In Vivo Efficacy of an Injectable Human Acellular Dermal Matrix

Ko, Hyemi; Kim, Dong-Hyun; Shin, Chungmin; Gong, Na Young; You, Boram; Oh, Han Seul; Lee, Jinsun; Oh, Sang‐Ha

doi:10.1007/s00266-023-03353-8

Cited by 1 publication

(3 citation statements)

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“…To determine the efficiency of biointegration, the infiltration and proliferation of fibroblasts into hADMs were measured. As a measurement method, we calculated the cell penetration efficiency as the ratio of the hADM area occupied by fibroblasts to the total area of the hADM on a slide [7]. In this study, it was confirmed that the cell penetration efficiency was significantly increased in the plasma-treated group, ensuring long-term structural integrity and durability, which indicates an increased biointegration efficiency.…”

Section: Discussionmentioning

confidence: 57%

“…The manufacturing of acellular dermal matrices (ADMs) involves the removal of cellular components that could potentially induce rejection or inflammation. The resulting tissue matrix retains its structural integrity, serving as a biological scaffold conducive to tissue ingrowth, angiogenesis, and, ultimately, tissue regeneration [6,7]. After mastectomy procedures, ADMs find applications in creating tissue expander pockets (in two-stage reconstructions) or implant pockets (in direct-to-implant reconstructions) [3].…”

Section: Discussionmentioning

confidence: 99%

“…ADM characteristics differ, including the tissue type, additives (e.g., antibiotics or surfactants), and preparation methods [5]. The ongoing efforts to enhance ADM performance include the use of mechanically made micronized ADMs [7]. In this way, efforts to improve the performance of ADMs have continued.…”

Section: Introductionmentioning

confidence: 99%

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Improvement in Biocompatibility and Biointegration of Human Acellular Dermal Matrix through Vacuum Plasma Surface Treatment

Yang,

Lee,

Shin

et al. 2024

Bioengineering

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Efforts are ongoing to enhance the functionality of human acellular dermal matrices (hADMs), which are extensively utilized in reconstructive surgeries. Among these efforts, plasma treatments, particularly vacuum plasma treatments, have recently emerged in the medical field. This study aims to investigate the efficacy of a vacuum plasma treatment in enhancing the biocompatibility and biointegration of hADMs. Utilizing a plasma activator (ACTILINK reborn, Plasmapp Co., Ltd., Daejeon, Republic of Korea), hADMs were treated and evaluated through in vitro and in vivo analyses. Hydrophilicity changes were gauged by the blood absorption times, while SEM imaging was used to analyze physical surface deformation. Protein adsorption was measured with fluorescently labeled bovine serum albumin and fibronectin. For the in vivo study, mice were implanted with plasma-treated and untreated hADMs, and the post-implantation effects were analyzed through histological and immunofluorescence microscopy. The plasma-treated hADMs demonstrated a significantly enhanced hydrophilicity compared to the untreated samples. SEM imaging confirmed the maintenance of the microroughness after the treatment. The treated hADMs showed a significant reduction in fibronectin adsorption, a critical factor for cellular adhesion. In vivo, the plasma-treated hADMs exhibited reduced capsule formation and enhanced fibroblast infiltration, indicating improved biocompatibility and integration. These findings highlight the potential of a plasma treatment to enhance the performance of hADMs in clinical settings, offering a promising avenue for improving reconstructive surgery outcomes.

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Section: Discussionmentioning

confidence: 57%