In vivo effects of leptin on lymphocyte subpopulations in mice

Üner, Aykut Göktürk; Sulu, Nesrin

doi:10.1016/j.imbio.2011.12.013

Cited by 3 publications

(2 citation statements)

References 60 publications

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“…The results of this study show that the adipokine supplementation did not modify the body weight gain pattern, the BMI or the Lee index, suggesting that the administration of leptin and adiponectin did not modify the body mass of the animals. These results are in accordance with other studies performed with rats that were orally administered with leptin during the suckling period (22,32) , and also in old male mice receiving subcutaneous doses of leptin (33) . Taking into account the role of leptin in satiety and suppression of appetite described in adults (34,35) , a weight loss would have been expected.…”

Section: Discussionsupporting

confidence: 93%

Leptin and adiponectin supplementation modifies mesenteric lymph node lymphocyte composition and functionality in suckling rats

et al. 2018

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At birth, when immune responses are insufficient, there begins the development of the defence capability against pathogens. Leptin and adiponectin, adipokines that are present in breast milk, have been shown to play a role in the regulation of immune responses. We report here, for the first time, the influence of in vivo adipokine supplementation on the intestinal immune system in early life. Suckling Wistar rats were daily supplemented with leptin (0·7 μg/kg per d, n 36) or adiponectin (35 μg/kg per d, n 36) during the suckling period. The lymphocyte composition, proliferation and cytokine secretion from mesenteric lymph node lymphocytes (on days 14 and 21), as well as intestinal IgA and IgM concentration (day 21), were evaluated. At day 14, leptin supplementation significantly increased the TCRαβ + cell proportion in mesenteric lymph nodes, in particular owing to an increase in the TCRαβ + CD8+ cell population. Moreover, the leptin or adiponectin supplementation promoted the early development CD8+ cells, with adiponectin being the only adipokine capable of enhancing the lymphoproliferative ability at the end of the suckling period. Although leptin decreased intestinal IgA concentration, it had a trophic effect on the intestine in early life. Supplementation of both adipokines modulated the cytokine profile during (day 14) and at the end (day 21) of the suckling period. These results suggest that leptin and adiponectin during suckling play a role in the development of mucosal immunity in early life.

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Section: Discussionsupporting

confidence: 93%

Leptin and adiponectin supplementation modifies mesenteric lymph node lymphocyte composition and functionality in suckling rats

et al. 2018

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“…It has been shown that absence of leptin causes immunosuppression in mice and humans, which is reversed after leptin administration (UNER; SULU, 2012). Among other leptin physiological actions, its effects on platelet aggregation, angiogenesis and vascular smooth muscle cell proliferation stand out (BLÜHER, 2012).…”

Section: Introductionmentioning

confidence: 99%

Effects of leptin and adinopectin on cardiovascular, respiratory and haematological systems of healthy dogs

Queiróz

Macêdo

Chaves

et al. 2017

AVB

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Article historyAdipocytokines are substances produced by adipocytes responsible for the regulation of several physiological processes. Among those substances, leptin and adiponectin have been intensively investigated because of their possible effects on metabolism, reproduction, hematopoiesis and cardiovascular system. The current study aimed to assess the effects of adipocytokines, leptin and adiponectin on cardiac and respiratory functions, as well as on the hematological parameters of healthy female dogs of different breeds. Parameters of rectal temperature, diastolic blood pressure, systolic blood pressure, mean arterial pressure, pulse, heart rate and respiratory rate were evaluated in fifty two healthy female dogs. Blood samples were collected for complete blood count and plasma leptin and adiponectin measurement via ELISA technique. There was no difference in circulating levels of adipocytokines among the different breeds (p ≤ 0,05). Negative correlation between leptin and mean corpuscular hemoglobin concentration was found, while it was positive regarding systolic blood pressure, heart rate and breathing. Adiponectin was positively correlated with red blood cells and platelets and negatively with heart rate, respiratory rate, diastolic blood pressure and pulse. Adipocytokines, leptin and adiponectin, exert regulatory effects on cardiorespiratory function and hematopoiesis in healthy female dogs.

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Ghrelin–leptin network influences serum chitinase 3-like protein 1 (YKL-40) levels in obese prepubertal children

Kyrgios

Galli-Tsinopoulou

Stylianou

2013

Regulatory Peptides

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In vivo effects of leptin on lymphocyte subpopulations in mice

Cited by 3 publications

References 60 publications

Leptin and adiponectin supplementation modifies mesenteric lymph node lymphocyte composition and functionality in suckling rats

Leptin and adiponectin supplementation modifies mesenteric lymph node lymphocyte composition and functionality in suckling rats

Effects of leptin and adinopectin on cardiovascular, respiratory and haematological systems of healthy dogs

Ghrelin–leptin network influences serum chitinase 3-like protein 1 (YKL-40) levels in obese prepubertal children

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