In vivo evaluation and comparison of collagen, acetylated collagen and collagen/glycosaminoglycan composite films and sponges as candidate biomaterials

Srivastava, S.; Gorham, S. D.; French, D. A.; Shivas, A A; Courtney, J. M.

doi:10.1016/0142-9612(90)90148-j

Cited by 54 publications

(28 citation statements)

References 21 publications

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“…Ceramics generally have very low tensile strength, are brittle, and cannot be used in locations of significant torsion such as long bones [3,4,[59][60][61]. Alternatively, biomaterials such as type I collagen base implants are frequently used but have limitations related to rapid biodegradation or -when stabilized through cross-linking -foreign body responses and uncontrolled calcification [62,63].…”

Section: Discussionmentioning

confidence: 99%

Silk based biomaterials to heal critical sized femur defects

Meinel

Betz

Fajardo

et al. 2006

Bone

219

179

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Section: Discussionmentioning

confidence: 99%

Silk based biomaterials to heal critical sized femur defects

Meinel

Betz

Fajardo

et al. 2006

Bone

219

179

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“…As well as absorbable and non-absorbable synthetics, biomaterials with chondroconductive properties based on natural polymers, particularly collagen have been developed [1][2][3][4][5][6][7][8][9][10][11][12][13][14]. Collagen substrates are known to influence the growth characteristics of cells and also to modulate various aspects of cell behavior like cell-adhesion, proliferation and differentiation [3,9,10,[15][16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Influence of different collagen species on physico-chemical properties of crosslinked collagen matrices

et al. 2004

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“…For that reason, collagen is often considered an optimal dressing for wound care. 4,[6][7][8][9] Proliferation of bacteria in wounds can be reduced naturally by phagocytosis or other immune processes. However, a topical antimicrobial treatment of infected chronic wounds may be necessary in immunocompromised patients.…”

Section: Introductionmentioning

confidence: 99%

A new anti-infective collagen dressing containing antibiotics

Grzybowski

Kolodziej²,

Trafny

et al. 1997

J. Biomed. Mater. Res.

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A new antibacterial dressing for infected wounds was prepared. The dressing was composed of a collagen membrane and collagen sponge; both biomaterials possess good tissue biocompatibility. An active antibacterial layer of limited hydrophobicity was placed between the membrane and the sponge and into the upper part of the sponge. The dressing contained gentamycin or amikacin at concentrations of 0.3 microgram/cm2 (loading level of the drug utilized during preparation of the dressing). Either the antibiotic or its concentration easily can be changed in the dressing by the manufacturer. The dressing was stable for several months. The antibiotic was released slowly from the dressing in in vitro experiments for 3 days. Antibacterial activity of the dressing was tested using a mouse wound model experimentally infected with Pseudomonas aeruginosa. Both dressings, containing either amikacin or gentamycin, reduced the number of living bacterial cells in the infected tissue almost to zero during the course of observation. The new dressing may be effective in the treatment of infected wounds in patients.

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In vivo evaluation and comparison of collagen, acetylated collagen and collagen/glycosaminoglycan composite films and sponges as candidate biomaterials

Cited by 54 publications

References 21 publications

Silk based biomaterials to heal critical sized femur defects

Silk based biomaterials to heal critical sized femur defects

Influence of different collagen species on physico-chemical properties of crosslinked collagen matrices

A new anti-infective collagen dressing containing antibiotics

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