In vivo efficacy studies of chromene-based compounds in triple-negative breast cancer – A systematic review

Oliveira-Pinto, Sofia; Pontes, Olívia; Baltazar, Fátima; Costa, Marta

doi:10.1016/j.ejphar.2020.173452

Cited by 22 publications

(14 citation statements)

References 34 publications

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“…1,2,3-TRIAZOLE-CONTAINING CHROMENE/COUMARIN DERIVATIVES Chromene (benzopyran) and coumarin (chromen-2-one) moieties are present in a large number of biologically active compounds, and their derivatives are potent inhibitors of a variety of proteins, such as EGFR, tyrosine kinase, ERK1/2, PI3K, HSP 90, Bax, STAT proteins, nuclear factor kappa-lightchain-enhancer of activated B cells (NF-κB), and telomerase associated with lung cancer (Manjinder et al, 2015;Manvendra et al, 2018;Al-Warhi et al, 2020;Oliveira-Pinto et al, 2020). Therefore, therapeutic drug candidates could be obtained by combination of 1,2,3-triazole and chromene/ coumarin for the treatment of lung cancer, even drug-resistant and multidrug-resistant (MDR) forms.…”

Section: Introductionmentioning

confidence: 99%

1,2,3-Triazole-Containing Compounds as Anti–Lung Cancer Agents: Current Developments, Mechanisms of Action, and Structure–Activity Relationship

Liang

Sun

et al. 2021

Front. Pharmacol.

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Lung cancer is the most common malignancy and leads to around one-quarter of all cancer deaths. Great advances have been achieved in the treatment of lung cancer with novel anticancer agents and improved technology. However, morbidity and mortality rates remain extremely high, calling for an urgent need to develop novel anti–lung cancer agents. 1,2,3-Triazole could be readily interact with diverse enzymes and receptors in organisms through weak interaction. 1,2,3-Triazole can not only be acted as a linker to tether different pharmacophores but also serve as a pharmacophore. This review aims to summarize the recent advances in 1,2,3-triazole–containing compounds with anti–lung cancer potential, and their structure–activity relationship (SAR) together with mechanisms of action is also discussed to pave the way for the further rational development of novel anti–lung cancer candidates.

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Section: Introductionmentioning

confidence: 99%

1,2,3-Triazole-Containing Compounds as Anti–Lung Cancer Agents: Current Developments, Mechanisms of Action, and Structure–Activity Relationship

Liang

Sun

et al. 2021

Front. Pharmacol.

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“…Chromene and its derivatives are prominent scaffolds in medicinal chemistry, displaying significant bioactivities like anticancer, antifungal, antimicrobial, anti-inflammatory, antiproliferative and antiangiogenic activities. [49] Chromeno-[4,3b]pyridines have been reported as estrogen receptor βselective ligands, TNF-α inhibitors and as anti-inflammatory agents. [50] The structural motif of the chromeno-[4,3-b]pyridine provide ample scope for further molecular modifications and hence are sought after in medicinal chemistry.…”

Section: Chromeno-[34-c]-pyridinesmentioning

confidence: 99%

3‐Arylidene‐4‐Chromanones and 3‐Arylidene‐4‐Thiochromanones: Versatile Synthons towards the Synthesis of Complex Heterocycles

2022

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Heterocyclic compounds are well-known for their use in the synthesis of drugs and drug intermediates. This review provides a systematic survey on the chemical synthesis of complex heterocyclic compounds containing multistereocentres using 3-arylidene-4-chromanones in the last two decades. Regioselective and stereoselective synthesis of complex heterocycles involving 3-arylidene-chromanones and 3-arylidene-thiochormanones are dealt under various reaction headings such as epoxidation, Michael addition, 1,3dipolar cycloaddition, [3 + 2] and [4 + 2] cycloaddition, Diels-Alder reaction, sulfa-Michael/aldol cascade reactions, asym-metric synthesis employing bifunctional catalysts, chiral phase-transfer catalysts, chiral squaramide catalysts, etc. These synthetic highlights demonstrate the utility of 3arylidene-4-chromanones and 3-arylidene-thiochormanones as versatile synthons for rapid assemblage of complex condensed heterocyles and spiro-fused heterocycles towards the development of pharmaceutically active compounds. A brief highlight on the synthetic methods of 3-arylidene-4chromanone derivatives is also dealt. This review creates a platform for further improvement on the skeletal design of potential drug candidates.

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“…In particular, the possible anticancer activities have been the most investigated, but biological activities such as antimicrobial, antiviral, anti-inflammatory, antioxidant properties, treatment of skin disorders, and diabetes mellitus, among others, have also been reported. They are also increasingly used for the therapy of neurodegenerative diseases such as Down syndrome, Parkinson's disease, Alzheimer's disease, schizophrenia, and AIDS-related insanity [79][80][81][82][83][84].…”

Section: Chromenes and Xanthenesmentioning

confidence: 99%

Recent Applications of Heteropolyacids and Related Compounds in Heterocycle Synthesis. Contributions between 2010 and 2020

et al. 2021

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Over the past two decades, polyoxometalates (POM) have received considerable attention as solid catalysts, due to their unique physicochemical characteristics, since, first, they have very strong Bronsted acidity, approaching the region of a superacid, and second, they are efficient oxidizers that exhibit rapid redox transformations under fairly mild conditions. Their structural mobility is also highlighted, since they are complex molecules that can be modified by changing their structure or the elements that compose them to model their size, charge density, redox potentials, acidity, and solubility. Finally, they can be used in substoichiometric amounts and reused without an appreciable loss of catalytic activity, all of which postulate them as versatile, economic and ecological catalysts. Therefore, in 2009, we wrote a review article highlighting the great variety of organic reactions, mainly in the area of the synthesis of bioactive heterocycles in which they can be used, and this new review completes that article with the contributions made in the same area for the period 2010 to 2020. The synthesized heterocycles to be covered include pyrimidines, pyridines, pyrroles, indoles, chromenes, xanthenes, pyrans, azlactones, azoles, diazines, azepines, flavones, and formylchromones, among others.

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In vivo efficacy studies of chromene-based compounds in triple-negative breast cancer – A systematic review

Cited by 22 publications

References 34 publications

1,2,3-Triazole-Containing Compounds as Anti–Lung Cancer Agents: Current Developments, Mechanisms of Action, and Structure–Activity Relationship

1,2,3-Triazole-Containing Compounds as Anti–Lung Cancer Agents: Current Developments, Mechanisms of Action, and Structure–Activity Relationship

3‐Arylidene‐4‐Chromanones and 3‐Arylidene‐4‐Thiochromanones: Versatile Synthons towards the Synthesis of Complex Heterocycles

Recent Applications of Heteropolyacids and Related Compounds in Heterocycle Synthesis. Contributions between 2010 and 2020

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