In vivo effects of <i>Candida albicans</i> products on rat oral epithelium

Reed, M; Scragg, M. A.; Williams, Dennis; Soames, J.V.

doi:10.1111/j.1600-0714.1990.tb00854.x

Cited by 24 publications

(10 citation statements)

References 27 publications

(27 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…10,11 Yeasts and, most importantly, C. albicans have been associated with oral and skin diseases as well as with epithelial hyperplasia. 12 Moreover, it has been emphasized that even colonization or subclinical infection with Candida spp. may be associated with postlaser resurfacing pruritus.…”

Section: Discussionmentioning

confidence: 99%

In Vivo Effect of Carbon Dioxide Laser-Skin Resurfacing and Mechanical Abrasion on the Skin's Microbial Flora in an Animal Model

Manolis

Tsakris

Kaklamanos

et al. 2006

Dermatologic Surgery

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

In Vivo Effect of Carbon Dioxide Laser-Skin Resurfacing and Mechanical Abrasion on the Skin's Microbial Flora in an Animal Model

Manolis

Tsakris

Kaklamanos

et al. 2006

Dermatologic Surgery

View full text Add to dashboard Cite

show abstract

“…C. albicans hyphae have been shown to release soluble products that can increase epithelial cell metabolic functions (32), and therefore could use the same strategy to stimulate cytokine secretion by this cell type, in the absence of cell–cell contact. Several Candida exotoxins, secretion of which coincides with the transition of yeast to hyphae, stimulate macrophages to produce tumor necrosis factor α in vitro (28).…”

Section: Discussionmentioning

confidence: 99%

Granulocyte‐macrophage colony‐stimulating factor responses of oral epithelial cells to Candida albicans

Dongari-Bagtzoglou

Kashleva

2003

Oral Microbiology and Immunology

View full text Add to dashboard Cite

Candida albicans is the principal fungal species responsible for oropharyngeal candidiasis, the most frequent opportunistic infection associated with immune deficiencies. Cytokines, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), are important in the generation of effective immunity to C. albicans. The purposes of this investigation were to determine whether C. albicans triggers secretion of GM-CSF by oral epithelial cells in vitro and to investigate mechanisms of host cell-fungal interactions that trigger such responses. Oral epithelial cell lines as well as primary oral mucosal epithelial cells were challenged with stationary phase viable C. albicans, added to human cell cultures at varying yeast:oral cell ratios. Yeast were allowed to germinate for up to 48 h and supernatants were analyzed for GM-CSF by ELISA. Fixed organisms, germination-deficient mutants and separation of yeast from epithelial cells using cell culture inserts were used to assess the effects of viability, germination and physical contact, respectively, on the GM-CSF responses of these cells. Two out of three cell lines and three out of six primary cultures responded to C. albicans with an increase in GM-CSF secretion. GM-CSF responses were contact-dependent, strain-dependent, required yeast viability and were optimal when the yeast germinated into hyphae.

show abstract

“…C. albicans has been shown to release soluble products that can increase epithelial cell metabolic functions ( 38), and therefore could use the same strategy to stimulate cytokine secretion in the absence of cell‐cell contact. To test this hypothesis, physical separation between fungal colonies and fibroblasts was used during coculture.…”

Section: Discussionmentioning

confidence: 99%

Candida albicans triggers interleukin‐6 and interleukin‐8 responses by oral fibroblasts in vitro

Dongari-Bagtzoglou¹,

Wen²,

Lamster³

1999

Oral Microbiology and Immunology

View full text Add to dashboard Cite

Oral candidiasis is the most frequent opportunistic infection associated with an immunocompromised host. Production of proinflammatory cytokines, such as interleukin-6 (IL-6) and IL-8, by host cells in response to Candida albicans can be expected to have a major impact in the activation of immune effector cells against the invading microorganism. Using a human cell--C. albicans coculture model system, we determined that this microorganism can trigger secretion of these potent chemoattractant and proinflammatory cytokines by oral mucosal fibroblasts. This response varied depending on the infecting strain and required fungal viability, germination of yeast into hyphae and mannose-mediated direct contact between the host cell and Candida. The secretion of proinflammatory cytokines by oral mucosal fibroblasts in response to C. albicans suggests that these cells have the potential to enhance the host defense against this organism in vivo. This may have important implications in controlling fungal overgrowth in the oral cavity.

show abstract

In vivo effects of Candida albicans products on rat oral epithelium

Cited by 24 publications

References 27 publications

In Vivo Effect of Carbon Dioxide Laser-Skin Resurfacing and Mechanical Abrasion on the Skin's Microbial Flora in an Animal Model

In Vivo Effect of Carbon Dioxide Laser-Skin Resurfacing and Mechanical Abrasion on the Skin's Microbial Flora in an Animal Model

Granulocyte‐macrophage colony‐stimulating factor responses of oral epithelial cells to Candida albicans

Candida albicans triggers interleukin‐6 and interleukin‐8 responses by oral fibroblasts in vitro

Contact Info

Product

Resources

About