In vivo engineering of blood vessels

Daly, Chris; Campbell, Gordon; Walker, Philip J.; Campbell, Julie H.

doi:10.2741/1384

Cited by 26 publications

(11 citation statements)

References 47 publications

(53 reference statements)

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“…Multiple scaffold materials and techniques have been implemented for the fabrication of such grafts, including a poly glycolic acid sleeve reinforced with a copolymer of e-caprolactone and L-lactide, 4 poly glycolic acid, poly-llactic acid (PLLA), hydrogels, collagen sheets, decellularized matrices, electrospun fibers, and mandrils of foreign body implanted into the peritoneum of animals. 66 Building the scaffolds, however, is just the first step in developing TEVGs for clinical use. Cell seeding remains a more critical step in the construction of these grafts and thus has been a major focus of research.…”

Section: Discussionmentioning

confidence: 99%

Cell-Seeding Techniques in Vascular Tissue Engineering

Villalona

Udelsman

Duncan

et al. 2010

Tissue Engineering Part B: Reviews

182

136

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Section: Discussionmentioning

confidence: 99%

Cell-Seeding Techniques in Vascular Tissue Engineering

Villalona

Udelsman

Duncan

et al. 2010

Tissue Engineering Part B: Reviews

182

136

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“…[3][4][5][6] Here, we review the progress in all major facets of the field based on in vitro and ex vivo approaches; in vivo approaches are reviewed elsewhere. 7,8 Many design criteria have been proposed for the development of a functional small-diameter arterial replacement graft. 2,5,6,9 -13 It must be biocompatible, ie, nonthrombogenic, nonimmunogenic, and resistant to infection, all of which are associated with a confluent, quiescent, nonactivated endothelium.…”

mentioning

confidence: 99%

Small-Diameter Artificial Arteries Engineered In Vitro

Isenberg

Williams

Tranquillo

2006

Circulation Research

439

320

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Abstract-Although the need for a functional arterial replacement is clear, the lower blood flow velocities of small-diameter arteries like the coronary artery have led to the failure of synthetic materials that are successful for large-diameter grafts. Although autologous vessels remain the standard for small diameter grafts, many patients do not have a vessel suitable for use because of vascular disease, amputation, or previous harvest. As a result, tissue engineering has emerged as a promising approach to address the shortcomings of current therapies. Investigators have explored the use of arterial tissue cells or differentiated stem cells combined with various types of natural and synthetic scaffolds to make tubular constructs and subject them to chemical and/or mechanical stimulation in an attempt to develop a functional small-diameter arterial replacement graft with varying degrees of success. Here, we review the progress in all these major facets of the field. Key Words: tissue engineering Ⅲ artery Ⅲ collagen Ⅲ elastin Ⅲ vascular graft I n 2002, more than 500 000 surgical procedures were performed involving replacement of small-caliber blood vessels. 1 Despite a clear clinical need for a functional arterial graft, success has been limited to arterial replacements of large-caliber vessels such as the thoracic and abdominal aorta, arch vessels, iliac, and common femoral arteries; however, small-caliber (Ͻ6 mm) arterial substitutes, which account for a majority of the demand, have generally proved inadequate largely because of acute thrombogenicity of the graft, anastomotic intimal hyperplasia, aneurysm formation, infection, and progression of atherosclerotic disease. 2 The lower blood flow velocities of smaller vessels pose a different set of design criteria and introduce a host of new problems not encountered in large-caliber arterial substitutes where Dacron and expanded polytetrafluorethylene grafts have succeeded.Although autologous vessels, such as the saphenous vein, remain the standard for small diameter grafts, many patients do not have a vessel suitable for use because of vascular disease, amputation, or previous harvest. Moreover, this method requires a second surgical procedure to obtain the vessel. Tissue engineering has emerged as a promising approach to address the shortcomings of current options. Investigators have explored the use of arterial tissue cells combined with various types of natural and synthetic scaffolds to make tubular constructs and subject them to chemical and/or mechanical stimulation in an attempt to develop a functional small-diameter arterial replacement graft with varying degrees of success. There have been several reviews of vascular tissue engineering studies in recent years. [3][4][5][6] Here, we review the progress in Many design criteria have been proposed for the development of a functional small-diameter arterial replacement graft. 2,5,6,9 -13 It must be biocompatible, ie, nonthrombogenic, nonimmunogenic, and resistant to infection, all of which are associated wi...

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“…45 Efforts continue to develop a tissue-engineered vascular graft, grown in the peritoneal cavity on silastic tubes, which could be used for arterial revascularization or as an arteriovenous access conduit. 46,47 This methodology has recently been used to grow myofibroblast-rich tubular structures and tissue capsules for use as autologous grafts for hollow, smooth muscle-walled visceral organs, including the bladder, uterus, and vas deferens. 48 Most recently, investigators in Sydney have commenced a program of hyperperfusion for peripheral artery disease patients facing amputation, the Hypertensive Extracorporeal Limb Perfusion (HELP) study.…”

Section: Research Challenges For Vascular Surgery In Australasiamentioning

confidence: 99%