In vivo evaluation of post-operative pain reduction on rat model after implantation of intraperitoneal PET meshes functionalised with cyclodextrins and loaded with ropivacaine

Chai, Feng; Maton, Mickaël; Degoutin, Stéphanie; Vermet, G; Simon, Nicolas; Rousseaux, Christelle; Blanchemain, Nicolas

doi:10.1016/j.biomaterials.2018.07.032

Cited by 18 publications

(8 citation statements)

References 41 publications

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“…It can also reduce unnecessary oxygen consumption, prevent maternal and infant metabolic acidosis, reduce uteroplacental blood ow, and improve fetal oxygen and condition [8]. Related studies have found that dexmedetomidine can stable hemodynamics and analgesia, improve the e ect of the local anesthesia in cesarean section, and avoid the occurrence of adverse events [9][10][11]. In addition, ropivacaine can reduce the immune stress response of the parturients, so the combined use of the two exerts a promising clinical effect.…”

Section: Introductionmentioning

confidence: 99%

The Effectiveness and Safety of Ropivacaine and Medium-Dose Dexmedetomidine in Cesarean Section

Huang

Niu

2022

Evidence-Based Complementary and Alternative Medicine

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Objective: To study the effects of epidural anesthesia with different doses of dexmedetomidine and ropivacaine on postoperative hemodynamics and neonatal outcome of cesarean section parturients. Methods. A total of 90 parturients who underwent cesarean section admitted to our hospital from January 2019 to January 2020 were selected as the research objects and were divided into groups A, B, and C according to different dosages of dexmedetomidine, with 30 cases in each group. Groups A, B, and C were given dexmedetomidine 0.5 μg/kg, 0.8 μg/kg, 1.0 μg/kg, respectively, combined with 0.2% ropivacaine. The anesthesia effect, traction response, hemodynamic indexes, and neonatal Apgar score of the three groups were compared; the “Numerical Rating Scale (NRS) Score” was used to assess the postoperative pain of the parturients, and the “Ramsay Sedation Scale” was used to assess the sedation state of the parturients. Results. The superior anesthesia effect of group B was obtained compared with groups A and C ( P < 0.05 ). Group B witnessed a lower degree of grade III stretching response, as compared to group A ( P < 0.05 ). In comparison with groups A and C, superior results of the heart rate and mean artery pressure (MAP) of group B at T1 and T2 were obtained ( P < 0.05 ). The neonatal Apgar score in group B was lower than those in groups A and C ( P < 0.05 ), and the NRS score of group B was also lower than that of group A ( P < 0.05 ). Compared with groups A and C, group B yielded a more favorable outcome in terms of the Ramsay score ( P < 0.05 ). Conclusion. The use of medium-dose dexmedetomidine in cesarean section parturients is safer and can effectively reduce the impact on maternal hemodynamics, which is worthy of promotion and application.

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Section: Introductionmentioning

confidence: 99%

The Effectiveness and Safety of Ropivacaine and Medium-Dose Dexmedetomidine in Cesarean Section

Huang

Niu

2022

Evidence-Based Complementary and Alternative Medicine

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“…CD-based coatings have numerous potential applications relevant for inert polymeric substrates like PP. For example, on PP surgical textile implants, they could deliver antibiotics/drugs [19,24], or provide intrinsic resistance to protein/cell/bacterial attachment [32] to help mitigate complications related to inflammation, infection, and/or post-surgical tissue adhesion. On PP non-medical textiles, they could be used to improve fabric dyeability [30], for sustained and controlled release of insect repellent compounds [52][53][54] and fragrances [55][56][57], and for incorporating protectants against ultraviolet radiation [58,59] to which PP has known degradation susceptibility [60].…”

Section: Discussionmentioning

confidence: 99%

“…They have remarkable abilities to reversibly complex, through non-covalent interactions, with small nonpolar molecules or domains that "fit" in the pocket. Applications of these CD-based coatings include sustained delivery of antibiotics [18][19][20][21], drugs [22][23][24], pesticides [25], or fragrances [26], and efficient uptake and retention of pollutants [27,28] or dyes [29][30][31]. Additionally, due to the reversible nature of their molecular interactions, these coatings may be regenerated and reused multiple times.…”

Section: Introductionmentioning

confidence: 99%

Nonthermal Plasma Treatment Improves Uniformity and Adherence of Cyclodextrin-Based Coatings on Hydrophobic Polymer Substrates

2020

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Low surface energy substrates, which include many plastics and polymers, present challenges toward achieving uniform, adherent coatings, thus limiting intended coating function. These inert materials are common in various applications due to favorable bulk, despite suboptimal surface, properties. The ability to functionally coat low surface energy substrates holds broad value for uses across medicine and industry. Cyclodextrin-based materials represent an emerging, widely useful class of coatings, which have previously been explored for numerous purposes involving sustained release, enhanced sorption, and reversible reuse thereof. In this study, substrate exposure to nonthermal plasma was explored as a novel means to improve uniformity and adherence of cyclodextrin-based polyurethane coatings upon unreceptive polypropylene substrates. Plasma effects on substrates were investigated using contact angle goniometry and X-ray photoelectron spectroscopy (XPS). Plasma impact on coating uniformity was assessed through visualization directly and microscopically. Plasma effects on coating adhesion and bonding were studied with mechanical lap-shear testing and XPS, respectively. Substrate surface wettability and oxygen content increased with plasma exposure, and these modifications were associated with improved coating uniformity, adhesion, and interfacial covalent bonding. Findings demonstrate utility of, and elucidate mechanisms behind, plasma-based surface activation for improving coating uniformity, adherence, and performance on inert polymeric substrates.

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“…Several studies have reported applications of CD-based coatings both in biomedical [ 42 , 43 , 44 , 45 , 46 ] and nonbiomedical applications [ 16 , 37 , 39 , 47 , 48 , 49 , 50 ]. On the one hand, in the context of nonbiomedical applications, CD-based coatings have been used to prevent corrosion problems and to remediate pollutants or dyes.…”

Section: Coatings Of Cyclodextrin/citric Acid Biopolymer As Drug-deli...mentioning

confidence: 99%

Coatings of Cyclodextrin/Citric-Acid Biopolymer as Drug Delivery Systems: A Review

et al. 2023

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In the early 2000s, a method for cross-linking cyclodextrins (CDs) with citric acid (CTR) was developed. This method was nontoxic, environmentally friendly, and inexpensive compared to the others previously proposed in the literature. Since then, the CD/CTR biopolymers have been widely used as a coating on implants and other materials for biomedical applications. The present review aims to cover the chemical properties of CDs, the synthesis routes of CD/CTR, and their applications as drug-delivery systems when coated on different substrates. Likewise, the molecules released and other pharmaceutical aspects involved are addressed. Moreover, the different methods of pretreatment applied on the substrates before the in situ polymerization of CD/CTR are also reviewed as a key element in the final functionality. This process is not trivial because it depends on the surface chemistry, geometry, and physical properties of the material to be coated. The biocompatibility of the polymer was also highlighted. Finally, the mechanisms of release generated in the CD/CTR coatings were analyzed, including the mathematical model of Korsmeyer–Peppas, which has been dominantly used to explain the release kinetics of drug-delivery systems based on these biopolymers. The flexibility of CD/CTR to host a wide variety of drugs, of the in situ polymerization to integrate with diverse implantable materials, and the controllable release kinetics provide a set of advantages, thereby ensuring a wide range of future uses.

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In vivo evaluation of post-operative pain reduction on rat model after implantation of intraperitoneal PET meshes functionalised with cyclodextrins and loaded with ropivacaine

Cited by 18 publications

References 41 publications

The Effectiveness and Safety of Ropivacaine and Medium-Dose Dexmedetomidine in Cesarean Section

The Effectiveness and Safety of Ropivacaine and Medium-Dose Dexmedetomidine in Cesarean Section

Nonthermal Plasma Treatment Improves Uniformity and Adherence of Cyclodextrin-Based Coatings on Hydrophobic Polymer Substrates

Coatings of Cyclodextrin/Citric-Acid Biopolymer as Drug Delivery Systems: A Review

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