In vivo evaluation of resorbable bone graft substitutes in a rabbit tibial defect model

Stubbs, David; Deakin, Mark; Chapman-Sheath, P.; Bruce, Warwick; Debes, Jack C.; Gillies, Robin R.; Walsh, William R.

doi:10.1016/j.biomaterials.2004.02.014

Cited by 129 publications

(95 citation statements)

References 34 publications

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“…Synthetic polymers such as polylactic acid (PLA) and poly(lactic-co-glycolic) acid as well as the mineral hydroxyapatite have been used as drug delivery matrices both alone and in composite systems [2, 4, 5-7, 11, 14, 33]. Another well-studied material used in the localized delivery of antibiotics is calcium sulfate [9,10,12,13,15,26,28,30,31,34,37]. Calcium sulfate is commonly used in combination with tobramycin in a commercially available kit from Wright Medical Technology (Arlington, TN).…”

Section: Introductionmentioning

confidence: 99%

Chitosan Films: A Potential Local Drug Delivery System for Antibiotics

Noel

Courtney

Bumgardner

et al. 2008

Clinical Orthopaedics &Amp; Related Research

104

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Local antibiotic delivery is an emerging area of study designed to provide alternative methods of treatment to clinicians for compromised wound sites where avascular zones can prevent the delivery of antibiotics to the infected tissue. Antibiotic-loaded bone cement is the gold standard for drug-eluting local delivery devices but is not ideal because it requires a removal surgery. Chitosan is a biocompatible, biodegradable polymer that has been used in several different drug delivery applications. We evaluated chitosan as a potential localized drug delivery device. We specifically determined if chitosan could elute antibiotics in an active form that would be efficacious in inhibiting S. aureus growth. Elution of amikacin was 24.67 ± 2.35 lg/mL (85.68%) after 1 hour with a final cumulative release of 27.31 ± 2.86 lg/mL (96.23%) after 72 hours. Elution of daptomycin was 10.17 ± 3.83 lg/mL after 1 hour (31.61% release) and 28.72 ± 6.80 lg/mL after 72 hours (88.55%). The data from the elution study suggested effective release of amikacin and daptomycin. The activity studies indicated the eluants inhibited the growth of S. aureus. Incorporating antibiotics in chitosan could provide alternative methods of treating musculoskeletal infections.

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Section: Introductionmentioning

confidence: 99%

Chitosan Films: A Potential Local Drug Delivery System for Antibiotics

Noel

Courtney

Bumgardner

et al. 2008

Clinical Orthopaedics &Amp; Related Research

104

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“…Biomaterial scaffolds, osteogenic cells, and bone formation-inductive factors are three essential elements for tissue engineering strategies to achieve repair and restoration of damaged bone tissues [37][38][39][40][41][42] . Scaffolds are central components of many tissue engineering strategies and there is a significant challenge in the design and manufacture of scaffolds that possess both a highly porous structure and the ability to control the release kinetics of growth factors over the period of tissue regeneration 43 .…”

Section: Discussionmentioning

confidence: 99%

Combination of poly L-lactic acid nanofiber scaffold with omentum graft for bone healing in experimental defect in tibia of rabbits

Sotoudeh

Jahanshahi²,

Jahanshahi³

et al. 2012

Acta Cir. Bras.

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PURPOSE: To investigate the osteoconductive properties and biological performance of Poly L-lactic acid (PLLA) with omentum in bone defects. METHODS: PLLA nanofiber scaffolds were prepared via electrospinning technique. Forty four New Zealand white female rabbits randomly divided into three groups of 18 rabbits each. Created defects in right tibias were filled in group I with omentum, in group II with PLLA nanofiber scaffold and in group III with combination of the omentum and PLLA. The same defects were created in left tibia of all groups but did not receive any treatment (control group). Histological and histomorphometric evaluations were performed at two, four and six weeks after the implantation. RESULTS: Histological changes on all groups along with the time course were scored and statistical analysis showed that the average scores in group III were significantly higher than the other groups. CONCLUSION: Histomorphometric analysis of bone healing was shown to be significantly improved by the combined PLLA with omentum compared with the other groups, suggesting this biomaterial promote the healing of cortical bone, presumably by acting as an osteoconductive scaffold.

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“…Los reactivos empleados para la obtención del gel fueron Ca(NO 3 3 de una disolución 1,00M de Ca(NO 3 ) 2 ·4H 2 O y de otra 0,67M de H 3 PO 4, ambas ajustadas a pH 10 con amoniaco concentrado. Las disoluciones se mezclaron rápidamente en un recipiente, y se mantuvieron con agitación continua por espacio de 10 minutos.…”

Section: Preparación De Las Pastasunclassified

“…De todos los materiales empleados para la reparación de estos defectos, las cerámicas de fosfatos cálcicos presentan un gran interés, y son ampliamente utilizadas, debido a su similitud con la fase mineral del hueso, su biocompatibilidad, su disponibilidad ilimitada y a estar libres de la transmisión de enfermedades (3)(4)(5)(6)(7). De entre las cerámicas de fosfatos cálcicos el fosfato tricálcico, (Ca 3 (PO 4 ) 2 , β-TCP) destaca por su carácter biorreabsorbible y osteoconductor (8)(9)(10)(11)(12), por lo que encuentra cada vez más aplicaciones médicas.…”

Section: Introductionunclassified

Obtención de fibras policristalinas de b-Ca3(PO4)2 para su empleo como material de relleno en procesos de reparación ósea

Franco-Vazquez¹,

Souto-Serante²,

Rey³

et al. 2007

Bol. Soc. Esp. Ceram. Vidr.

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El β-Ca 3 (PO 4 ) 2 (β-TCP) es un fosfato cálcico ampliamente empleado como material de relleno por la cirugía ortopédico restauradora en procesos de curación ósea, debido a su capacidad osteoconductora y alta tasa de biorreabsorción. Se emplea con distintas formas, tales como granulados, piezas compactas, piezas porosas, etc, dependiendo de la patología y el tipo de defecto óseo a tratar. Como alternativa a las formas ya existentes en el mercado, en el presente trabajo se obtuvieron fibras policristalinas de β-TCP por extrusión de masas plásticas preparadas a partir de polvo de β-TCP y metilcelulosa (MC) en agua. Se estudió la reología de las pastas y su comportamiento frente al esfuerzo y a la temperatura. Las fibras presentan distintos grosores, y características, que se obtienen variando el diámetro de las boquillas, la composición y la reología de las pastas. Los diámetros obtenidos van desde 350 µm a 150 µm. Finalmente se obtuvieron composites bifásicos β-TCP-Hidroxiapatito con microestructura controlada, utilizando las fibras de β-TCP como fase dispersa. Palabras clave: β-Ca 3 (PO 4 ) 2 (β-TCP), (Ca 10 (PO 4 ) 6 (OH) 2 , HA), Fibras policristalinas, Composites, Material de relleno óseo.Obtaining of β-Ca 3 (PO 4 ) 2 polycrystalline fibers for its employment as a filler in bone replacement material.β-TCP is a calcium phosphate ceramic widely employed by orthopaedic restorative surgery as a filler material in bone healing processes, due to its great osteoconductive capacity and great resorption rates. This material is available in several forms such as powders, dense and porous blocks, etc, depending on the pathology and the osseous defect to be treated. As an alternative to the β-TCP forms already available in the market, this work describes how to produce polycrystalline fibres by extruding plastic mixtures prepared with β-TCP powders, methyl cellulose (MC) and water. The rheology of the mixtures was studied versus time and frequency. The obtained fibres have different sizes and characteristics upon to the composition and rheology of the mixtures. The obtained diameters are between 150 µm and 350 µm. Finally, it has been prepared biphasic composites β-TCP/Hidroxylapatite (HA) with controlled microstructure, by employing the obtained fibres.

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In vivo evaluation of resorbable bone graft substitutes in a rabbit tibial defect model

Cited by 129 publications

References 34 publications

Chitosan Films: A Potential Local Drug Delivery System for Antibiotics

Chitosan Films: A Potential Local Drug Delivery System for Antibiotics

Combination of poly L-lactic acid nanofiber scaffold with omentum graft for bone healing in experimental defect in tibia of rabbits

Obtención de fibras policristalinas de b-Ca<sub>3</sub>(PO<sub>4</sub>)<sub>2</sub> para su empleo como material de relleno en procesos de reparación ósea

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