In vivo Electrophysiological Study of Induced Ventricular Tachycardia in Intact Rat Model of Chronic Ischemic Heart Failure

Weigand, Kyle; Witte, Russell S.; Moukabary, Talal; Chinyere, Ike; Lancaster, Jordan J.; Pierce, Mary K.; Goldman, Steven; Juneman, Elizabeth

doi:10.1109/tbme.2016.2605578

Cited by 14 publications

(8 citation statements)

References 32 publications

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“…However, after 2 weeks, the APD begins to increase and returns to normal values after 8 weeks. Similarly, normal APD values were also found in murine epicardial BZ tissue 6 weeks after MI (Weigand et al, 2016 ), suggesting that the healing process is complete earlier in this species.…”

Section: Review Of Experimental Data Of the Electrophysiological Rmentioning

confidence: 63%

“…APD shortening was also found in feline (Wong et al, 1982 ; Kimura et al, 1986 ), although measurements of neither I CaL nor I KAS were reported in those studies. On the other hand, the canine (Gardner et al, 1985 ; Ursell et al, 1985 ), porcine (Denisko et al, 2017 ), murine (Weigand et al, 2016 ), and human (Dangman et al, 1982 ) BZ of healed infarcts exhibit normal APD, while APD prolongation has also been found in rabbits with healed infarcts (Litwin and Bridge, 1971 ).…”

Section: Review Of Experimental Data Of the Electrophysiological Rmentioning

confidence: 99%

“…The fact that APD shortening was found in feline 2 months after MI, but not in canine murine, and humans might be explained by differences in the specific coronary occlusion techniques implemented. For instance, the ligation technique employed in the feline experiments (Myerburg et al, 1982 ; Wong et al, 1982 ; Kimura et al, 1986 , 1988 ; Pinto et al, 1997 ) was specifically developed to induce long term EP changes after MI (Myerburg et al, 1977 ), whereas the ligation technique employed in the murine experiments (Mills et al, 2005 ; Rutherford, 2013 ; Weigand et al, 2016 ) was designed to reduce infarct size and mortality rate after acute ischemia (Maclean et al, 1978 ), thus, likely attenuating EP remodeling in healed infarcts. Moreover, coronary occlusion followed by reperfusion was performed in canine (Spear et al, 1983 ) and the total repolarization time (APD 100 ) was normal 5 and 14 days after MI, suggesting that this technique might also attenuate EP remodeling in healed infarcts.…”

Section: Review Of Experimental Data Of the Electrophysiological Rmentioning

confidence: 99%

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Modeling the Electrophysiological Properties of the Infarct Border Zone

et al. 2018

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Ventricular arrhythmias (VA) in patients with myocardial infarction (MI) are thought to be associated with structural and electrophysiological remodeling within the infarct border zone (BZ). Personalized computational models have been used to investigate the potential role of the infarct BZ in arrhythmogenesis, which still remains incompletely understood. Most recent models have relied on experimental data to assign BZ properties. However, experimental measurements vary significantly resulting in different computational representations of this region. Here, we review experimental data available in the literature to determine the most prominent properties of the infarct BZ. Computational models are then used to investigate the effect of different representations of the BZ on activation and repolarization properties, which may be associated with VA. Experimental data obtained from several animal species and patients with infarct show that BZ properties vary significantly depending on disease's stage, with the early disease stage dominated by ionic remodeling and the chronic stage by structural remodeling. In addition, our simulations show that ionic remodeling in the BZ leads to large repolarization gradients in the vicinity of the scar, which may have a significant impact on arrhythmia simulations, while structural remodeling plays a secondary role. We conclude that it is imperative to faithfully represent the properties of regions of infarction within computational models specific to the disease stage under investigation in order to conduct in silico mechanistic investigations.

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Section: Review Of Experimental Data Of the Electrophysiological Rmentioning

confidence: 63%

Section: Review Of Experimental Data Of the Electrophysiological Rmentioning

confidence: 99%

Section: Review Of Experimental Data Of the Electrophysiological Rmentioning

confidence: 99%

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Modeling the Electrophysiological Properties of the Infarct Border Zone

et al. 2018

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“…Whole-heart in vivo electrical pacing from healthy tissue near the apex of the LV was performed using a function generator. 16…”

Section: Echocardiographymentioning

confidence: 99%

Human Induced Pluripotent Stem Cell–Derived Cardiomyocyte Patch in Rats With Heart Failure

Lancaster

Sanchez

Repetti

et al. 2019

The Annals of Thoracic Surgery

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“…Rats are the most commonly used laboratory animal for assessing ischemia-reperfusion injury in experiments. They are used to study the mechanisms of post-infarction pathology and to develop approaches reducing adverse cardiac events following ischemia-reperfusion injury in the myocardium [5][6][7]. In addition to experimental studies, an anatomically accurate computer modeling of the heart has become a valuable process for investigations of cardiac arrhythmia mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Anatomical Model of Rat Ventricles to Study Cardiac Arrhythmias under Infarction Injury

et al. 2021

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Species-specific computer models of the heart are a novel powerful tool in studies of life-threatening cardiac arrhythmias. Here, we develop such a model aimed at studying infarction injury in a rat heart, the most common experimental system to investigate the effects of myocardial damage. We updated the Gattoni2016 cellular ionic model by fitting its parameters to experimental data using a population modeling approach. Using four selected cellular models, we studied 2D spiral wave dynamics and found that they include meandering and break-up. Then, using an anatomically realistic ventricular geometry and fiber orientation in the rat heart, we built a model with a post-infarction scar to study the electrophysiological effects of myocardial damage. A post-infarction scar was simulated as an inexcitable obstacle surrounded by a border zone with modified cardiomyocyte properties. For cellular models, we studied the rotation of scroll waves and found that, depending on the model, we can observe different types of dynamics: anchoring, self-termination or stable rotation of the scroll wave. The observed arrhythmia characteristics coincide with those measured in the experiment. The developed model can be used to study arrhythmia in rat hearts with myocardial damage from ischemia reperfusion and to examine the possible arrhythmogenic effects of various experimental interventions.

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In vivo Electrophysiological Study of Induced Ventricular Tachycardia in Intact Rat Model of Chronic Ischemic Heart Failure

Abstract: The in vivo rat model of CHF combined with EP analysis could be used to determine the arrhythmogenic potential of new treatments for CHF.

Cited by 14 publications

References 32 publications

Modeling the Electrophysiological Properties of the Infarct Border Zone

Modeling the Electrophysiological Properties of the Infarct Border Zone

Human Induced Pluripotent Stem Cell–Derived Cardiomyocyte Patch in Rats With Heart Failure

Anatomical Model of Rat Ventricles to Study Cardiac Arrhythmias under Infarction Injury

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