventricular assist devices and diagnostic therapies must be carefully considered to decrease the risk of inaccurate diagnostic imaging or pump failure. Methods: The MVAD ® pump, currently under investigational use, was tested for interaction with radiotracers in an in vitro flow-loop study. The radiotracers 18 F-sodium fluoride and 18 F-FDG were injected into a closed loop to determine the feasibility of direct imaging of the MVAD ® pump in a PET scanner. Results: No real-time changes were observed in pump operation, and there were no statistical differences in pump parameters (power consumption, speed, and estimated flow rate) between the baseline and circulation conditions. In addition, no effect was observed on any external components, including the permissive-action-link controller and the batteries powering the device. Imaging of the internal pump components was possible, with obscuration observed only in the portion of the pump where the spinning impeller is located. Retention of radiotracer in the pump components after circulation was minimal (,1%). Conclusion: PET imaging is an attractive diagnostic tool for patients with a ventricular assist device and may have additional utility outside its current use, detection of infection.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

In Vitro PET Imaging of a Miniature Ventricular Assist Device

Gossman¹,

Graham

Depot

et al. 2016

J. Nucl. Med. Technol.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Currently, the device is approved as a bridge to cardiac transplantation and is being evaluated in the Clinical Trial to Evaluate the HeartWare Ventricular Assist System (ENDURANCE) trial for destination therapy in advanced heart failure patients [12]. The next generation miniature ventricular assist device (MVAD) pump (HeartWare Inc., Framingham, Massachusetts, USA) is a miniaturized axial ventricular assist device (VAD) that utilizes a magnetic and hydrodynamic impeller with wide helical flow channels to reduce shear stress [13] (Fig. 1c).…”

Section: Miniaturized Device: Sometimes Less Is Morementioning

confidence: 99%

The future of mechanical circulatory support for advanced heart failure

Marinescu

Uriel²,

Adatya³

2016

Current Opinion in Cardiology

View full text Add to dashboard Cite

show abstract

“…It has a wide-blade design to reduce shear force on blood components while providing 1 to 7 L/min of blood flow. 35 This device can be implanted through various minimally invasive approaches that do not necessitate median sternotomy, 36 including a right mini-thoracotomy with placement of a novel inflow cannula through the superior pulmonary vein, into the left atrium, and through the mitral valve into the LV. 37 Clinical trials are anticipated in the near future and are hoped to provide further tools in the armamentarium against end-stage heart failure.…”

Section: Future Applicationsmentioning

confidence: 99%

State of the Art of Mechanical Circulatory Support

Mallidi¹,

Anand

Cohn³

2014

Texas Heart Institute Journal

View full text Add to dashboard Cite

Mechanical circulatory support of the failing heart has become an important means of treating end-stage heart disease. This rapidly growing therapeutic field has produced impressive clinical outcomes and has great potential to help thousands of otherwise terminal patients worldwide. In this review, we examine the state of the art of mechanical circulatory support: current practice, totally implantable systems of the future, evolving biventricular support mechanisms, the potential for myocardial recovery and adjunctive treatment methods, and miniaturized devices with expanded indications for therapy.

show abstract

In vivo evaluation of the HeartWare MVAD Pump

Cited by 44 publications

References 13 publications

In Vitro PET Imaging of a Miniature Ventricular Assist Device

In Vitro PET Imaging of a Miniature Ventricular Assist Device

The future of mechanical circulatory support for advanced heart failure

State of the Art of Mechanical Circulatory Support

Contact Info

Product

Resources

About