In vivo effects of neomycin sulfate on non-specific immunity, oxidative damage and replication of cyprinid herpesvirus 2 in crucian carp (Carassius auratus gibelio)

Sun, Peng; Yu, Fei; Lu, Jian-Fei; Zhang, Minli; Wang, Hao; Xu, Dan; Lu, Liqun

doi:10.1016/j.aaf.2018.09.003

Cited by 13 publications

(7 citation statements)

References 26 publications

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“…found that hybrid tilapia fed florfenicol showed a higher quantity of the complement components C3 and C4 ( 60 ). Moreover, an acute oral administration of neomycin to crucian carp ( Carassius auratus gibelio ) revealed increases in the complement C3 content in the blood ( 61 ). Interestingly, although we did not observe an inhibition of the complement and coagulation components in the kidney of fish exposed to SMX-CLA in the absence of infection, those animals showed a reduced ability to increase the transcription of the complement components after the SVCV challenge.…”

Section: Discussionmentioning

confidence: 99%

An environmentally relevant concentration of antibiotics impairs the immune system of zebrafish (Danio rerio) and increases susceptibility to virus infection

Pereiro

Rey-Campos²,

Figueras³

et al. 2023

Front. Immunol.

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In this work, we analysed the transcriptome and metatranscriptome profiles of zebrafish exposed to an environmental concentration of the two antibiotics most frequently detected in European inland surface water, sulfamethoxazole (SMX) and clarithromycin (CLA). We found that those animals exposed to antibiotics (SMX+CLA) for two weeks showed a higher bacterial load in both the intestine and kidney; however, significant differences in the relative abundance of certain bacterial classes were found only in the intestine, which also showed an altered fungal profile. RNA-Seq analysis revealed that the complement/coagulation system is likely the most altered immune mechanism, although not the only one, in the intestine of fish exposed to antibiotics, with numerous genes inhibited compared to the control fish. On the other hand, the effect of SMX+CLA in the kidney was more modest, and an evident impact on the immune system was not observed. However, infection of both groups with spring viremia of carp virus (SVCV) revealed a completely different response to the virus and an inability of the fish exposed to antibiotics to respond with an increase in the transcription of complement-related genes, a process that was highly activated in the kidney of the untreated zebrafish after SVCV challenge. Together with the higher susceptibility to SVCV of zebrafish treated with SMX+CLA, this suggests that complement system impairment is one of the most important mechanisms involved in antibiotic-mediated immunosuppression. We also observed that zebrafish larvae exposed to SMX+CLA for 7 days showed a lower number of macrophages and neutrophils.

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Section: Discussionmentioning

confidence: 99%

An environmentally relevant concentration of antibiotics impairs the immune system of zebrafish (Danio rerio) and increases susceptibility to virus infection

Pereiro

Rey-Campos²,

Figueras³

et al. 2023

Front. Immunol.

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“… 159 Finally, the antiviral activity of neomycin sulfate was also proved in bony fish (crucian carp) against cyprinid herpes virus-2 as the drug was able to inhibit the viral replication and protect it from the infection. 160 …”

Section: Drugs Acting On Other Dna Virusesmentioning

confidence: 99%

Antiviral Activity of Approved Antibacterial, Antifungal, Antiprotozoal and Anthelmintic Drugs: Chances for Drug Repurposing for Antiviral Drug Discovery

Abdulaziz¹,

Elhadi²,

ABDALLAH³

et al. 2022

JEP

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Drug repurposing process aims to identify new uses for the existing drugs to overcome traditional de novo drug discovery and development challenges. At the same time, as viral infections became a serious threat to humans and the viral organism itself has a high ability to mutate genetically, and due to serious adverse effects that result from antiviral drugs, there are crucial needs for the discovery of new antiviral drugs, and to identify new antiviral effects for the exciting approved drugs towards different types of viral infections depending on the observed antiviral activity in preclinical studies or clinical findings is one of the approaches to counter the viral infections problems. This narrative review article summarized mainly the published preclinical studies that evaluated the antiviral activity of drugs that are approved and used mainly as antibacterial, antifungal, antiprotozoal, and anthelmintic drugs, and the preclinical studies included the in silico, in vitro, and in vivo findings, additionally some clinical observations were also included while trying to relate them to the preclinical findings. Finally, the structure used for writing about the antiviral activity of the drugs was according to the families of the viruses used in the studies to form a better image for the target of antiviral activity of different drugs in the different kinds of viruses and to relate between the antiviral activity of the drugs against different strains of viruses within the same viral family.

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“…28 In clinical applications, employing antibiotics or incorporating bioactive molecules into the dressing is the most common and effective practice in tackling infection. Neomycin (NEO), an aminoglycoside antibiotic with high water-solubility and strong antibacterial activity against both Gram-positive and Gram-negative bacteria, 29,30 has been used to treat the bacterial wound infections. 31 Controlled release of NEO for treating the wound through its physical loading in various carriers has been studied by others.…”

Section: Introductionmentioning

confidence: 99%

“…In clinical applications, employing antibiotics or incorporating bioactive molecules into the dressing is the most common and effective practice in tackling infection. Neomycin (NEO), an aminoglycoside antibiotic with high water-solubility and strong antibacterial activity against both Gram-positive and Gram-negative bacteria, , has been used to treat the bacterial wound infections . Controlled release of NEO for treating the wound through its physical loading in various carriers has been studied by others. − However, it has been seldom reported that the drug containing multiple amino groups engages in acting as a cross-linking agent, resulting in synergetic-enhanced mechanical performance and tunable drug release in a stimuli-responsive manner.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial/Biocompatible Hydrogels Dual-Reinforced by Cellulose as Ultrastretchable and Rapid Self-Healing Wound Dressing

et al. 2021

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Hydrogels as a wound dressing, integrated with ultrastretchability, rapid self-healing, and excellent antimicrobial activity, are in high demand, particularly for joint skin wound healing. Herein, a multifunctional and ductile composite hydrogel was developed using poly(vinyl alcohol) (PVA)-borax gel as a matrix that was synergized or dual-reinforced with dopamine-grafted oxidized carboxymethyl cellulose (OCMC-DA) and cellulose nanofibers (CNF). Moreover, neomycin (NEO), an aminoglycoside antibiotic with multifunctional groups, was incorporated into the hydrogel network as both an antibacterial agent and a cross-linker. The dynamic reversible borate ester linkages and hydrogen bonds between OCMC-DA, PVA, and CNF, along with dynamic cross-linking imine linkages between NEO and OCMC-DA, endowed the hydrogel with excellent self-healing ability and stretchability (3300%). The as-reinforced networks enhanced the mechanical properties of hydrogels significantly. More remarkably, the composite hydrogel with improved biodegradability and biocompatibility is pH-responsive and effective against a broad spectrum of bacteria, which is attributed to the controllable release of NEO for steady availability of the antibiotic on the wound location. Overall, the antimicrobial hydrogel with rapid self-healing and reliable mechanical properties holds significant promise as dressing material for wound healing.

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In vivo effects of neomycin sulfate on non-specific immunity, oxidative damage and replication of cyprinid herpesvirus 2 in crucian carp (Carassius auratus gibelio)

Cited by 13 publications

References 26 publications

An environmentally relevant concentration of antibiotics impairs the immune system of zebrafish (Danio rerio) and increases susceptibility to virus infection

An environmentally relevant concentration of antibiotics impairs the immune system of zebrafish (Danio rerio) and increases susceptibility to virus infection

Antiviral Activity of Approved Antibacterial, Antifungal, Antiprotozoal and Anthelmintic Drugs: Chances for Drug Repurposing for Antiviral Drug Discovery

Antimicrobial/Biocompatible Hydrogels Dual-Reinforced by Cellulose as Ultrastretchable and Rapid Self-Healing Wound Dressing

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