In vivo evaluation of chlorhexidine gluconate solution and sodium hypochlorite solution as root canal irrigants

Ringel, A. Michael; Patterson, Samuel S; Newton, Carl W.; Miller, Chris H.; Mulhern, John Martin

doi:10.1016/s0099-2399(82)80354-3

Cited by 105 publications

(76 citation statements)

References 22 publications

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“…7,8 In vivo and ex vivo studies comparing the antimicrobial effectiveness of chlorhexidine and NaOCl when used as irrigants during chemomechanical preparation have demonstrated conflicting results. Some studies have revealed that chlorhexidine is more effective, [9][10][11] others have reported that NaOCl is more effective, 12,13 whereas others have shown no significant difference between these 2 substances. 14,15 In vitro studies have also been inconsistent in their findings, with NaOCl more effective, [16][17][18] chlorhexidine more effective, 8 or no significant difference between the two.…”

mentioning

confidence: 99%

Bacteriologic investigation of the effects of sodium hypochlorite and chlorhexidine during the endodontic treatment of teeth with apical periodontitis

Siqueira

Rôças

Paiva

et al. 2007

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

143

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Objective. This clinical study was undertaken to compare the effectiveness of 2.5% sodium hypochlorite (NaOCl) and 0.12% chlorhexidine digluconate as irrigants in reducing the cultivable bacterial populations in infected root canals of teeth with apical periodontitis. Study design. According to stringent inclusion/exclusion criteria, 32 teeth with primary intraradicular infections and chronic apical periodontitis were selected and followed in the study. Bacterial samples were taken at the baseline (S1) and after chemomechanical preparation using either NaOCl (n ϭ 16) or chlorhexidine (n ϭ 16) as irrigants (S2). Cultivable bacteria recovered from infected root canals at the 2 stages were counted. Isolates from S2 samples were identified by means of 16S rRNA gene sequencing analysis.

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mentioning

confidence: 99%

Bacteriologic investigation of the effects of sodium hypochlorite and chlorhexidine during the endodontic treatment of teeth with apical periodontitis

Siqueira

Rôças

Paiva

et al. 2007

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

143

View full text Add to dashboard Cite

show abstract

“…Several investigators have suggested the use of chlorhexidine gluconate as an equally valuable root canal irrigant. It has ability to be absorbed and released by dental tissues, would disinfect the tissues and then maintain a root canal devoid of microorganisms by sustained release of CHX gluconate into the root canals 20) . CHX gluconate is a cationic bisguanide which combines to the cell wall of the microorganism and causes leakage of intra cellular components.…”

Section: ⅳ Discussionmentioning

confidence: 99%

Evaluation of time-dependent antimicrobial effect of sodium dichloroisocyanurate (NaDCC) onEnterococcus faecalisin the root canal

Kim

Park

Cho

et al. 2007

J Korean Acad Conserv Dent

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The purpose of this study was to assess the antibacterial effect of sodium dichloroisocyanurate (NaDCC), sodium hypochlorite (NaOCl), and chlorhexidine (CHX) on Enterococcus faecalis and to evaluate and to compare the time-dependant antimicrobial effect of NaDCC with NaOCl and CHX in the root canal in vitro before and after instrumentation.Extracted human single teeth were prepared by serial instrumentation technique. The samples were autoclaved and contaminated for 3 days with E. faecalis monocultures. The teeth were then divided into 4 groups. Each group was irrigated and inserted with 2% NaOCl, 2% NaDCC, 2% CHX and sterilized saline. After 6, 12, 24, 72h, and 1 week incubation, sterilized paper point was inserted into the root canal. Paper points containing root canal contents were then placed on the agar plate. And then each root canal was prepared with #4 and #5 GG (Gates-Glidden) drill. The debris were collected in the sterilized microtube and the plates were incubated at 37℃ in an increased CO2 atmosphere. After 24h incubation the growth of bacteria around the paper points were measured. NaOCl and NaDCC solution shows similar antimicrobial effect for E. faecalis at 6, 12, 24, 72h and 1 week. In control group, irrigated with sterilized saline, no antimicrobial effect was observed.The results are in agreement with other investigators, who have shown the bactericidal property and possibility of NaDCC as a root canal irrigation solution. Thus it seems that NaDCC solutions can be clinically applied into the root canal within 1 week after dilution. [J Kor Acad Cons Dent 32(2):121-129, 2007]

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“…Despite its usefulness as a final irrigant, chlorhexidine cannot be advocated as the main irrigant in standard endodontic cases, because: (a) chlorhexidine is unable to dissolve necrotic tissue remnants (Naenni et al, 2004), and (b) chlorhexidine is less effective on Gram-negative than on Gram-positive bacteria (Hennessey,1973). In a randomized clinical trial on the reduction of intracanal microbiota by either 2.5% NaOCl or 0.2% chlorhexidine irrigation, it was found that hypochlorite was significantly more efficient than chlorhexidine in obtaining negative cultures (Ringel, 1982). Most important CHX disadvantage is its inability of to dissolve necrotic tissue remnants and chemically clean the canal system.…”

Section: Chlorhexidinementioning

confidence: 99%

Antibacterial Agents in Dental Treatments

Rahimi¹,

Milani²,

Ghasemi³

et al. 2012

Antimicrobial Agents

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In vivo evaluation of chlorhexidine gluconate solution and sodium hypochlorite solution as root canal irrigants

Cited by 105 publications

References 22 publications

Bacteriologic investigation of the effects of sodium hypochlorite and chlorhexidine during the endodontic treatment of teeth with apical periodontitis

Bacteriologic investigation of the effects of sodium hypochlorite and chlorhexidine during the endodontic treatment of teeth with apical periodontitis

Evaluation of time-dependent antimicrobial effect of sodium dichloroisocyanurate (NaDCC) onEnterococcus faecalisin the root canal

Antibacterial Agents in Dental Treatments

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