In vivo efficacy of top five surveyed Ghanaian herbal anti-malarial products

Wilmot, Dennis; Ameyaw, Elvis Ofori; Amoako-Sakyi, Daniel; Boampong, Johnson Nyarko; Quashie, Neils B

doi:10.1186/s12936-017-1757-4

Cited by 17 publications

(19 citation statements)

References 14 publications

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“…Nonetheless, such medications are considered by many as an acceptable treatment of malaria and, in all fairness, also need to be distinguished clearly from more "magical" forms of treatments, such as the ones offered by fetish priests [11]. In other words, whilst such herbal remedies may not be able to rely on a firm scientific basis and scrutiny, they can rely on centuries of experience and "history" [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Antimalarial Drugs in Ghana: A Case Study on Personal Preferences

Yeboah

Forkuo

Amponsah

et al. 2020

Sci

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Malaria is a serious infection affecting millions of people in Africa. Our study investigated the personal preferences and applications of antimalarial medicines in Ghana. Based on over 1000 questionnaires distributed in Ghana from January to May 2019, we noticed that although Western medications to fight this disease are widely available, most patients in Ghana prefer treatment with locally produced herbal remedies. This preference appears to be due to a combination of traditional venues for obtaining medicines “on the street” rather than in licensed pharmacies, trust in local and “green” products, extensive advertisement of such local products, and an inherent distrust of imported and synthetic or orthodox medicines. Going local and natural is a trend also observed in other countries across the globe and adds to the acceptance or rejection of drugs regardless of their activity or toxicity. In fact, adverse side effects associated with herbal remedies, such as general weakness, swelling and sore mouth, do not seem to deter the respondents of this study in Ghana. We propose a combination of (a) increasing public awareness of the benefits of modern medicine and (b) an improvement and control of the quality of herbal remedies to raise the standard for the treatment of malaria in countries such as Ghana.

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Section: Introductionmentioning

confidence: 99%

Antimalarial Drugs in Ghana: A Case Study on Personal Preferences

Yeboah

Forkuo

Amponsah

et al. 2020

Sci

View full text Add to dashboard Cite

show abstract

“…Nonetheless, such medications are seen by many as an acceptable treatment of malaria and, in all fairness, also need to be distinguished clearly from more "magical" forms of treatments, such as the ones offered by fetish priests [11]. In other words, whilst such herbal remedies may not be able to rely on a firm scientific basis and scrutiny, they can rely on centuries of experience and "history" [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Antimalarial Drugs in Ghana: A Case Study on Personal Preferences

Yeboah¹,

Forkuo²,

Amponsah³

et al. 2020

Sci

View full text Add to dashboard Cite

Malaria is a serious infection affecting millions of people in Africa. Our study investigated the personal preferences and applications of antimalarial medicines in Ghana. Based on over 1000 questionnaires distributed in Ghana from January to May 2019, we noticed that although Western medications to fight this disease are widely available, most patients in Ghana prefer treatment with locally produced herbal remedies. This preference appears to be due to a combination of traditional venues for obtaining medicines “on the street” rather than in licensed pharmacies, trust in local and “green” products, extensive advertisement of such local products, and an inherent distrust of imported and synthetic or unnatural medicines. Going local and natural is a trend also observed in other countries across the globe, and adds to the acceptance or rejection of drugs regardless of their activity or toxicity. In fact, adverse side effects associated with herbal remedies, such as general weakness and swollen, sore mouth, do not seem to deter the respondents of this study in Ghana. We propose a combination of (a) increasing public awareness of the benefits of modern medicine and (b) an improvement and control of the quality of herbal remedies to raise the standard of malaria treatment in countries such as Ghana.

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“…Herbal antimalarial products, which are the most popular herbal products on the Ghanaian market, are usually composed of a mixture of a variety of herbal extracts [ 16 ]. Although the independent aqueous extracts of A .…”

Section: Introductionmentioning

confidence: 99%

The Effectiveness of Varying Combination Ratios of A. cordifolia and M. indica against Field and Laboratory Strains of P. falciparum In Vitro

Jibira

Cudjoe

Tei-Maya

et al. 2020

Journal of Parasitology Research

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Background. Drug resistance in malaria is a global problem, with reports of Plasmodium parasites resistant to the current first-line antimalarial drug, artemisinin, expanding from Southeast Asia to Africa. There is therefore an urgent need to identify new drug candidates that will be effective against the existing malaria parasites. Drug combination therapy presents a myriad of advantages over monotherapy including delayed onset of resistance, potentiation, and synergism. This present study explored the effectiveness of combinations of aqueous extracts of Alchornea cordifolia (A. cordifolia) and Mangifera indica (M. indica) at clearing both laboratory and field isolates of P. falciparum. Methods. Synchronized ring stage cultures of field (FA08) and laboratory strains (NF54 and CamWT_C580Y) of P. falciparum were subjected to combinations of different concentrations and ratios of aqueous extracts of A. cordifolia and M. indica. The growth inhibition of the individual plant extracts and their combinatory effects were studied in vitro using SYBR Green I drug assay. Results. The A. cordifolia extract exhibited 50% inhibitory concentration (IC50) of 2.71, 7.80, and 3.56 μg/mL against the NF54, CamWT_C580Y, and FA08 parasite strains, respectively. Mangifera indica exhibited IC50 of 18.11, 20.08, and 10.23 μg/mL against the NF54, CamWT_C580Y, and FA08 parasite strains, respectively. Additive, synergistic and antagonistic interactions were observed at different combinations of A. cordifolia and M. indica extracts. Conclusion. A combination product containing A. cordifolia and M. indica has the potential to serve as an effective antimalarial as majority of the tested combinations of aqueous extracts of A. cordifolia and M. indica extracts exhibited synergistic effects in vitro against the NF54, CamWT_C580Y, and FA08 P. falciparum strains.

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In vivo efficacy of top five surveyed Ghanaian herbal anti-malarial products

Cited by 17 publications

References 14 publications

Antimalarial Drugs in Ghana: A Case Study on Personal Preferences

Antimalarial Drugs in Ghana: A Case Study on Personal Preferences

Antimalarial Drugs in Ghana: A Case Study on Personal Preferences

The Effectiveness of Varying Combination Ratios of A. cordifolia and M. indica against Field and Laboratory Strains of P. falciparum In Vitro

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